Cited by 118Child Abuse and TraumaEpigenetics and DNA MethylationStress Responses and Cortisol

The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.

Childhood maltreatment and methylation of FK506 binding protein 5 gene (FKBP5)

Open access

Tyrka, Audrey R., Ridout, Kathryn K., Parade, Stephanie H., Paquette, Alison, Marsit, Carmen J., Seifer, Ronald·2015·Development and Psychopathology

DOI 10.1017/s0954579415000991PMC PMC4870720

Open this paper in CoChat — free account

Abstract

A growing body of evidence suggests that alterations of the stress response system may be a mechanism by which childhood maltreatment alters risk for psychopathology. FK506 binding protein 51 (FKBP5) binds to the glucocorticoid receptor and alters its ability to respond to stress signaling. The aim of the present study was to examine methylation of the FKBP5 gene (FKBP5), and the role of an FKBP5 genetic variant, in relation to childhood maltreatment in a sample of impoverished preschool-aged children. One hundred seventy-four families participated in this study, including 69 with child welfare documentation of moderate to severe maltreatment in the past 6 months. The children, who ranged in age from 3 to 5 years, were racially and ethnically diverse. Structured record review and interviews in the home were used to assess a history of maltreatment, other traumas, and contextual life stressors; and a composite variable assessed the number exposures to these adversities. Methylation of two sites in intron 7 of FKBP5 was measured via sodium bisulfite pyrosequencing. Maltreated children had significantly lower levels of methylation at both CpG sites (p < .05). Lifetime contextual stress exposure showed a trend for lower levels of methylation at one of the sites, and a trend for an interaction with the FKBP5 polymorphism. A composite adversity variable was associated with lower levels of methylation at one of the sites as well (p < .05). FKBP5 alters glucocorticoid receptor responsiveness, and FKBP5 gene methylation may be a mechanism of the biobehavioral effects of adverse exposures in young children.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1017/s0954579415000991

Cites

118 of 118 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Physiology and neurobiology of stress and adaptation: central role of the brain
McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 5,429 · cited 1×
“Excessive activation of the HPA axis over time or in response to extreme stress may result in downregulation of this system (Fries, Hesse, Hellhammer, & Hellhammer, 2005; Heim, Ehlert, & Hellhammer, 2000; McEwen, 2007; Pryce et al., 2005; Tyrka et al., 2008).”
Background
Stress and the brain: from adaptation to disease
de Kloet, E. R., Joëls, M., & Holsboer, F. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1683 · Cited by 4,621
The Long-Term Health Consequences of Child Physical Abuse, Emotional Abuse, and Neglect: A Systematic Review and Meta-Analysis
Norman, R. E., Byambaa, M., De, R., Butchart, A., Scott, J., & Vos, T. (2012) · PLoS Medicine · doi:10.1371/journal.pmed.1001349 · Cited by 3,387
Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood
Heim, C. (2000) · JAMA · doi:10.1001/jama.284.5.592 · Cited by 1,968
Stability and flexibility of epigenetic gene regulation in mammalian development
Reik, W. (2007) · Nature · doi:10.1038/nature05918 · Cited by 1,963 · cited 2×
“be the most stable form of epigenetic alteration (Reik, 2007).”
Background
The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders
Heim, C., Ehlert, U., & Hellhammer, D. H. (2000) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(99)00035-9 · Cited by 1,688
Childhood Maltreatment Predicts Unfavorable Course of Illness and Treatment Outcome in Depression: A Meta-Analysis
Nanni, V., Uher, R., & Danese, A. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11020335 · Cited by 1,480
Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions
Klengel, T., Mehta, D., Anacker, C., Rex-Haffner, M., Pruessner, J. C., Pariante, C. M., Pace, T. W. W., Mercer, K. B., Mayberg, H. S., Bradley, B., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3275 · Cited by 1,447
Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons
Watanabe, Y., Gould, E., & McEwen, B. S. (1992) · Brain Research · doi:10.1016/0006-8993(92)91597-8 · Cited by 1,212
A new view on hypocortisolism
Fries, E., Hesse, J., Hellhammer, J., & Hellhammer, D. H. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.04.006 · Cited by 1,204

