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Cited by 50Antiplatelet Therapy and Cardiovascular DiseasesAcute Myocardial Infarction ResearchTrauma and Emergency Care Studies

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Prehospital Use of Aspirin Rarely Is Associated with Adverse Events

Quan, Dan, LoVecchio, Frank, Clark, Bryan, Gallagher, John V.·2004·Prehospital and Disaster Medicine
DOI 10.1017/s1049023x00001990
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Abstract

Introduction: Aspirin is commonly administered for acute coronary syndromes in the prehospital setting. Few studies have addressed the incidence of adverse effects associated with prehospital administration of aspirin. Objective: To determine the incidence of adverse events following the administration of aspirin by prehospital personnel. Methods: Multi-center, retrospective, case series that involved all patients who received aspirin in the prehospital setting from (01 August 1999–31 January 2000). Patient encounter forms of the emergency medical services (EMS) of a metropolitan fire department were reviewed. All patients who had a potential cardiac syndrome (i.e., chest pain, dyspnea) as documented on the EMS forms were included in the review. Exclusion criteria included failure to meet inclusion criteria, and chest pain secondary to apparent noncardiac causes (i.e., trauma). Hospital charts were reviewed from a subset of patients at the participating hospitals. The major outcome was an adverse event following prehospital administration of aspirin. This outcome was evaluated during the EMS encounter, at emergency department discharge, or at six and 24-hours post-aspirin ingestion. An adverse event secondary to aspirin ingestion was defined as anaphylaxis or allergic reactions, such as rash or respiratory changes. Results: A total of 25,600 EMS encounter forms were reviewed, yielding 2,399 patients with a potential cardiac syndrome. Prior to EMS arrival, 585 patients had received aspirin, and 893 were administered aspirin by EMS personnel. No patients had an adverse event during the EMS encounter. Of these patients, 229 were transported to participating hospitals and 219 medical records were available for review with no adverse reactions recorded during their hospital course. Conclusion: Aspirin is rarely associated with adverse events when administered by prehospital personnel for presumed coronary syndromes.

Overview

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Registry

Crossref · 10.1017/s1049023x00001990

Cites

25 of 25 references verified0 citation errors · 0 not checkable

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Citations

Cites

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Research works printed but not linked: 2

  1. Speer, 1981, Baptist J: Aspirin allergy, Annals of Allergy, 46, 123
  2. 1988, Randomized trial of intravenous streptokinase, oral aspirin, or neither among 17,187 cases of suspected acute myocardial infarction, Lancet, 2, 349

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Metadata

Authors
Quan, D., LoVecchio, F., Clark, B., & Gallagher, J. V.
Affiliations
  • Midwestern University (US)
  • Maricopa Medical Center (US)
  • Arizona Game and Fish Department (US)
ORCID
Venue
Prehospital and Disaster Medicine
Publisher
Cambridge University Press (CUP)
Published
2004-12
Volume
19
Issue
4
Pages
362-365
ISSN
  • 0882-7397 (ISSN-L)
  • 1049-023X
  • 1945-1938
DOI
10.1017/s1049023x00001990
OpenAlex
W1987629452
Cited by
50
References
25
Citations by year
2024: 4 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 2 · 2017: 1 · 2015: 15 · 2014: 1 · 2013: 2 · 2012: 1
FWCI
0.65
Type
journal article
Language
en
Open access
closed
Licence
www.cambridge.org/core/terms (unspecified, 2766 d)
Locations
  • Prehospital and Disaster Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Antiplatelet Therapy and Cardiovascular Diseases
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
  • Health Sciences › Medicine › Emergency Medicine › Trauma and Emergency Care Studies
Keywords
aspirin, prehospital administration, adverse drug reactions, acute coronary syndrome, emergency medical services, anaphylaxis, allergic reactions, chest pain, drug safety
MeSH terms
Aspirin, Chest Pain, Drug Hypersensitivity, Emergency Medical Services, Emergency Treatment, Female, Humans, Male, Platelet Aggregation Inhibitors, Prognosis, Retrospective Studies, Sampling Studies, Incidence, Treatment Outcome, Risk Assessment

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