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Cited by 96Mental Health Treatment and AccessAging, Health, and DisabilityAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

One-year outcomes of minor and subsyndromal depression in older primary care patients

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Lyness, Jeffrey M., Chapman, Benjamin P., McGriff, Joanne, Drayer, Rebecca, Duberstein, Paul R.·2009·International Psychogeriatrics
DOI 10.1017/s1041610208007746PMC PMC2745243
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Abstract

BACKGROUND: Despite the high prevalence and morbidity of minor and subsyndromal depression in primary care elderly people, there are few data to identify those at highest risk of poor outcomes. The goal of this observational cohort study was to characterize the one-year outcomes of minor and subsyndromal depression, examining the predictive strength of a range of putative risks including clinical, functional and psychosocial variables. METHODS: Patients aged > or = 65 years were recruited from primary care medicine and family medicine practices. Of 750 enrollees, 484 (64.5%) completed baseline and one-year follow-up assessments of depression diagnosis (major depression vs. minor and subsyndromal depression vs. non-depressed) by the Structured Clinical Interview for DSM-IV, depressive symptom severity (Hamilton Rating Scale for Depression), and validated measures of other predictors. RESULTS: Patients with baseline minor and subsyndromal depression were more depressed than the non-depressed group at follow-up: They had a 7.0-fold (95% CI 4.5-10.8) risk of developing major depression, and a one-year adjusted Hamilton Depression Score of 11.0 (95% CI 10.2-11.8) compared with 7.8 (95% CI 7.1-8.5) for the non-depressed group; these outcomes were less severe than those of the major depression group. Independent predictors of depression outcomes included race, psychiatric and physical functioning, and social support. CONCLUSIONS: Minor and subsyndromal depression are likely to persist, and pose an elevated risk of worsening over one year. Clinicians and preventive interventions researchers should focus on modifiable risks, such as psychiatric functioning or social support, in elders suffering clinically significant depressive symptoms.

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  • Onset of functional decline leads to increased depressive symptoms over time in older adults.

    “there is evidence that onset of functional decline leads to increased depressive symptoms over time in older adults. (Kennedy, Kelman, and Thomas 1990;Lyness, Chapman, McGriff, Drayer, and Duberstein 2009;Roberts, Kaplan, Shema, and Strawbridge 1997;Yang and George 2005)”

    From Successful aging: Advancing the science of physical independence in older adults (2015) · cites this paper as Lyness et al. 2009

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  1. Williams JBW 1988 A structured interview guide for the Hamilton depression rating scale Archives of General Psychiatry 45 742 747 3395203

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Authors
Lyness, J. M., Chapman, B. P., McGriff, J., Drayer, R., & Duberstein, P. R.
Affiliations
University of Rochester Medicine (US)
Corresponding author
Lyness, Jeffrey M.
ORCID
Venue
International Psychogeriatrics
Publisher
Elsevier BV
Published
2009-02
Volume
21
Issue
1
Pages
60-68
ISSN
1041-6102 (ISSN-L)
DOI
10.1017/s1041610208007746
PMC
PMC2745243
OpenAlex
W2159531352
Cited by
96
References
32
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2023: 3 · 2021: 2 · 2020: 5 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 12 · 2014: 11 · 2013: 11 · 2012: 8
FWCI
10.22
Type
journal article
Language
en
Open access
Licence
Locations
  • International Psychogeriatrics (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (5r01mh061429-05)
  • National Institute on Aging (K08AG031328)
  • National Institute of Mental Health (K24MH71509, K24MH072712, R01 MH-61429, R01 MH-061429, K24MH071509, T32MH073452)
Topics
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
minor depression, subthreshold depression, older adults, primary care, depression severity, social support, psychiatric functioning, physical function, race
MeSH terms
Activities of Daily Living, Aged, Aged, 80 and over, Antidepressive Agents, Cross-Sectional Studies, Dementia, Depression, Major Depressive Disorder, Depressive Disorder, Family Practice, Female, Follow-Up Studies, Humans, Internal Medicine, Male, New York, Personality Inventory, Primary Health Care, Psychometrics, Social Support, Geriatric Assessment, Comorbidity, Treatment Outcome

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