Show all 118 references

Research works printed but not linked: 1

Barnett, 1993, Child abuse, child development, and social policy, 7

Sorted by citations

Understanding the Molecular Mechanisms Underpinning Gene by Environment Interactions in Psychiatric Disorders: The FKBP5 Model
Matosin, N., Halldorsdottir, T., & Binder, E. B. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.01.021 · Cited by 226
Epigenetic Pathways in Human Disease: The Impact of DNA Methylation on Stress-Related Pathogenesis and Current Challenges in Biomarker Development
Argentieri, M. A., Nagarajan, S., Seddighzadeh, B., Baccarelli, A., & Shields, A. E. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.03.044 · Cited by 199
A systematic review of childhood maltreatment and DNA methylation: candidate gene and epigenome-wide approaches
Parade, S. H., Huffhines, L. P., Daniels, T. E., Stroud, L. R., Nugent, N. R., & Tyrka, A. R. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01207-y · Cited by 192
Self-citation
Childhood maltreatment and DNA methylation: A systematic review
Cecil, C. A. M., Zhang, Y., & Nolte, T. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.02.019 · Cited by 186
Epigenetic programming by stress and glucocorticoids along the human lifespan
Zannas, A. S., & Chrousos, G. P. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.35 · Cited by 158
Translating basic research knowledge on the biological embedding of early-life stress into novel approaches for the developmental programming of lifelong health
Heim, C. M., Entringer, S., & Buss, C. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.12.011 · Cited by 158
DNA methylation differences at the glucocorticoid receptor gene in depression are related to functional alterations in hypothalamic-pituitary-adrenal axis activity and to early life emotional abuse
Farrell, C., Doolin, K., O’ Leary, N., Jairaj, C., Roddy, D., Tozzi, L., Morris, D., Harkin, A., Frodl, T., Nemoda, Z., et al. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.04.064 · Cited by 144
Hsp90 and FKBP51: complex regulators of psychiatric diseases
Criado‐Marrero, M., Rein, T., Binder, E. B., Porter, J. T., Koren, J., & Blair, L. J. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0532 · Cited by 152
Adverse childhood experiences, epigenetics and telomere length variation in childhood and beyond: a systematic review of the literature
Lang, J., McKie, J., Smith, H. E., McLaughlin, A. L., Gillberg, C., Shiels, P. G., & Minnis, H. (2019) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-019-01329-1 · Cited by 138
The role of epigenetics in psychological resilience
Smeeth, D., Beck, S., Karam, E. G., & Pluess, M. (2021) · The Lancet Psychiatry · doi:10.1016/s2215-0366(20)30515-0 · Cited by 108
DNA methylation at stress‐related genes is associated with exposure to early life institutionalization
Non, A. L., Hollister, B. M., Humphreys, K. L., Childebayeva, A., Esteves, K. C., Zeanah, C. H., Fox, N. A., Nelson, C. A., & Drury, S. S. (2016) · American Journal of Physical Anthropology · doi:10.1002/ajpa.23010 · Cited by 114
How Stress Gets Under the Skin: Early Life Adversity and Glucocorticoid Receptor Epigenetic Regulation
Liu, P. Z., & Nusslock, R. (2017) · Current Genomics · doi:10.2174/1389202919666171228164350 · Cited by 111
Associations among oxytocin receptor gene (OXTR) DNA methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness
Gouin, J.-P., Zhou, Q. Q., Booij, L., Boivin, M., Côté, S. M., Hébert, M., Ouellet‐Morin, I., Szyf, M., Tremblay, R. E., Turecki, G., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-07950-x · Cited by 106
Influence of FKBP5 polymorphism and DNA methylation on structural changes of the brain in major depressive disorder
Han, K., Won, E., Sim, Y., Kang, J. C., Han, C., Kim, Y., Kim, S., Joe, S.-H., Lee, M.-S., Tae, W., et al. (2017) · Scientific Reports · doi:10.1038/srep42621 · Cited by 96
Identification of dynamic glucocorticoid-induced methylation changes at the FKBP5 locus
Wiechmann, T., Röh, S., Sauer, S., Czamara, D., Arloth, J., Ködel, M., Beintner, M., Knop, L., Menke, A., Binder, E. B., et al. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0682-5 · Cited by 81
Adverse Childhood Events and Health Biomarkers: A Systematic Review
Soares, S., Rocha, V., Kelly‐Irving, M., Stringhini, S., & Fraga, S. J. D. S. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2021.649825 · Cited by 96
