Visual behavior of adult goldfish with regenerating retina
Abstract
To determine whether regenerating neural pathways can support visual behavior, adult goldfish (Carassius auratus) were injected intraocularly with ouabain and tested for the presence of reflexive visual behaviors (dorsal light reflex and optokinetic nystagmus) and the ability to respond to visual stimuli in a classical conditioning paradigm. All visual behaviors were absent or greatly diminished until 8 to 10 weeks, when retinal layering had returned. At 10 weeks post-ouabain, reflexive behaviors to supra-threshold stimuli were near normal; however the ability to detect supra-threshold stimuli in the conditioning paradigm did not recover until 13 weeks. Absolute dark-adapted threshold and light-adapted spectral sensitivity measured at 13 to 17 weeks were abnormal: Dark-adapted threshold was elevated by 1.5 log units and light-adapted spectral sensitivity was markedly narrower than normal. No responses to 50% contrast sinusoidal gratings could be obtained through ouabain-treated eyes using the classical conditioning technique, even though responses through the untreated eye remained. Results demonstrate that: (a) visually mediated behaviors return in goldfish with ouabain-treated retinas; (b) the time course of recovery of reflexive responses in luminance and spatial domains parallels return of ERG function and of tectal activity; and (c) visual function that is mediated by regenerating retina appears not to be as sensitive as vision via normally developed retinal pathways.
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Teleost fish such as zebrafish can regenerate a damaged retina and restore sight.
“In contrast, teleost fish, like zebrafish exhibit a remarkable regenerative ability that can restore sight to a damaged retina (Lindsey and Powers, 2007; Mensinger and Powers, 1999; Sherpa et al., 2008).”
From Retinal injury, growth factors, and cytokines converge on β-catenin and pStat3 signaling to stimulate retina regeneration (2014) · cites this paper as Lindsey and Powers, 2007
Cites
Genesis of rods in teleost fish retina
Johns, P. R., & Fernald, R. D. (1981) · Nature · doi:10.1038/293141a0 · Cited by 274 · see citing works
Stem cells in the teleost retina: persistent neurogenesis and injury-induced regeneration
Otteson, D. C., & Hitchcock, P. F. (2003) · Vision Research · doi:10.1016/s0042-6989(02)00400-5 · Cited by 231 · see citing works
Putative Stem Cells and the Lineage of Rod Photoreceptors in the Mature Retina of the Goldfish
Otteson, D. C., D’Costa, A. R., & Hitchcock, P. F. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0163 · Cited by 195 · see citing works
Formation of photoreceptors in larval and adult goldfish
Johns, P. (1982) · Journal of Neuroscience · doi:10.1523/jneurosci.02-02-00178.1982 · Cited by 191 · see citing works
Responses of Müller glia to retinal injury in adult zebrafish
Yurco, P., & Cameron, D. A. (2004) · Vision Research · doi:10.1016/j.visres.2004.10.022 · Cited by 177 · see citing works
Persistent and injury-induced neurogenesis in the vertebrate retina
Hitchcock, P. F., Ochocinska, M. J., Sieh, A., & Otteson, D. C. (2004) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2004.01.001 · Cited by 174 · see citing works
Regeneration of goldfish retina: Rod precursors are a likely source of regenerated cells
Raymond, P. A., Reifler, M. J., & Rivlin, P. K. (1988) · Journal of Neurobiology · doi:10.1002/neu.480190504 · Cited by 170 · see citing works
Germinal cells in the goldfish retina that produce rod photoreceptors
Raymond, P. A., & Rivlin, P. K. (1987) · Developmental Biology · doi:10.1016/0012-1606(87)90338-1 · Cited by 159 · see citing works
Birth and fate of proliferative cells in the inner nuclear layer of the mature fish retina
Julian, D. A., Ennis, K., & Korenbrot, J. I. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980511)394:3 · Cited by 154 · see citing works
Wu, D. M., Schneiderman, T. E., Burgett, J., Gokhale, P. J., Barthel, L., & Raymond, P. A. (2001) · PubMed · Cited by 141 · see citing works
Local regeneration in the retina of the goldfish
Hitchcock, P. F., Myhr, K. L., Easter, S. S., et al. (1992) · Journal of Neurobiology · doi:10.1002/neu.480230209 · Cited by 134 · see citing works
The role of the optic tectum in various visually mediated behaviors of goldfish
Springer, A. D., Easter, S. S., & Agranoff, B. W. (1977) · Brain Research · doi:10.1016/0006-8993(77)90166-4 · Cited by 120 · see citing works
Selective regeneration of photoreceptors in goldfish retina
Braisted, J. E., Essman, T. F., & Raymond, P. A. (1994) · Development · doi:10.1242/dev.120.9.2409 · Cited by 119 · see citing works
Regeneration of the goldfish retina after exposure to different doses of ouabain
Maier, W. A., III, & Wolburg, H. (1979) · Cell and Tissue Research · doi:10.1007/bf00239223 · Cited by 110 · see citing works
Histogenesis of the goldfish retina
Sharma, S. C., & Ungar, F. (1980) · The Journal of Comparative Neurology · doi:10.1002/cne.901910305 · Cited by 99 · see citing works
How the Neural Retina Regenerates
Raymond, P. A., & Hitchcock, P. F. (2000) · Results and problems in cell differentiation · doi:10.1007/978-3-540-46826-4_11 · Cited by 83 · see citing works
Raymond, P., Easter, S., Burnham, J., et al. (1983) · Journal of Neuroscience · doi:10.1523/jneurosci.03-05-01092.1983 · Cited by 68 · see citing works
Regeneration of dopaminergic neurons in goldfish retina
Braisted, J. E., & Raymond, P. A. (1992) · Development · doi:10.1242/dev.114.4.913 · Cited by 65 · see citing works
Visual function in regenerating teleost retina following cytotoxic lesioning
MENSINGER, A. F., & POWERS, M. K. (1999) · Visual Neuroscience · doi:10.1017/s0952523899162059 · Cited by 63 · see citing works
Self-citationMader, M. M., & Cameron, D. A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3343-04.2004 · Cited by 60 · see citing works
Absolute visual sensitivity of the goldfish
Powers, M. K., & Easter, S. S. (1978) · Vision Research · doi:10.1016/0042-6989(78)90097-4 · Cited by 53 · see citing works
Self-citationCircadian rhythm in goldfish visual sensitivity.
