Diurnal variations of extrapyramidal symptoms induced by haloperidol in schizophrenic subjects
Open accessAbstract
Despite the fact that the circadian variations in the density of striatal dopaminergic D2 receptors are well documented, there are few reports concerning whether these variations may regulate the extrapyramidal symptoms produced by antipsychotic drugs. To test this hypothesis, we selected 18 male hospitalized schizophrenic subjects, who had been treated for 2 wk with 10 mg haloperidol three times a day. The extrapyramidal symptoms were evaluated 1 h after each haloperidol administration (e.g. 09:00, 14:00 and 19:00 hours). The diurnal profiles of haloperidol-induced extrapyramidal symptoms showed that akathisia and dystonia were milder in the morning and increased in severity during the night. However, Parkinsonian symptoms were more severe during the morning evaluations than during the evening tests. The difference in the diurnal pattern of the haloperidol-induced side-effects, suggests that receptor-related mechanisms with a different circadian profile contribute to the induction of the extrapyramidal symptoms.
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Drug-induced evocation of extrapyramidal symptoms, akathisia and dystonia, in patients with schizophrenia was more severe at night compared to the morning hours.
“Drug-induced evocation of extrapyramidal symptoms, akathisia and dystonia, in patients with schizophrenia was more severe at night compared to the morning hours36.”
From Diurnal rhythms of wrist temperature are associated with future disease risk in the UK Biobank (2023) · cites this paper as [36]
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Cites
Effects of antipsychotic drugs on serotonin receptors.
Meltzer, H. Y., & Nash, J. F. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06671-2 · Cited by 259 · see citing works
A Controlled Trial of Amantadine in Drug-Induced Extrapyramidal Disorders
DiMascio, A. (1976) · Archives of General Psychiatry · doi:10.1001/archpsyc.1976.01770050055008 · Cited by 124 · see citing works
Mao, C. C., Cheney, D. L., Marco, E., et al. (1977) · Brain Research · doi:10.1016/0006-8993(77)90431-0 · Cited by 103 · see citing works
Circadian rhythms in rat brain neurotransmitter receptors.
Kafka, M., Wirz‐Justice, A., Naber, D., et al. (1983) · PubMed · Cited by 102 · see citing works
Concepts in Chronopharmacology
Reinberg, A. (1992) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.32.040192.000411 · Cited by 98 · see citing works
Motor fluctuations during continuous levodopa infusions in patients with Parkinson's disease
Nutt, J. G., Carter, J. H., Lea, E. S., & Woodward, W. R. (1997) · Movement Disorders · doi:10.1002/mds.870120304 · Cited by 93 · see citing works
Nocturnal akathisia in parkinson's disease: Treatment with clozapine
Linazasoro, G., Martí-Massó, J. F., & Suárez, J. A. (1993) · Movement Disorders · doi:10.1002/mds.870080209 · Cited by 61 · see citing works
DiMascio, A., & Shader, R. I. (1969) · American Journal of Psychiatry · doi:10.1176/ajp.126.6.796 · Cited by 45 · see citing works
Sack, D. A. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800260076010 · Cited by 42 · see citing works
Circadian pattern of acute, neuroleptic-induced dystonic reactions
Mazurek, M. F., & Rosebush, P. I. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.5.708 · Cited by 42 · see citing works
Dávila, R., Zumárraga, M., Andı́a, I., et al. (1989) · Life Sciences · doi:10.1016/0024-3205(89)90339-1 · Cited by 30 · see citing works
Zimmerman, T. R., Sage, J. I., Lang, A. E., & Mark, M. H. (1994) · Movement Disorders · doi:10.1002/mds.870090208 · Cited by 21 · see citing works
Diurnal variation in tardive dyskinesia
Hyde, T. M., Egan, M. F., Brown, R. J., et al. (1995) · Psychiatry Research · doi:10.1016/0165-1781(94)02662-3 · Cited by 16 · see citing works
Haloperidol Concentrations in Saliva and Serum: Determination by the Radioimmunoassay Method
Yamazumi, S., & Miura, S. (2017) · International Pharmacopsychiatry · doi:10.1159/000468492 · Cited by 11 · see citing works
Once versus Thrice Daily Thiothixene in the Treatment of Schizophrenic In-Patients
Lee, J. H., Branchey, M. H., Haher, E. J., et al. (1974) · The British Journal of Psychiatry · doi:10.1192/bjp.125.1.73 · Cited by 7 · see citing works
Morning variations of plasma homovanillic acid in untreated schizophrenic patients
Zumárraga, M., Andı́a, I., Bárcena, B., et al. (1993) · Journal of Psychiatric Research · doi:10.1016/0022-3956(93)90045-4 · Cited by 6 · see citing works
Chronopharmacological Studies of Neuroleptics
Nagayama, H., Takagi, A., & Takahashi, R. (1981) · Springer eBooks · doi:10.1007/978-94-011-8123-5_7 · Cited by 6 · see citing works
Torner, C., Sánchez‐Hurtado, L. A., & Aguilar‐Roblero, R. A. (1998) · Biological Rhythm Research · doi:10.1076/brhm.29.5.538.4817 · Cited by 5 · see citing works
Self-citationPazo, J. H., Rascovsky, S., Jerusalinsky, D. A., et al. (1989) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(89)90325-x · Cited by 5 · see citing works
Ortega-Soto, H. A., Jasso, A., Ceceña, G., et al. (1991) · Salud Mental · Cited by 3 · see citing works
Asynchrony in the Diurnal Rhythms of Dopaminergic D2 Receptors in Different Brain Regions of the Rat
Torner, C., & Aguilar‐Roblero, R. A. (2001) · Biological Rhythm Research · doi:10.1076/brhm.32.3.363.1341 · Cited by 2 · see citing works
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Research works printed but not linked: 1
- Nagayama H, Takagi A, Takahashi R (1981). Chrono- pharmacological studies of neuroleptics. In: Saletu B, Berner P, Hollister L (Eds.), Current Developments in Psychopharmacology vol. 6 (pp. 191-214). New York : Spectrum.
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Diurnal rhythms of wrist temperature are associated with future disease risk in the UK Biobank
Brooks, T. G., Lahens, N. F., Grant, G. R., Sheline, Y. I., FitzGerald, G. A., & Skarke, C. (2023) · Nature Communications · doi:10.1038/s41467-023-40977-5 · Cited by 57 · see citing works
- Authors
- Torner, C., Herrera-Estrella, M., Gutiérrez, J. A., & Aguilar-Roblero, R.
- Affiliations
- Universidad Autónoma Metropolitana (MX)
- Corresponding author
- Torner, Carlos
- ORCID
- Torner, Carlos
- Venue
- The International Journal of Neuropsychopharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-09
- Volume
- 6
- Issue
- 3
- Pages
- 243-246
- ISSN
- 1461-1457 (ISSN-L)
- 1469-5111
- OpenAlex
- W2045180143
- Cited by
- 8
- References
- 21
- Citations by year
- 2023: 1 · 2022: 1 · 2020: 1 · 2019: 1 · 2014: 3
- FWCI
- 0.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The International Journal of Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- extrapyramidal symptoms, haloperidol, schizophrenia, diurnal variation, circadian rhythm, akathisia, dystonia, parkinsonism, dopamine D2 receptor, antipsychotic adverse effects, striatum
- MeSH terms
- Adult, Basal Ganglia Diseases, Circadian Rhythm, Cross-Sectional Studies, Dystonia, Haloperidol, Humans, Male, Psychiatric Status Rating Scales, Schizophrenia, Schizophrenic Psychology, Antipsychotic Agents, Akathisia, Drug-Induced
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