Methylation of the glucocorticoid receptor gene, nuclear receptor subfamily 3, group C, member 1 ( NR3C1 ), in maltreated and nonmaltreated children: Associations with behavioral undercontrol, emotional lability/negativity, and externalizing and internalizing symptoms
Cicchetti, D., & Handley, E. D. (2017) · Development and Psychopathology · doi:10.1017/s0954579417001407 · Cited by 93
Advance in Stress for Depressive Disorder
Ding, Y., & Dai, J. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9271-0_8 · Cited by 86
The effects of childhood maltreatment on epigenetic regulation of stress-response associated genes: An intergenerational approach
Ramo-Fernández, L., Boeck, C., Koenig, A. M., Schury, K., Binder, E. B., Gündel, H., Fegert, J. M., Karabatsiakis, A., & Kolassa, I.-T. (2019) · Scientific Reports · doi:10.1038/s41598-018-36689-2 · Cited by 67
Cortisol and cardiometabolic disease: a target for advancing health equity
Ortiz, R., Kluwe, B., Lazarus, S. A., Teruel, M. N., & Joseph, J. J. (2022) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2022.08.002 · Cited by 73
Early Childhood Stress and Child Age Predict Longitudinal Increases in Obesogenic Eating Among Low-Income Children
Miller, A. L., Gearhardt, A. N., Retzloff, L., Sturza, J. S., Kaciroti, N., & Lumeng, J. C. (2018) · Academic Pediatrics · doi:10.1016/j.acap.2018.01.007 · Cited by 54
Childhood maltreatment, behavioral adjustment, and molecular markers of cellular aging in preschool-aged children: A cohort study
Ridout, K. K., Parade, S. H., Kao, H., Magnan, S., Seifer, R., Porton, B., Price, L. H., & Tyrka, A. R. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.05.015 · Cited by 54
Self-citation
FKBP5 DNA methylation does not mediate the association between childhood maltreatment and depression symptom severity in the Detroit Neighborhood Health Study
Bustamante, A. C., Aiello, A. E., Guffanti, G., Galea, S., Wildman, D. E., & Uddin, M. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.09.016 · Cited by 50
The Disease-Associated Chaperone FKBP51 Impairs Cognitive Function by Accelerating AMPA Receptor Recycling
Blair, L. J., Criado‐Marrero, M., Zheng, D., Wang, X., Kamath, S. G., Nordhues, B. A., Weeber, E. J., & Dickey, C. A. (2019) · eNeuro · doi:10.1523/eneuro.0242-18.2019 · Cited by 48
Harsh Parenting Predicts Novel HPA Receptor Gene Methylation and NR3C1 Methylation Predicts Cortisol Daily Slope in Middle Childhood
Lewis, C. R., Breitenstein, R. S., Henderson-Smith, A., Sowards, H., Piras, I. S., Huentelman, M. J., Doane, L. D., & Lemery‐Chalfant, K. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-00885-4 · Cited by 45
Childhood Maltreatment and Headache Disorders
Tietjen, G. E. (2016) · Current Pain and Headache Reports · doi:10.1007/s11916-016-0554-z · Cited by 43
Environmentally Induced Epigenetic Plasticity in Development: Epigenetic Toxicity and Epigenetic Adaptation
Tian, F., & Marsit, C. J. (2018) · Current Epidemiology Reports · doi:10.1007/s40471-018-0175-7 · Cited by 41
Self-citation
Targeted bisulfite sequencing: A novel tool for the assessment of DNA methylation with high sensitivity and increased coverage
Moser, D., Müller, S., Hummel, E. M., Limberg, A., Dieckmann, L., Frach, L., Pakusch, J., Flasbeck, V., Brüne, M., Beygo, J., et al. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104784 · Cited by 45
Crack cocaine addiction, early life stress and accelerated cellular aging among women
Levandowski, M. L., Tractenberg, S. G., de Azeredo, L. A., Nardi, T. D., Rovaris, D. L., Bau, C. H. D., Rizzo, L. B., Maurya, P. K., Brietzke, E. M., Tyrka, A. R., et al. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.06.009 · Cited by 44
Self-citation
Bridging Basic and Clinical Research in Early Life Adversity, DNA Methylation, and Major Depressive Disorder
Brown, A., Fiori, L. M., & Turecki, G. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00229 · Cited by 39
Childhood Maltreatment and Longitudinal Epigenetic Aging
Chang, O. D., Meier, H. C. S., Maguire‐Jack, K., Davis-Kean, P. E., & Mitchell, C. M. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.21877 · Cited by 34
History of child maltreatment and telomere length in immune cell subsets: Associations with stress- and attachment-related hormones
Boeck, C., Krause, S., Karabatsiakis, A., Schury, K., Gündel, H., Waller, C., & Kolassa, I. (2017) · Development and Psychopathology · doi:10.1017/s0954579417001055 · Cited by 35
Adverse Childhood Experiences and Methylation of the FKBP5 Gene in Patients with Psychotic Disorders
Misiak, B., Karpiński, P., Szmida, E., Grąźlewski, T., Jabłoński, M., Cyranka, K., Rymaszewska, J., Piotrowski, P., Kotowicz, K., & Frydecka, D. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9123792 · Cited by 32
