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Quartz crystal microbalance for the detection of microgram quantities of human serum albumin: relationship between the frequency change and the mass of protein adsorbed
Abstract
We have developed a piezoelectric immunosensor for the detection of microalbumin. Human serum albumin (HSA) in the range 0.1-100 micrograms mL-1 could be detected using a flow cell; the immunosensor is sensitive enough to monitor levels of albuminuria. The immunosensor did not respond to bovine serum albumin, only to HSA, implying that the specificity for HSA was high. We investigated the relationship between the frequency change (delta F) and adsorption per unit area of piezoelectrically active quartz crystal (delta M). delta M was estimated with radioisotope-labeled anti-HSA or HSA. When anti-HSA was adsorbed onto the surface of the crystal or HSA was bound to anti-HSA supported by the crystal, values of magnitude of delta F/delta M were larger than the value predicted from theory (Sauerbrey's equation). Furthermore, magnitude of delta F/delta M for HSA was larger than that for anti-HSA.
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Cited by
Höök, F., Kasemo, B., Nylander, T., Fant, C., Sott, K., & Elwing, H. (2001) · Analytical Chemistry · doi:10.1021/ac0106501 · Cited by 1,162
Commercial quartz crystal microbalances – theory and applications
O’Sullivan, C. K., & Guilbault, G. G. (1999) · Biosensors and Bioelectronics · doi:10.1016/s0956-5663(99)00040-8 · Cited by 658
Overview of Piezoelectric Biosensors, Immunosensors and DNA Sensors and Their Applications
Pohanka, M. (2018) · Materials · doi:10.3390/ma11030448 · Cited by 384
Aponte, V. M., Finch, D. S., & Klaus, D. M. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.04.007 · Cited by 51
Nanofiber‐Based Chemical Sensors
Andrady, A. L. (2022) · Applications of Polymer Nanofibers · doi:10.1002/9781119267713.ch4 · Cited by 5
Metadata
- Authors
- Muratsugu, M., Ohta, F., Miya, Y., Hosokawa, T., Kurosawa, S., Kamo, N., & Ikeda, H.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1993-10-15
- Volume
- 65
- Issue
- 20
- Pages
- 2933-2937
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W1995311659
- Cited by
- 233
- References
- 0
- FWCI
- 4.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Quartz crystal microbalance for the detection of microgram quantities of human serum albumin: relationship between the frequency change and the mass of protein adsorbed. https://app.cochat.ai/papers/10.1021/ac00068a036
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- Muratsugu, M., Ohta, F., Miya, Y., Hosokawa, T., Kurosawa, S., Kamo, N., & Ikeda, H. (1993). Quartz crystal microbalance for the detection of microgram quantities of human serum albumin: relationship between the frequency change and the mass of protein adsorbed. Analytical Chemistry. https://doi.org/10.1021/ac00068a036
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