Bassi, C. J., & Powers, M. K. (1987) · PubMed · Cited by 52 · see citing works
Self-citationBilotta, J., & Powers, M. K. (1991) · Vision Research · doi:10.1016/0042-6989(91)90108-h · Cited by 37 · see citing works
Self-citationLight-adapted spectral sensitivity of the goldfish: A reflex measure
Powers, M. K. (1978) · Vision Research · doi:10.1016/0042-6989(78)90096-2 · Cited by 36 · see citing works
Self-citationKurz-Isler, G., & Wolburg, H. (1982) · Cell and Tissue Research · doi:10.1007/bf00216226 · Cited by 33 · see citing works
Lighting conditions and retinal development in goldfish: absolute visual sensitivity.
Powers, M. K., Bassi, C. J., & Raymond, P. A. (1988) · PubMed · Cited by 20 · see citing works
Self-citationLight transmittance by goldfish eyes of different sizes
Bassi, C. J., Williams, R. C., & Powers, M. K. (1984) · Vision Research · doi:10.1016/0042-6989(84)90197-4 · Cited by 18 · see citing works
Self-citationKästner, R., & Wolburg, H. (1982) · Zeitschrift für Naturforschung C · doi:10.1515/znc-1982-11-1229 · Cited by 18 · see citing works
Effects of mean luminance on goldfish temporal contrast sensitivity
Bilotta, J., Lynd, F. M., & Powers, M. K. (1998) · Vision Research · doi:10.1016/s0042-6989(97)00162-4 · Cited by 16 · see citing works
Self-citationStuermer, C. A. O., Niepenberg, A., & Wolburg, H. (1985) · Neuroscience Letters · doi:10.1016/0304-3940(85)90076-x · Cited by 14 · see citing works
APB Selectively Reduces Visual Responses in Goldfish to High Spatiotemporal Frequencies
DeMarco, P. J., Nussdorf, J. D., Brockman, D. A., et al. (1989) · Visual Neuroscience · doi:10.1017/s0952523800004272 · Cited by 13 · see citing works
Morphology and visual pigment content of photoreceptors from injured goldfish retina
CAMERON, D. A., & Powers, M. K. (2000) · Visual Neuroscience · doi:10.1017/s0952523800174115 · Cited by 11 · see citing works
Self-citationMetabolic activity in optic tectum during regeneration of retina in adult goldfish
Melzer, P., & Powers, M. K. (2001) · Visual Neuroscience · doi:10.1017/s0952523801184099 · Cited by 8 · see citing works
Self-citationWeak stimulus generalization using sinusoidal gratings: A cautionary note in animal psychophysics
Bilotta, J., & Powers, M. K. (1992) · Behavior Research Methods, Instruments, & Computers · doi:10.3758/bf03203595 · Cited by 8 · see citing works
Self-citationHaamedi, S. N., Karten, H. J., & Djamgoz, M. B. A. (2001) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20010319)431:4 · Cited by 8 · see citing works
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Wan, J., Zhao, X.-F., Vojtek, A., & Goldman, D. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.08.048 · Cited by 143 · see citing works
“In contrast, teleost fish, like zebrafish exhibit a remarkable regenerative ability that can restore sight to a damaged retina (Lindsey and Powers, 2007; Mensinger and Powers, 1999; Sherpa et al., 2008).”
Background
- Authors
- LINDSEY, A. E., & POWERS, M. K.
- Affiliations
- Vanderbilt University (US)
- ORCID
- POWERS, MAUREEN K.
- Venue
- Visual Neuroscience
- Publisher
- Maximum Academic Press
- Published
- 2007-05
- Volume
- 24
- Issue
- 3
- Pages
- 247-255
- ISSN
- 0952-5238 (ISSN-L)
- 1469-8714
- OpenAlex
- W2113084310
- Cited by
- 42
- References
- 35
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 2 · 2015: 3 · 2014: 3 · 2013: 1 · 2012: 1
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Visual Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ey008256-05)
- National Eye Institute (R01 EY08256, P30-EY08126, P30EY008126)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- retinal regeneration, goldfish, ouabain, optokinetic nystagmus, classical conditioning, spectral sensitivity, ERG
- MeSH terms
- Adaptation, Ocular, Animals, Behavior, Animal, Dose-Response Relationship, Drug, Goldfish, Lecithin Cholesterol Acyltransferase Deficiency, Nerve Regeneration, Neurons, Ouabain, Reflex, Retina, Vision, Ocular, Contrast Sensitivity, Nystagmus, Optokinetic
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