Peripheral DNA methylation of HPA axis-related genes in humans: Cross-tissue convergence, two-year stability and behavioural and neural correlates
Sante, J. D., Ismaylova, E., Nemoda, Z., Gouin, J., Yu, W.-J., Caldwell, W., Vitaro, F., Szyf, M., Tremblay, R. E., & Booij, L. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.07.019 · Cited by 33
Childhood maltreatment and DNA methylation: A systematic review
Rubens, M., Bruenig, D., Adams, J. A. M., Suresh, S. M., Sathyanarayanan, A., Haslam, D. M., Shenk, C. E., Mathews, B., & Mehta, D. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105079 · Cited by 35
The effects of early trauma and the FKBP5 gene on PTSD and the HPA axis in a clinical sample of Gulf War veterans
Young, D. A., Inslicht, S. S., Metzler, T. J., Neylan, T. C., & Ross, J. A. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.03.037 · Cited by 30
Dissecting the molecular mechanisms of gene x environment interactions: implications for diagnosis and treatment of stress-related psychiatric disorders
Binder, E. B. (2017) · European Journal of Psychotraumatology · doi:10.1080/20008198.2017.1412745 · Cited by 29
Medical morbidities and DNA methylation of NR3C1 in preterm infants
Giarraputo, J., DeLoach, J., Padbury, J. F., Uzun, A., Marsit, C. J., Hawes, K., & Lester, B. M. (2016) · Pediatric Research · doi:10.1038/pr.2016.185 · Cited by 29
Self-citation
Epigenetic Mechanisms Activated by Childhood Adversity
Krause, B. J., Artigas, R., Sciolla, A., & Hamilton, J. (2020) · Epigenomics · doi:10.2217/epi-2020-0042 · Cited by 29
360-Degree Perspectives on Obesity
Cuciureanu, M. D., Caratașu, C.-C., Gabrielian, L., Frăsinariu, O. E., Checheriță, L. E., Trandafir, L. M., Stanciu, G. D., Szilagyi, A., Pogonea, I., Bordeianu, G., et al. (2023) · Medicina · doi:10.3390/medicina59061119 · Cited by 33
Association between childhood maltreatment, psychopathology and DNA methylation of genes involved in stress regulation: Evidence from a study in Borderline Personality Disorder
Flasbeck, V., & Brüne, M. (2021) · PLoS ONE · doi:10.1371/journal.pone.0248514 · Cited by 29
Childhood Trauma and Epigenetics: State of the Science and Future
Gladish, N., Merrill, S. M., & Kobor, M. S. (2022) · Current Environmental Health Reports · doi:10.1007/s40572-022-00381-5 · Cited by 34
Sex differences in associations between early adversity, child temperament, and behavior problems
Coe, J. L., Micalizzi, L., Josefson, B., Parade, S. H., Seifer, R., & Tyrka, A. R. (2020) · International Journal of Behavioral Development · doi:10.1177/0165025420912012 · Cited by 28
Self-citation
Potential epigenetic mechanisms in psychotherapy: a pilot study on DNA methylation and mentalization change in borderline personality disorder
Quevedo, Y., Booij, L., Herrera, L., Hernández, C., & Jiménez, J. P. (2022) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2022.955005 · Cited by 28
DNA methylation in regulatory elements of the FKBP5 and NR3C1 gene in mother-child binomials with depression
Mendonça, M. S., Mangiavacchi, P. M., Mendes, A. V., Loureiro, S. R., Martín-Santos, R., Glória, L. S., Marques, W., De Marco, S. P. G., Kanashiro, M. M., Hallak, J. E. C., et al. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.03.031 · Cited by 24
Methylation of FKBP5 is associated with accelerated DNA methylation ageing and cardiometabolic risk: replication in young-adult and middle-aged Black Americans
Beach, S. R. H., Ong, M. L., Lei, M., Carter, S. E., Simons, R. L., Gibbons, F. X., & Philibert, R. A. (2021) · Epigenetics · doi:10.1080/15592294.2021.1980688 · Cited by 21
Investigating epigenetic consequences of early-life adversity: some methodological considerations
Fiori, L. M., & Turecki, G. (2016) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v7.31593 · Cited by 20
DNA methylation of FKBP5 in South African women: associations with obesity and insulin resistance
Willmer, T., Goedecke, J. H., Dias, S. C., Louw, J., & Pheiffer, C. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-00932-3 · Cited by 21
No association between FKBP5 gene methylation and acute and long-term cortisol output
Alexander, N., Kirschbaum, C., Stalder, T., Muehlhan, M., & Vogel, S. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0846-2 · Cited by 22
Cascades of Risk Linking Intimate Partner Violence and Adverse Childhood Experiences to Less Sensitive Caregiving During Infancy
Coe, J. L., Huffhines, L. P., Gonzalez, D., Seifer, R., & Parade, S. H. (2021) · Child Maltreatment · doi:10.1177/10775595211000431 · Cited by 18
