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Coupling High-Pressure MALDI with Ion Mobility/Orthogonal Time-of-Flight Mass Spectrometry
Abstract
A new ion mobility/time-of-flight mass spectrometer employing a high-pressure MALDI source has been designed and tested. The prototype instrument operates at a source/drift cell pressure of 1-10 Torr helium, resulting in a mobility resolution of approximately 25. A small time-of-flight mass spectrometer (20 cm) with a mass resolution of up to 200 has been attached to the drift cell to identify (in terms of mass-to-charge ratio) the separated ions. A simple tripeptide mixture has been separated in the drift tube and mass identified as singly protonated species. The ability to separate peptide mixtures, e.g., tryptic digest of a protein, is illustrated and compared to results obtained on a high-vacuum time-of-flight instrument.
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Citations
Cited by
Ion mobility–mass spectrometry
Kanu, A. B., Dwivedi, P., Tam, M., Matz, L., & Hill, H. H. (2008) · Journal of Mass Spectrometry · doi:10.1002/jms.1383 · Cited by 1,154
Protein Complexes in the Gas Phase: Technology for Structural Genomics and Proteomics
Benesch, J. L. P., Ruotolo, B. T., Simmons, D. A., & Robinson, C. V. (2007) · Chemical Reviews · doi:10.1021/cr068289b · Cited by 408
Self-citationIon Mobility Spectrometry: Principles and Applications
Borsdorf, H., & Eiceman, G. A. (2006) · Applied Spectroscopy Reviews · doi:10.1080/05704920600663469 · Cited by 395
Ion mobility–mass spectrometry: a new paradigm for proteomics
McLean, J. A., Ruotolo, B. T., Gillig, K. J., & Russell, D. H. (2005) · International Journal of Mass Spectrometry · doi:10.1016/j.ijms.2004.10.003 · Cited by 309
Self-citationSpontaneous Anti-Resolution in Heterochiral Clusters of Serine
Julian, R. R., Myung, S., & Clemmer, D. E. (2004) · Journal of the American Chemical Society · doi:10.1021/ja031516w · Cited by 42
Metadata
- Authors
- Gillig, K. J., Ruotolo, B., Stone, E. G., Russell, D. H., Fuhrer, K., Gonin, M., & Schultz, A. J.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2000-07-29
- Volume
- 72
- Issue
- 17
- Pages
- 3965-3971
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W1977768873
- Cited by
- 162
- References
- 0
- FWCI
- 4.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gillig, K. J., Ruotolo, B., Stone, E. G., Russell, D. H., Fuhrer, K., Gonin, M., & Schultz, A. J. (2000). Coupling High-Pressure MALDI with Ion Mobility/Orthogonal Time-of-Flight Mass Spectrometry. Analytical Chemistry. https://doi.org/10.1021/ac0005619
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