The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Adhesion of Plasmodium falciparum-infected erythrocytes to human cells: molecular mechanisms and therapeutic implications
Open accessAbstract
Severe malaria has a high mortality rate (15–20%) despite treatment with effective antimalarial drugs. Adjunctive therapies for severe malaria that target the underlying disease process are therefore urgently required. Adhesion of erythrocytes infected with Plasmodium falciparum to human cells has a key role in the pathogenesis of life-threatening malaria and could be targeted with antiadhesion therapy. Parasite adhesion interactions include binding to endothelial cells (cytoadherence), rosetting with uninfected erythrocytes and platelet-mediated clumping of infected erythrocytes. Recent research has started to define the molecular mechanisms of parasite adhesion, and antiadhesion therapies are being explored. However, many fundamental questions regarding the role of parasite adhesion in severe malaria remain unanswered. There is strong evidence that rosetting contributes to severe malaria in sub-Saharan Africa; however, the identity of other parasite adhesion phenotypes that are implicated in disease pathogenesis remains unclear. In addition, the possibility of geographic variation in adhesion phenotypes causing severe malaria, linked to differences in malaria transmission levels and host immunity, has been neglected. Further research is needed to realise the untapped potential of antiadhesion adjunctive therapies, which could revolutionise the treatment of severe malaria and reduce the high mortality rate of the disease.
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Su, X.-Z., Heatwole, V. M., Wertheimer, S. P., Guinet, F., Herrfeldt, J. A., Peterson, D. S., Ravetch, J. A., & Wellems, T. E. (1995) · Cell · doi:10.1016/0092-8674(95)90055-1 · Cited by 1,219
Smith, J. D., Chitnis, C. E., Craig, A. G., Roberts, D. J., Hudson-Taylor, D. E., Peterson, D. S., Pinches, R., Newbold, C. I., & Miller, L. H. (1995) · Cell · doi:10.1016/0092-8674(95)90056-x · Cited by 1,005
Malaria in pregnancy: pathogenesis and immunity
Rogerson, S. J., Hviid, L., Duffy, P. E., Leke, R. F., & Taylor, D. W. (2007) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(07)70022-1 · Cited by 628
Rapid switching to multiple antigenic and adhesive phenotypes in malaria
Roberts, D. J., Craig, Berendt, A. R., Pinches, R., Nash, G., Marsh, K., & Newbold, C. I. (1992) · Nature · doi:10.1038/357689a0 · Cited by 619
Cockburn, I. A., Mackinnon, M. J., O'Donnell, A., Allen, S. J., Moulds, J. M., Baisor, M., Bockarie, M., Reeder, J. C., & Rowe, J. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305306101 · Cited by 255
Self-citationBruneel, F., Hocqueloux, L., Alberti, C., Wolff, M., Chevret, S., Bédos, J.-P., Durand, R., Le Bras, J., Régnier, B., & Vachon, F. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200206-631oc · Cited by 207
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Microglia development and function
Nayak, D., Roth, T. L., & McGavern, D. B. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120240 · Cited by 1,154
Severe malaria is associated with parasite binding to endothelial protein C receptor
Turner, L., Lavstsen, T., Berger, S. S., Wang, C. W., Petersen, J. E. V., Avril, M., Brazier, A. J., Freeth, J., Jespersen, J. S., Nielsen, M. A., et al. (2013) · Nature · doi:10.1038/nature12216 · Cited by 559
Lavstsen, T., Turner, L., Saguti, F., Magistrado, P., Rask, T. S., Jespersen, J. S., Wang, C. W., Berger, S. S., Baraka, V., Marquard, A. M., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120455109 · Cited by 269
Extracellular vesicles: mediators and biomarkers of pathology along CNS barriers
Ramirez, S. H., Andrews, A. M., Paul, D., & Pachter, J. S. (2018) · Fluids and Barriers of the CNS · doi:10.1186/s12987-018-0104-7 · Cited by 128
Khunrae, P., Dahlbäck, M., Nielsen, M. A., Andersen, G., Ditlev, S. B., Resende, M., Pinto, V. V., Theander, T. G., Higgins, M. K., & Salanti, A. (2010) · Journal of Molecular Biology · doi:10.1016/j.jmb.2010.01.040 · Cited by 121
Metadata
- Authors
- Rowe, J. A., Claessens, A., Corrigan, R. A., & Arman, M.
- Venue
- Expert Reviews in Molecular Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2009-05
- Volume
- 11
- Pages
- e16-e16
- ISSN
- 1462-3994 (ISSN-L)
- OpenAlex
- W2165158644
- Cited by
- 372
- References
- 6
- FWCI
- 21.61
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Rowe, J. A., Claessens, A., Corrigan, R. A., & Arman, M. (2009). Adhesion of Plasmodium falciparum-infected erythrocytes to human cells: molecular mechanisms and therapeutic implications. Expert Reviews in Molecular Medicine. https://doi.org/10.1017/s1462399409001082
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