Self-citation
Endophenotype 2.0: updated definitions and criteria for endophenotypes of psychiatric disorders, incorporating new technologies and findings
Liu, C., & Gershon, E. S. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-03195-1 · Cited by 24
A genome-wide methylation study reveals X chromosome and childhood trauma methylation alterations associated with borderline personality disorder
Arranz, M. J., Gallego-Fabrega, C., Martín-Blanco, A., Soler, J., Elices, M., Dominguez-Clavé, E., Salazar, J., Vega, D., Briones-Buixassa, L., & Pascual, J. C. (2021) · Translational Psychiatry · doi:10.1038/s41398-020-01139-z · Cited by 17
Stressful Newborn Memories: Pre-Conceptual, In Utero, and Postnatal Events
Papadopoulou, Z. L., Vlaikou, A., Theodoridou, D., Markopoulos, G. S., Tsoni, K., Agakidou, E., Drosou‐Agakidou, V., Turck, C. W., Filiou, M. D., & Syrrou, M. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00220 · Cited by 19
Stage 2 Registered Report: Epigenetic Intergenerational Transmission: Mothers’ Adverse Childhood Experiences and DNA Methylation
Scorza, P., Duarte, C. S., Lee, S., Wu, H., Posner, J., Baccarelli, A., & Monk, C. (2023) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2023.02.018 · Cited by 18
Evaluating the Challenges and Reproducibility of Studies Investigating DNA Methylation Signatures of Psychological Stress
Zhang, Y., & Liu, C. (2022) · Epigenomics · doi:10.2217/epi-2021-0190 · Cited by 20
Neglect and Neurodevelopment: A Narrative Review Understanding the Link Between Child Neglect and Executive Function Deficits
Herrero-Roldán, S., & Martín-Rodríguez, A. (2025) · Biomedicines · doi:10.3390/biomedicines13071565 · Cited by 16
Household Chaos Moderates Indirect Pathways Involving Domestic Violence, Parenting Practices, and Behavior Problems among Preschool Children
Coe, J. L., Parade, S. H., Seifer, R., Frank, L., & Tyrka, A. R. (2019) · Journal of Family Violence · doi:10.1007/s10896-019-00093-9 · Cited by 14
Self-citation
Understanding links between maternal perinatal posttraumatic stress symptoms and infant socioemotional and physical health
Huffhines, L. P., Coe, J. L., Busuito, A., Seifer, R., & Parade, S. H. (2022) · Infant Mental Health Journal · doi:10.1002/imhj.21985 · Cited by 15
Self-citation
Methylation Patterns of the FKBP5 Gene in Association with Childhood Maltreatment and Depressive Disorders
Großmann, N. L., Weihs, A., Kühn, A. L., Sauer, S., Röh, S., Wiechmann, T., Rex‐Haffner, M., Völzke, H., Völker, U., Binder, E. B., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031485 · Cited by 18
Association between academic pressure, NR3C1 gene methylation, and anxiety symptoms among Chinese adolescents: a nested case-control study
Hua, Y., Huang, C., Guo, Y., Du, X., Guo, L., Wang, W., Lu, C., & Guo, L. (2023) · BMC Psychiatry · doi:10.1186/s12888-023-04816-7 · Cited by 16
Effortful Control, Parent-Child Relationships, and Behavior Problems among Preschool-Aged Children Experiencing Adversity
Coe, J. L., Micalizzi, L., Huffhines, L. P., Seifer, R., Tyrka, A. R., & Parade, S. H. (2023) · Journal of Child and Family Studies · doi:10.1007/s10826-023-02741-7 · Cited by 13
Self-citation
FKBP5/FKBP51-mediated signaling pathways in neuropsychiatric diseases: Insights for biomarker development and targeted therapies
Liu, Y., Lian, J., Fu, Y., Wang, S., Liu, Y., Zhang, R., & Han, H. (2025) · Neurobiology of Stress · doi:10.1016/j.ynstr.2025.100762 · Cited by 13
The FKBP5 genotype and childhood trauma effects on FKBP5 DNA methylation in patients with psychosis, their unaffected siblings, and healthy controls
Mihaljevic, M. M., Franic, D., Soldatović, I., Lukić, I., Petrović, S. A., Mirjanić, T., Stanković, B., Zukić, B., Zeljić, K., Gašić, V., et al. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105205 · Cited by 12
Sex-dependent association of DNA methylation of HPA axis-related gene FKBP5 with obsessive-compulsive disorder
Seo, J. H., Kim, S. T., Jeon, S., Kang, J. I., & Kim, S. J. (2023) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2023.106404 · Cited by 11
The Impact of Stress Within and Across Generations: Neuroscientific and Epigenetic Considerations
Miller, C. W. T. (2021) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000300 · Cited by 13
Wired for Threat: Clinical Features of Nervous System Dysregulation in 80 Children
Elbers, J. M., Jaradeh, S. S., Yeh, A. M., & Golianu, B. J. (2018) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2018.07.007 · Cited by 11
