Clinical presentation of invasive disease caused by Neisseria meningitidis serogroup Y in Sweden, 1995 to 2012
Open accessAbstract
Over the period 1995-2012, the incidence of invasive meningococcal disease (IMD) caused by Neisseria meningitidis serogroup Y (NmY) increased significantly in Sweden. This is mainly due to the emergence of a predominant cluster named strain type YI subtype 1, belonging to the ST-23 clonal complex (cc). The aim of this study was to examine the clinical picture of patients with invasive disease caused by NmY and to analyse whether the predominant cluster exhibits certain clinical characteristics that might explain the increased incidence. In this retrospective observational study, the medical records available from patients with IMD caused by Nm serogroup Y in Sweden between 1995 and 2012 were systematically reviewed. Patient characteristics, in-hospital findings and outcome were studied and differences between the dominating cluster and other isolates were analysed. Medical records from 175 of 191 patients were retrieved. The median age was 62 years. The all-cause mortality within 30 days of admission was 9% (15/175) in the whole material; 4% (2/54) in the cohort with strain type YI subtype 1 and 11% (12/121) among patients with other isolates. Thirty-three per cent of the patients were diagnosed with meningitis, 19% with pneumonia, 10% with arthritis and 35% were found to have bacteraemia but no apparent organ manifestation. This survey included cases with an aggressive clinical course as well as cases with a relatively mild clinical presentation. There was a trend towards lower mortality and less-severe disease in the cohort with strain type YI subtype 1 compared with the group with other isolates.
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The incidence of invasive MenY disease has been increasing in Sweden, Canada and the US.
“The incidence of invasive MenY disease has been increasing in Sweden, Canada and the US.19”
From Community-acquired acute bacterial meningitis in adults: a clinical update (2019) · cites this paper as [19]
The Abstract states that invasive MenY incidence increased significantly in Sweden from 1995 to 2012. The Introduction reports an increased proportion of MenY cases in the USA, but does not establish an increased incidence there; it does not mention Canada in its account of countries with increases. (LLM, conf=0.88)
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Community-acquired acute bacterial meningitis in adults: a clinical update
Ellis, J., Luintel, A., Chandna, A., & Heyderman, R. S. (2019) · British Medical Bulletin · doi:10.1093/bmb/ldz023 · Cited by 12 · see citing works
- Authors
- SÄLL, O., STENMARK, B., GLIMÅKER, M., JACOBSSON, S., MÖLLING, P., OLCÉN, P., & FREDLUND, H.
- Affiliations
- Örebro University (SE)
- Karolinska University Hospital (SE)
- Corresponding author
- SÄLL, O.
- Venue
- Epidemiology and Infection
- Publisher
- Cambridge University Press (CUP)
- Published
- 2017-05-08
- Volume
- 145
- Issue
- 10
- Pages
- 2137-2143
- ISSN
- 0950-2688 (ISSN-L)
- 1469-4409
- PMC
- PMC5968308
- OpenAlex
- W2613151783
- Cited by
- 29
- References
- 21
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 7 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 5 · 2019: 3 · 2018: 3
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Epidemiology and Infection (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Region Örebro län
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Bacterial Identification and Susceptibility Testing
- Keywords
- Neisseria meningitidis serogroup Y, invasive meningococcal disease, clinical features, disease incidence, mortality, meningitis, bacteremia, pneumonia, arthritis, Sweden
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Meningitis, Meningococcal, Meningococcal Infections, Middle Aged, Retrospective Studies, Sweden, Incidence, Neisseria meningitidis, Serogroup Y, Young Adult
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