Family history of associated disorders in patients with postural tachycardia syndrome
Abstract
Introduction: Postural tachycardia syndrome is more frequently being recognised in adolescents and adults. However, its pathophysiology remains undefined. We evaluated our database for patterns in family history of clinical symptoms and associated disorders in these patients. Materials and methods: Patients with postural tachycardia syndrome diagnosed in our clinic between 2014 and 2018 and who were less than 19 years at diagnosis were included. The history was reviewed for family members with postural tachycardia syndrome, dizziness and/or syncope, joint hypermobility with or without hypermobile Ehlers–Danlos syndrome, and autoimmune disorders. Statistical analysis assessed the entire cohort plus differences in gender, presence or absence of joint hypermobility, and presence or absence of familial autoimmune disease. Results: A total of 579 patients met inclusion criteria. We found that 14.2% of patients had a family member with postural tachycardia syndrome, with male patients more likely to have an affected family member (20% versus 12.7%, p = 0.04). If the patient also had joint hypermobility, male patients were more likely to have a family member with postural tachycardia syndrome (25% versus 12.6%, p = 0.017), more than one affected family member (7.1% versus 0.74%, p = 0.001), and a family member with joint hypermobility (37.5% versus 23.7%, p = 0.032). Autoimmune disease was seen in 45.1% of family members, but more likely in female patients with concurrent hypermobility (21.1% versus 8.9%, p = 0.035). Discussion: This in-depth analysis of associated familial disorders in patients with postural tachycardia syndrome offers further insight into the pathophysiology of the disorder, and informs further screening of family members in these patients.
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As many as 14% of POTS patients have a family member with POTS, 31% have a family member with orthostatic intolerance, 20% have a family member with joint hypermobility, and 45% have a family member with autoimmune disease.
“As many as 14% of POTS patients have a family member with POTS, 31% have a family member with orthostatic intolerance, 20% have a family member with joint hypermobility, and 45% have a family member with autoimmune disease (Boris et al., 2020).”
From Postural orthostatic tachycardia syndrome (POTS): State of the science and clinical care from a 2019 National Institutes of Health Expert Consensus Meeting - Part 1 (2021) · cites this paper as Boris et al., 2020
POTS patients and their close relatives have a higher than expected prevalence of autoimmune disorders including celiac disease, Hashimoto's thyroiditis, Sjögren's syndrome, and systemic lupus erythematosus.
“POTS patients (Vernino and Stiles, 2018) and their close relatives (Boris et al., 2020; Shaw et al., 2019) have a higher than expected prevalence of autoimmune disorders including celiac disease (Penny et al., 2016), Hashimoto’s thyroiditis (Blitshteyn, 2015), Sjögren’s syndrome (Goodman et al., 2017), and systemic lupus erythematosus (SLE) (Tang et al., 2004).”
From Postural orthostatic tachycardia syndrome (POTS): State of the science and clinical care from a 2019 National Institutes of Health Expert Consensus Meeting - Part 1 (2021) · cites this paper as Boris et al., 2020
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Vernino, S., Bourne, K. M., Stiles, L. E., Grubb, B. P., Fedorowski, A., Stewart, J. M., Arnold, A. C., Pace, L. A., Axelsson, J., Boris, J. R., et al. (2021) · Autonomic Neuroscience · doi:10.1016/j.autneu.2021.102828 · Cited by 304 · see citing works
Self-citation
- Authors
- Boris, J. R., Huang, J., Shuey, T., & Bernadzikowski, T.
- Affiliations
- Children's Hospital of Philadelphia (US)
- Corresponding author
- Bernadzikowski, Thomas
- Venue
- Cardiology in the Young
- Publisher
- Cambridge University Press (CUP)
- Published
- 2020-02-03
- Volume
- 30
- Issue
- 3
- Pages
- 388-394
- ISSN
- 1047-9511 (ISSN-L)
- 1467-1107
- OpenAlex
- W3004865637
- Cited by
- 12
- References
- 10
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 1
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cardiology in the Young (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Keywords
- postural orthostatic tachycardia syndrome, family history (medicine), joint hypermobility, hypermobile Ehlers-Danlos syndrome, autoimmune disease, dizziness, syncope, family screening, sex differences, pathophysiology
- MeSH terms
- Adolescent, Ehlers-Danlos Syndrome, Female, Humans, Joint Instability, Male, Medical History Taking, Philadelphia, Postural Orthostatic Tachycardia Syndrome
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