From trauma to depression: structural, synaptic, epigenetic, and molecular pathways linking early stress to lifelong vulnerability
Takahashi, M., & Shelton, R. C. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1666599 · Cited by 12
Folgen früher Traumatisierung aus neurobiologischer Sicht
Brückl, T. M., & Binder, E. B. (2017) · Forensische Psychiatrie Psychologie Kriminologie · doi:10.1007/s11757-017-0412-9 · Cited by 11
Molecular and Behavioral Effects of Infant Maltreatment across Generations in Rhesus MonkeysPreprint
Klengel, T., Morin, E. L., Howell, B., Bramlett, S. N., Guzman, D., Meyer, J. S., Ressler, K. J., & Sánchez, M. M. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/791152 · Cited by 8
Scars of childhood socioeconomic stress: A systematic review
Wood, N. M., Trebilco, T., & Cohen‐Woods, S. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.08.001 · Cited by 7
Investigating the effects of childhood maltreatment on pro-inflammatory signaling: The influence of cortisol and DHEA on cytokine secretion ex vivo
Geiger, M. L., Boeck, C., Koenig, A. M., Schury, K., Waller, C., Kolassa, S., Karabatsiakis, A., & Kolassa, I. (2018) · Mental Health & Prevention · doi:10.1016/j.mhp.2018.04.002 · Cited by 7
Examining the biological impacts of parent–child relationship dynamics on preschool‐aged children who have experienced adversity
Coe, J. L., Daniels, T. E., Huffhines, L. P., Seifer, R., Marsit, C. J., Kao, H., Porton, B., Parade, S. H., & Tyrka, A. R. (2024) · Developmental Psychobiology · doi:10.1002/dev.22463 · Cited by 7
Self-citation
Stress and Spirituality in Relation to HPA Axis Gene Methylation Among US Black women: Results from the Black Women’s Health Study and the Study on Stress, Spirituality and Health
Shields, A. E., Zhang, Y., Argentieri, M. A., Warner, E. T., Cozier, Y. C., Liu, C., Dye, C. K., Kent, B. V., Baccarelli, A., & Palmer, J. R. (2021) · Epigenomics · doi:10.2217/epi-2021-0275 · Cited by 9
Early-Life Adversity and Suicide Risk: The Role of Epigenetics
Turecki, G. (2017) · Springer eBooks · doi:10.1007/978-3-319-47976-7_4 · Cited by 6
The rs1360780 Variant of FKBP5: Genetic Variation, Epigenetic Regulation, and Behavioral Phenotypes
Marcelo Arancibia, M., Manterola, M., Ríos, U., Moya, P. R., Morán, J., & Bustamante, M. L. (2025) · Genes · doi:10.3390/genes16030325 · Cited by 8
Molecular pathways linking chronic psychological stress to accelerated aging: mechanisms and interventions
Alhazzaa, O. A., Abahussin, H. M., Majrashi, M. A., Alotaibi, M. S., Alkhrayef, M. N., Alhamdan, Z. A., & Alawad, A. O. (2026) · Frontiers in Aging · doi:10.3389/fragi.2026.1743142 · Cited by 5
The significance of DNA methylation of the NR3C1 gene encoding the glucocorticoid receptor for developing resilience in individuals exposed to early life stress
Forum, D. M. K., Bjerregaard, C., & Thomsen, P. H. (2025) · Nordic Journal of Psychiatry · doi:10.1080/08039488.2024.2436987 · Cited by 6
Association Between Childhood Maltreatment, FKBP5 Gene Methylation, and Anxiety Symptoms Among Chinese Adolescents: A Nested Case-Control Study
Lai, W., Li, W., Du, X., Guo, Y., Wang, W., Guo, L., & Lu, C. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.761898 · Cited by 5
Environmental Influence on Epigenetics
Resendiz, M., Watkins, D. S., Öztürk, N. C., & Zhou, F. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91909-8.00036-0 · Cited by 4
Child DNA methylation in a randomised controlled trial of a video-feedback intervention to promote positive parenting and sensitive discipline (VIPP-SD)
Braithwaite, E., Cole, J., Murgatroyd, C., Wright, N., O’Farrelly, C., Barker, B., & Ramchandani, P. G. (2023) · Frontiers in Child and Adolescent Psychiatry · doi:10.3389/frcha.2023.1175299 · Cited by 4
Cross Talk opposing view: The kids will be fine – a bit of parental stress won't affect them: Rodents are not good models for assessing transgenerational influences in humans
Pang, T. Y. (2022) · The Journal of Physiology · doi:10.1113/jp282410 · Cited by 4
Epigenetics and Early Life Adversity: Current Evidence and Considerations for Epigenetic Studies in the Context of Child Maltreatment
Bouvette–Turcot, A., Meaney, M. J., & O’Donnell, K. J. (2018) · Child maltreatment solutions network · doi:10.1007/978-3-319-72589-5_7 · Cited by 4
Prenatal exposures and cell type proportions are main drivers of FKBP5 DNA methylation in maltreated and non-maltreated children
Karlbauer, V. N., Martins, J., Rex‐Haffner, M., Sauer, S., Roeh, S., Dittrich, K., Dörr, P., Klawitter, H., Entringer, S., Buß, C., et al. (2024) · Neurobiology of Stress · doi:10.1016/j.ynstr.2024.100687 · Cited by 5
