Change in FK506 binding protein 5 (FKBP5) methylation over time among preschoolers with adversity
Open accessAbstract
FK506 binding protein 5 (FKBP5) alters stress response system functioning, and childhood maltreatment is associated with methylation of the FKBP5 gene. Yet it is unknown if maltreatment contributes to change in FKBP5 methylation over time. The current study draws upon a sample of 231 preschoolers, including 123 with child welfare documentation of moderate to severe maltreatment in the past 6 months, to understand if maltreatment contributes to change in FKBP5 methylation over a 6-month period. Review of child protection records and semistructured interviews in the home were used to assess maltreatment and exposure to other contextual stressors, as well as service utilization. Methylation of FKBP5 at two CpG sites in intron 7 was measured from saliva DNA at the time of initial study enrollment, and 6 months following enrollment. Child maltreatment was associated with change in FKBP5 methylation over time, but only when children were exposed to high levels of other contextual stressors. Service utilization was associated with increases in methylation over time, but only among children with the FKPB5 rs1360780 protective CC genotype. Methylation of FKBP5 is sensitive to stress exposure and may be a mechanism linking early adversity to long-term health and developmental outcomes.
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Time since adversity can moderate the magnitude of epigenetic change, while repeated or varied sources of adversity may accumulate to produce larger epigenetic responses.
“Time since adversity can moderate the magnitude of epigenetic change,53 while repeated or varied sources of adversity may accumulate to produce larger epigenetic responses.54,55”
From The role of epigenetics in psychological resilience (2021) · cites this paper as [54]
Adverse environmental events have been shown to have cumulative effects on the epigenome and may impact the epigenome and resilience in the form of developmental cascades, impacting the response to further events.
“While informative, such events are unlikely to occur alone in naturalistic settings and have been shown to have cumulative effects on the epigenome and may impact the epigenome and resilience in the form of developmental cascades, impacting the response to further events.54,55”
From The role of epigenetics in psychological resilience (2021) · cites this paper as [54]
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- Authors
- Parade, S. H., Parent, J., Rabemananjara, K., Seifer, R., Marsit, C. J., Yang, B.-Z., Zhang, H., & Tyrka, A. R.
- Affiliations
- Brown University (US)
- Florida International University (US)
- Bradley Hospital (US)
- Emory University (US)
- Yale University (US)
- Boston University (US)
- Corresponding author
- Parade, Stephanie H.
- ORCID
- Venue
- Development and Psychopathology
- Publisher
- Cambridge University Press (CUP)
- Published
- 2017-11-22
- Volume
- 29
- Issue
- 5
- Pages
- 1627-1634
- ISSN
- 0954-5794 (ISSN-L)
- 1469-2198
- PMC
- PMC5720139
- OpenAlex
- W2768507410
- Cited by
- 76
- References
- 36
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 6 · 2021: 10 · 2020: 39 · 2019: 3 · 2018: 5 · 2017: 1
- FWCI
- 16.24
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Development and Psychopathology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01AA025080)
- National Institute of Mental Health (R01MH083704)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- FKBP5, DNA methylation, child abuse, childhood adversity, preschool children, contextual stressors, service utilization, hypothalamic-pituitary-adrenal axis, epigenetics, child welfare
- MeSH terms
- Tacrolimus Binding Protein 5, Child Abuse, Child, Preschool, Female, Genotype, Humans, Introns, Male, DNA Methylation, Tacrolimus Binding Proteins
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