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Cited by 313

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Embryoid bodies: an in vitro model of mouse embryogenesis

Desbaillets, Isabelle, Ziegler, Urs, Groscurth, Peter, Gassmann, Max·2000·Experimental Physiology

Abstract

Embryonic stem (ES) cells are pluripotent cells isolated from the inner cell mass of blastocysts. ES cells are able to differentiate into the three primitive layers (endoderm, mesoderm and ectoderm) of the organism, including the germline. To study early stages of development, as well as to investigate the impact of a gene knock-out in vitro, ES cells are differentiated into three-dimensional structures called embryoid bodies, because of their ability to mimick post-implantation embryonic tissues. This review summarises the work on ES cell differentiation into haematopoietic and vascular cells, neuronal and glial cells, myocytes, and adipocytes, using this in vitro model of early embryogenesis. We also present the potential of this method to analyse the impact of genetic alterations in vitro.

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Metadata

Authors
Desbaillets, I., Ziegler, U., Groscurth, P., & Gassmann, M.
Venue
Experimental Physiology
Publisher
Wiley
Published
2000-11
Volume
85
Issue
6
Pages
645-651
ISSN
0958-0670 (ISSN-L)
OpenAlex
W4238122660
Cited by
313
References
1
FWCI
1.58
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Embryoid bodies: an in vitro model of mouse embryogenesis. https://app.cochat.ai/papers/10.1017/s0958067000021047
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Desbaillets, I., Ziegler, U., Groscurth, P., & Gassmann, M. (2000). Embryoid bodies: an in vitro model of mouse embryogenesis. Experimental Physiology. https://doi.org/10.1017/s0958067000021047

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.