Dysregulated energy homeostasis at the crossroads of cancer–depression comorbidity: A brain–body–tumor interaction perspective
Zhang, M., & Jin, W.-L. (2026) · Cancer Letters · doi:10.1016/j.canlet.2026.218351 · Cited by 3
Maternal perinatal hypertensive disorders and parenting in infancy
Huffhines, L. P., Bublitz, M. H., Coe, J. L., Seifer, R., & Parade, S. H. (2022) · Infant Behavior and Development · doi:10.1016/j.infbeh.2022.101781 · Cited by 4
Self-citation
Delving Into the Interaction Between Exercise and Diabetes on Methylation of the FKBP5 Gene
Yang, T., Tsai, J., Hsu, H., Chen, Y., Liaw, Y.-C., Hsu, S. Y., Yang, H. J., & Liaw, Y. (2025) · Journal of Diabetes Research · doi:10.1155/jdr/1162708 · Cited by 3
Die Bedeutung früher traumatischer Lebenserfahrungen
Overfeld, J., Buß, C., & Heim, C. C. (2016) · InFo Neurologie + Psychiatrie · doi:10.1007/s15005-016-1782-9 · Cited by 3
Understanding the Neurobiological Implications of Maltreatment: A Commentary on the Special Issue
Koss, K. J. (2019) · Child Maltreatment · doi:10.1177/1077559519869843 · Cited by 5
DAT1 5′-Un-Translated-Region Methylation Patterns as Bio-Markers of ADHD Psycho-Pathology: Contribution to Disease Prognosis and to Monitoring of a Successful Therapy
Carpentieri, V., Cugno, S., Lockic, K., Pascale, E., & Adriani, W. (2023) · Biomedicines · doi:10.3390/biomedicines11092546 · Cited by 2
Early childhood trauma exposure and neurocognitive and emotional processes: Associations in young children in a partial hospital program
Huffhines, L. P., Parade, S. H., Martin, S. E., Gottipaty, A., Kavanaugh, B. C., Spirito, A., & Boekamp, J. R. (2024) · Development and Psychopathology · doi:10.1017/s0954579424000956 · Cited by 3
Self-citation
Longitudinal DNA methylation in parent–infant pairs impacted by intergenerational social adversity: An RCT of the Michigan Model of Infant Mental Health Home Visiting
Petroff, R., Jester, J. M., Riggs, J. L., Alfafara, E. A., Springer, K., Kerr, N., Issa, M., Hall, A., Rosenblum, K. L., Goodrich, J. M., et al. (2024) · Brain and Behavior · doi:10.1002/brb3.70035 · Cited by 2
Peer victimization and internalizing and externalizing problems among early adolescents: The longitudinal between × within moderation role of the FKBP5 gene
Gong, X., & Zhou, J. (2025) · Development and Psychopathology · doi:10.1017/s0954579425100230 · Cited by 2
Examining the moderating role of adverse childhood experiences on the link between executive functioning and depressive/anger rumination among adolescents
Vergara‐Lopez, C., Ortiz, E. G., Grados, M., DUNSIGER, S. I., Bock, B. C., Nugent, N. R., Stroud, L. R., Armey, M. F., Tyrka, A. R., & Parade, S. H. (2025) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2025.2547737 · Cited by 2
Self-citation
Adverse Childhood Experiences: Biological Signatures of Stress
Yoo, J. Y., Ravi, K. E., Sarkar, A., Lau, C., Osborn, C., & Groër, M. (2026) · Journal of Child & Adolescent Trauma · doi:10.1007/s40653-026-00860-z · Cited by 3
Epigenetics in persons living with HIV: trauma, coping, and FKBP5 and SLC6A4 methylation
Tomlinson, C. J., Ryniker, L., Cook, H. M., Schwartz, R. M., & Non, A. L. (2025) · Epigenomics · doi:10.1080/17501911.2025.2476389 · Cited by 2
Dampened positive emotion and a PTSD diagnosis are related to suicidal thoughts and behavior in young children receiving intensive psychiatric care
Boekamp, J. R., Martin, S., Liu, R. T., Kunicki, Z. J., Gottipay, A., Lin, L. W., Paszek, C., Klein, D. N., & Spirito, A. (2025) · Psychiatry Research · doi:10.1016/j.psychres.2025.116514 · Cited by 3
Modeling Pain Without Injury: Inherited Rodent Models as Mechanistic Windows into Chronic Pain
Ferrari, L. F., & Taylor, N. E. (2025) · Function · doi:10.1093/function/zqaf043 · Cited by 3
Do children with obesity have worse table manners? Associations between child table manners, weight status and weight gain
Briones, N. F., Cesaro, R. J., Appugliese, D. P., Miller, A. L., Rosenblum, K. L., & Pesch, M. H. (2018) · Appetite · doi:10.1016/j.appet.2018.01.021 · Cited by 2
Epigenetic Modifications of Early-Life Stress and Adult Life Psychopathology
Murgatroyd, C. (2020) · Progress in inflammation research · doi:10.1007/978-3-030-39335-9_3 · Cited by 2
Prospective Intergenerational Consequences of Paternal Stress Experiences on Offspring Immune Health
Guerrin, C. G. J., Trompke, M., & Pang, T. Y. (2024) · Springer eBooks · doi:10.1007/978-3-031-59286-7_10 · Cited by 1

Authors: Tyrka, A. R., Ridout, K. K., Parade, S. H., Paquette, A., Marsit, C. J., & Seifer, R.
Affiliations: Brown University (US)
Dartmouth College (US)
Corresponding author: Tyrka, Audrey R.
ORCID: Tyrka, Audrey R.
Ridout, Kathryn K.
Parade, Stephanie H.
Paquette, Alison
Marsit, Carmen J.
Seifer, Ronald
Venue: Development and Psychopathology
Publisher: Cambridge University Press (CUP)
Published: 2015-11
Volume: 27
Issue: 4pt2
Pages: 1637-1645
ISSN: 0954-5794 (ISSN-L)
1469-2198
DOI: 10.1017/s0954579415000991
PMC: PMC4870720
OpenAlex: W2163901153
Cited by: 118
References: 118
Citations by year: 2026: 6 · 2025: 15 · 2024: 10 · 2023: 12 · 2022: 9 · 2021: 10 · 2020: 11 · 2019: 11 · 2018: 11 · 2017: 16 · 2016: 7
FWCI: 14.07
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.cambridge.org/core/terms (unspecified, 3 d)
Locations: Development and Psychopathology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (R25MH101076, R01MH083704)
Topics: Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: child abuse, FKBP5, DNA methylation, glucocorticoid receptor, epigenetics, contextual stress, adversity exposure, preschool children, child welfare, psychopathology risk, stress system
MeSH terms: Tacrolimus Binding Protein 5, Child Abuse, Child, Preschool, Female, Humans, Male, Polymorphism, Genetic, Poverty, Risk, Stress, Psychological, DNA Methylation, Tacrolimus Binding Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Childhood maltreatment and methylation of FK506 binding protein 5 gene (FKBP5)

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks