Considerations for non-invasive in-flight monitoring of astronaut immune status with potential use of MEMS and NEMS devices
Abstract
The dynamics of how astronauts' immune systems respond to space flight have been studied extensively, but the complex process has not to date been thoroughly characterized, nor have the underlying principles of what causes the immune system to change in microgravity been fully determined. Statistically significant results regarding overall immunological effects in space have not yet been established due to the relatively limited amount of experimental data available, and are further complicated by the findings not showing systematically reproducible trends. Collecting in vivo data during flight without affecting the system being measured would increase understanding of the immune response process. The aims of this paper are to briefly review the current knowledge regarding how the immune system is altered in space flight; to present a group of candidate biomarkers that could be useful for in-flight monitoring and give an overview of the current methods used to measure these markers; and finally, to further establish the need and usefulness of incorporating real-time analytical techniques for in-flight assessment of astronaut health, emphasizing the potential application of MEMS/NEMS devices.
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The combined effects of weightlessness and radiation exposure on the immune system are a major risk of extended space travel.
“A major risk of extended space travel is the combined effects of weightlessness and radiation exposure on the immune system.”
From Hindlimb suspension and spe-like radiation impairs clearance of bacterial infections (2014) · cites this paper as [3]
Space flight alters immune responses, certain of which could lead to potentially detrimental pathology.
“Space flight has been shown to alter immune responses, certain of which could lead to potentially detrimental pathology.”
From Hindlimb suspension and spe-like radiation impairs clearance of bacterial infections (2014) · cites this paper as [3]
Cites
1 retracted
Li, W., Haiyan, X., Zhi-xiong, X., et al. (2004) · Journal of Biochemical and Biophysical Methods · doi:10.1016/j.jbbm.2003.10.005 · Cited by 5 · see citing works
RetractedQuantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
Michalet, X., Pinaud, F. F., Bentolila, L. A., Tsay, J. M., Doose, S., Li, J. J., Sundaresan, G., Wu, A. M., Gambhir, S. S., & Weiss, S. (2005) · Science · doi:10.1126/science.1104274 · Cited by 7,794 · see citing works
Nanobelts of Semiconducting Oxides
Pan, Z., Dai, Z. R., & Wang, Z. L. (2001) · Science · doi:10.1126/science.1058120 · Cited by 5,830 · see citing works
Nanowire Nanosensors for Highly Sensitive and Selective Detection of Biological and Chemical Species
Cui, Y., Wei, Q., Park, H., & Lieber, C. M. (2001) · Science · doi:10.1126/science.1062711 · Cited by 5,799 · see citing works
In vivo cancer targeting and imaging with semiconductor quantum dots
Gao, X., Cui, Y., Levenson, R. M., Chung, L. W. K., & Nie, S. (2004) · Nature Biotechnology · doi:10.1038/nbt994 · Cited by 4,775 · see citing works
El‐Sayed, I. H., Huang, X., & El‐Sayed, M. A. (2005) · Nano Letters · doi:10.1021/nl050074e · Cited by 1,920 · see citing works
Translating Biomolecular Recognition into Nanomechanics
Fritz, J., Baller, M. K., Lang, H. P., Rothuizen, H. E., VETTIGER, P., Meyer, E., Güntherodt, H. ‐., Gerber, C., & Gimzewski, J. K. (2000) · Science · doi:10.1126/science.288.5464.316 · Cited by 1,650 · see citing works
Covalently functionalized nanotubes as nanometre- sized probes in chemistry and biology
Wong, S. S., Joselevich, E., Woolley, A. T., et al. (1998) · Nature · doi:10.1038/27873 · Cited by 1,456 · see citing works
Chemical Amplification: Continuous-Flow PCR on a Chip
Kopp, M. U., de Mello, A. J., & Manz, A. (1998) · Science · doi:10.1126/science.280.5366.1046 · Cited by 1,213 · see citing works
Torre-Amione, G., Kapadia, S., Benedict, C., Oral, H., Young, J. B., & Mann, D. L. (1996) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00589-7 · Cited by 1,211 · see citing works
A reversibly antigen-responsive hydrogel
Miyata, T., Asami, N., & Uragami, T. (1999) · Nature · doi:10.1038/21619 · Cited by 1,167 · see citing works
Cantilever transducers as a platform for chemical and biological sensors
Lavrik, N. V., Sepaniak, M. J., & Datskos, P. G. (2004) · Review of Scientific Instruments · doi:10.1063/1.1763252 · Cited by 1,117 · see citing works
Electrochemical Biosensing Platforms Using Platinum Nanoparticles and Carbon Nanotubes
Hrapovic, S., Liu, Y., Male, K. B., et al. (2003) · Analytical Chemistry · doi:10.1021/ac035143t · Cited by 1,064 · see citing works
McAllister, D. V., Wang, P. M., Davis, S. P., Park, J.-H., Canatella, P. J., Allen, M. G., & Prausnitz, M. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2331316100 · Cited by 859 · see citing works
Klein, B., Zhang, X., Jourdan, M., Content, J., Houssiau, F., Aarden, L. A., Piechaczyk, M., & Bataille, R. (1989) · Blood · doi:10.1182/blood.v73.2.517.517 · Cited by 763 · see citing works
Patolsky, F., & Lieber, C. M. (2005) · Materials Today · doi:10.1016/s1369-7021(05)00791-1 · Cited by 705 · see citing works
McKendry, R. A., Zhang, J., Arntz, Y., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152330199 · Cited by 599 · see citing works
Structure and Function of Enzymes Adsorbed onto Single-Walled Carbon Nanotubes
Karajanagi, S. S., Vertegel, A. A., Kane, R. S., & Dordick, J. S. (2004) · Langmuir · doi:10.1021/la047994h · Cited by 508 · see citing works
Survey of the year 2003 commercial optical biosensor literature
Rich, R. L., & Myszka, D. G. (2004) · Journal of Molecular Recognition · doi:10.1002/jmr.726 · Cited by 505 · see citing works
Dual-mode mechanical resonance of individual ZnO nanobelts
Bai, X., Gao, P., Wang, Z. L., & Wang, E. G. (2003) · Applied Physics Letters · doi:10.1063/1.1587878 · Cited by 495 · see citing works
Evidence for beneficial low level radiation effects and radiation hormesis
Feinendegen, L. E. (2005) · British Journal of Radiology · doi:10.1259/bjr/63353075 · Cited by 469 · see citing works
Wang, Z. L. (2004) · Annual Review of Physical Chemistry · doi:10.1146/annurev.physchem.55.091602.094416 · Cited by 458 · see citing works
The mechanisms of estrogen regulation of bone resorption
Riggs, B. L. (2000) · Journal of Clinical Investigation · doi:10.1172/jci11468 · Cited by 447 · see citing works
Single cell detection with micromechanical oscillators
Ilic, B., Czaplewski, D. A., Zalalutdinov, M. K., Craighead, H. G., Neužil, P., Campagnolo, C., & Batt, C. A. (2001) · Journal of Vacuum Science & Technology B Microelectronics and Nanometer Structures Processing Measurement and Phenomena · doi:10.1116/1.1421572 · Cited by 442 · see citing works
Evaluation of MEMS materials of construction for implantable medical devices
Kotzar, G., Freas, M., Abel, P. B., Fleischman, A. J., Roy, S., Zorman, C. A., Moran, J. M., & Melzak, J. M. (2002) · Biomaterials · doi:10.1016/s0142-9612(02)00007-8 · Cited by 440 · see citing works
Chemical Sensors and Biosensors for Medical and Biological Applications
Spichiger‐Keller, U. E. (1998) · Wiley eBooks · doi:10.1002/9783527612284 · Cited by 419 · see citing works
Systemic inflammatory response to exhaustive exercise : Cytokine kinetics
鈴木, 克. (2002) · Medical Entomology and Zoology · Cited by 416 · see citing works
Ziegler, C. (2004) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-004-2694-y · Cited by 414 · see citing works
Label-free protein assay based on a nanomechanical cantilever array
Arntz, Y., Seelig, J., Lang, H. P., et al. (2002) · Nanotechnology · doi:10.1088/0957-4484/14/1/319 · Cited by 409 · see citing works
Bioaffinity Sensing Using Biologically Functionalized Conducting-Polymer Nanowire
Ramanathan, K., Bangar, M. A., Yun, M., Chen, W., Myung, N. V., & Mulchandani, A. (2004) · Journal of the American Chemical Society · doi:10.1021/ja044486l · Cited by 401 · see citing works
Salivary cortisol measurement: a practical approach to assess pituitary-adrenal function.
LAUDAT, M. H., CERDAS, S., FOURNIER, C., GUIBAN, D., GUILHAUME, B., & LUTON, J. P. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-66-2-343 · Cited by 393 · see citing works
Roy, I., & Gupta, M. N. (2003) · Chemistry & Biology · doi:10.1016/j.chembiol.2003.12.004 · Cited by 372 · see citing works
Amino acid functionalisation of water soluble carbon nanotubes
Georgakilas, V. I., Tagmatarchis, N., Pantarotto, D., et al. (2002) · Chemical Communications · doi:10.1039/b209843a · Cited by 343 · see citing works
Fiber-optic biosensors – an overview
Marazuela, M. D., & Moreno‐Bondi, M. C. (2002) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-002-1235-9 · Cited by 343 · see citing works
Salivary IgA levels and infection risk in elite swimmers
Gleeson, M., MCDONALD, W. A., Pyne, D. B., Cripps, A. W., FRANCIS, J. L., Fricker, P. A., & Clancy, R. L. (1999) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199901000-00012 · Cited by 327 · see citing works
Frenken, J. W. M., Oosterkamp, T. H., Hendriksen, B. L. M., & Rost, M. J. (2005) · Materials Today · doi:10.1016/s1369-7021(05)00842-4 · Cited by 324 · see citing works
Ye, L., & Haupt, K. (2004) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-003-2450-8 · Cited by 318 · see citing works
Suzuki, K., Yamada, M., Kurakake, S., Okamura, N., Yamaya, K., Liu, Q., Kudoh, S., Kowatari, K., Nakaji, S., & Sugawara, K. (2000) · European Journal of Applied Physiology · doi:10.1007/s004210050044 · Cited by 317 · see citing works
Nanoparticle labels in immunosensing using optical detection methods
Seydack, M. (2004) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2004.11.003 · Cited by 313 · see citing works
Femtogram mass detection using photothermally actuated nanomechanical resonators
Lavrik, N. V., & Datskos, P. G. (2003) · Applied Physics Letters · doi:10.1063/1.1569050 · Cited by 311 · see citing works
Biomarkers of some pulmonary diseases in exhaled breath
Kharitonov, S. A., & Barnes, P. J. (2002) · Biomarkers · doi:10.1080/13547500110104233 · Cited by 288 · see citing works
Johnston, R. S., Dietlein, L. F., & Berry, C. A. (2011) · NASA Technical Reports Server (NASA) · Cited by 287 · see citing works
Glucose Biosensor Based on the Microcantilever
Pei, J., Tian, F., & Thundat, T. G. (2003) · Analytical Chemistry · doi:10.1021/ac035048k · Cited by 286 · see citing works
A mixed self-assembled monolayer-based surface plasmon immunosensor for detection of E. coli O157:H7
Subramanian, A., Irudayaraj, J., & Ryan, T. E. (2005) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2005.03.007 · Cited by 281 · see citing works
Stress-induced subclinical reactivation of varicella zoster virus in astronauts
Mehta, S. K., Cohrs, R. J., Forghani, B., Zerbe, G., Gilden, D. H., & Pierson, D. L. (2004) · Journal of Medical Virology · doi:10.1002/jmv.10555 · Cited by 275 · see citing works
Plastic antibodies: developments and applications
Haupt, K., & Mosbach, K. (1998) · Trends in biotechnology · doi:10.1016/s0167-7799(98)01222-0 · Cited by 273 · see citing works
Collings, A. F., & Caruso, F. (1997) · Reports on Progress in Physics · doi:10.1088/0034-4885/60/11/005 · Cited by 258 · see citing works
Simkó, M., & Mattsson, M. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20198 · Cited by 256 · see citing works
Direct optical sensors: principles and selected applications
Gauglitz, G. (2004) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-004-2895-4 · Cited by 245 · see citing works
Ilyas, M., & Mahgoub, I. (2006) · Cited by 234 · see citing works
Muratsugu, M., Ohta, F., Miya, Y., Hosokawa, T., Kurosawa, S., Kamo, N., & Ikeda, H. (1993) · Analytical Chemistry · doi:10.1021/ac00068a036 · Cited by 233 · see citing works
Microcantilever-based biosensors
Moulin, A. M., O'Shea, S. J., & Welland, M. E. (2000) · Ultramicroscopy · doi:10.1016/s0304-3991(99)00145-x · Cited by 232 · see citing works
Lang, H. P., Hegner, M., & Gerber, C. (2005) · Materials Today · doi:10.1016/s1369-7021(05)00792-3 · Cited by 227 · see citing works
Influence of diabetes mellitus on heart failure risk and outcome
Bauters, C., Lamblin, N., Fadden, E. P. M., BELLE, E. V., Millaire, A., & de Groote, P. (2003) · Cardiovascular Diabetology · doi:10.1186/1475-2840-2-1 · Cited by 213 · see citing works
Hughes, W. L., & Wang, Z. L. (2003) · Applied Physics Letters · doi:10.1063/1.1570497 · Cited by 210 · see citing works
Affinity Imaging of Red Blood Cells Using an Atomic Force Microscope
Grandbois, M., Dettmann, W., Benoit, M., et al. (2000) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540004800516 · Cited by 207 · see citing works
Murphy, M. B. (2003) · Nucleic Acids Research · doi:10.1093/nar/gng110 · Cited by 205 · see citing works
Th2 cytokines and asthma: an introduction
Barnes, P. J. (2001) · Respiratory Research · doi:10.1186/rr39 · Cited by 203 · see citing works
High-sensitivity miniaturized immunoassays for tumor necrosis factor ? using microfluidic systems
Cesaro-Tadic, S., Dernick, G., Juncker, D., et al. (2004) · Lab on a Chip · doi:10.1039/b408964b · Cited by 202 · see citing works
Calcium metabolism before, during, and after a 3-mo spaceflight: kinetic and biochemical changes
Smith, S. M., Wastney, M. E., Morukov, B. V., Larina, I. M., Nyquist, L. E., Abrams, S. A., Taran, E. N., Shih, C.-Y., Nillen, J. L., Davis-Street, J. E., et al. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.277.1.r1 · Cited by 196 · see citing works
Epstein–Barr virus shedding by astronauts during space flight
Pierson, D. L., Stowe, R. P., Phillips, T. M., Lugg, D. J., & Mehta, S. K. (2004) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2004.08.001 · Cited by 181 · see citing works
Artificial antibodies to corticosteroids prepared by molecular imprinting
Ramström, O., Ye, L., & Mosbach, K. (1996) · Chemistry & Biology · doi:10.1016/s1074-5521(96)90095-2 · Cited by 179 · see citing works
Pharmaceutical applications for molecularly imprinted polymers
Allender, C. J., Richardson, C., Woodhouse, B., et al. (2000) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(99)00355-5 · Cited by 165 · see citing works
Enzyme linked immunosorbent assay on a microchip with electrochemical detection
Rossier, J. S., & Girault, H. H. (2001) · Lab on a Chip · doi:10.1039/b104772h · Cited by 165 · see citing works
Changes in neutrophil functions in astronauts
Kaur, I., Simons, E. R., Castro, V. A., Ott, C. M., & Pierson, D. L. (2003) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2003.10.005 · Cited by 158 · see citing works
Immune function during space flight
Sonnenfeld, G., & Shearer, W. T. (2002) · Nutrition · doi:10.1016/s0899-9007(02)00903-6 · Cited by 155 · see citing works
Rapid and sensitive biosensor for Salmonella
Pathirana, S., Barbaree, J. M., Chin, B. A., et al. (2000) · Biosensors and Bioelectronics · doi:10.1016/s0956-5663(00)00067-1 · Cited by 155 · see citing works
Leukocyte subsets and neutrophil function after short-term spaceflight
Stowe, R. P., Sams, C. F., Mehta, S. K., Kaur, I., Jones, M. L., Feeback, D. L., & Pierson, D. L. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.65.2.179 · Cited by 152 · see citing works
A novel immunosensor for herpes viruses
Koenig, B., & Graetzel, M. (1994) · Analytical Chemistry · doi:10.1021/ac00075a005 · Cited by 141 · see citing works
Elevated Stress Hormone Levels Relate to Epstein-Barr Virus Reactivation in Astronauts
Stowe, R. P., Pierson, D. L., & Barrett, A. D. T. (2001) · Psychosomatic Medicine · doi:10.1097/00006842-200111000-00007 · Cited by 140 · see citing works
Bokken, G. C. A. M., Corbee, R. J., Knapen, F. V., et al. (2003) · FEMS Microbiology Letters · doi:10.1016/s0378-1097(03)00250-7 · Cited by 140 · see citing works
Energy expenditure and balance during spaceflight on the space shuttle
Stein, T. P., Leskiw, M. J., Schluter, M. D., Hoyt, R. W., Lane, H. W., Gretebeck, R. C.-I., & LeBlanc, A. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.6.r1739 · Cited by 139 · see citing works
Comparison of the QCM and the SPR method for surface studies and immunological applications
Köβlinger, C., Uttenthaler, E., Drost, S., et al. (1995) · Sensors and Actuators B Chemical · doi:10.1016/0925-4005(95)85023-6 · Cited by 138 · see citing works
Crucian, B. E., Cubbage, M. L., & Sams, C. F. (2000) · Journal of Interferon & Cytokine Research · doi:10.1089/10799900050044741 · Cited by 137 · see citing works
Biochemical and immunological markers of over-training.
Gleeson, M. (2002) · Europe PMC (PubMed Central) · Cited by 135 · see citing works
The effect of hypogravity and hypergravity on cells of the immune system
Cogoli, A. (1993) · Journal of Leukocyte Biology · doi:10.1002/jlb.54.3.259 · Cited by 134 · see citing works
Samyn, N., & van Haeren, C. (2000) · International Journal of Legal Medicine · doi:10.1007/s004140050287 · Cited by 132 · see citing works
Microgravity and immune responsiveness
Borchers, A. T., Keen, C. L., & Gershwin, M. E. (2002) · Nutrition · doi:10.1016/s0899-9007(02)00913-9 · Cited by 125 · see citing works
T cell activation responses are differentially regulated during clinorotation and in spaceflight
Hashemi, B. B., Penkala, J. E., Vens, C., Huls, H. M., Cubbage, M., & Sams, C. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.14.2071 · Cited by 125 · see citing works
Immune responses and latent herpesvirus reactivation in spaceflight.
Stowe, R. P., Mehta, S. K., Ferrando, A. A., Feeback, D. L., & Pierson, D. L. (2001) · PubMed · Cited by 124 · see citing works
Ruan, C., Zeng, K., Varghese, O. K., et al. (2003) · Analytical Chemistry · doi:10.1021/ac034562n · Cited by 122 · see citing works
DNA biosensors based on self-assembled carbon nanotubes
Wang, S., Wang, R., Sellin, P. J., et al. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.10.188 · Cited by 122 · see citing works
Skládal, P. (2003) · Journal of the Brazilian Chemical Society · doi:10.1590/s0103-50532003000400002 · Cited by 114 · see citing works
Microchip-based enzyme-linked immunosorbent assay (microELISA) system with thermal lens detection
Sato, K., Yamanaka, M., Hagino, T., et al. (2004) · Lab on a Chip · doi:10.1039/b411356j · Cited by 112 · see citing works
Micromechanical thermogravimetry
Berger, R., Lang, H. P., Gerber, C., et al. (1998) · Chemical Physics Letters · doi:10.1016/s0009-2614(98)00817-3 · Cited by 111 · see citing works
The Immune Function During Space Flight
Huey, C., Jones, H. P., & Howard, C. A. (2018) · Digital Commons @ UNT Health Science Center · Cited by 110 · see citing works
Low Dose γ-Rays Activate Immune Functions via Induction of Glutathione and Delay Tumor Growth
Kojima, S., Keiko, N., & ISHIDA, H. (2004) · Journal of Radiation Research · doi:10.1269/jrr.45.33 · Cited by 108 · see citing works
Antarctic isolation: Immune and viral studies
Tingate, T. R., Lugg, D. J., Muller, H. K., et al. (1997) · Immunology and Cell Biology · doi:10.1038/icb.1997.42 · Cited by 104 · see citing works
Gonzalez, B. E., Mercado, C. K., Johnson, L., Brodsky, N. L., & Bhandari, V. (2003) · Journal of Perinatal Medicine · doi:10.1515/jpm.2003.009 · Cited by 101 · see citing works
The role of noradrenaline in depression: a review.
Leonard, B. E. (1997) · PubMed · Cited by 101 · see citing works
Effects of mission duration on neuroimmune responses in astronauts.
Stowe, R. P., Sams, C. F., & Pierson, D. L. (2003) · PubMed · Cited by 100 · see citing works
Lyte, M., & Ernst, S. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1068 · Cited by 100 · see citing works
Sustained microgravity reduces intrinsic wound healing and growth factor responses in the rat
Davidson, J. M., Aquino, A. M., WOODWARD, S. C., & Wilfinger, W. W. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.2.325 · Cited by 99 · see citing works
Opportunities for nutritional amelioration of radiation-induced cellular damage
Turner, N. D., Braby, L. A., Ford, J. R., & Lupton, J. R. (2002) · Nutrition · doi:10.1016/s0899-9007(02)00945-0 · Cited by 98 · see citing works
Free-running rhythms of melatonin, cortisol, electrolytes, and sleep in humans in Antarctica
Kennaway, D. J., & Dorp, C. F. V. (1991) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1991.260.6.r1137 · Cited by 95 · see citing works
Standoff Detection of Chemicals Using Porous Silicon “Smart Dust” Particles
Schmedake, T. A., Cunin, F., Link, J. R., et al. (2002) · Advanced Materials · doi:10.1002/1521-4095(20020916)14:18 · Cited by 95 · see citing works
Overview of spaceflight immunology studies
TAYLOR, G. R. (1993) · Journal of Leukocyte Biology · doi:10.1002/jlb.54.3.179 · Cited by 95 · see citing works
Nutrition in spaceflight and weightlessness models
Lane, H. W., & Schoeller, D. A. (2000) · CRC Press eBooks · Cited by 92 · see citing works
Palinkas, L. A., Gunderson, E. K. E., Holland, A. W., et al. (2000) · PubMed · Cited by 89 · see citing works
The immune system in space and microgravity
Sonnenfeld, G. (2002) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200212000-00024 · Cited by 89 · see citing works
Molecular imprints as artificial antibodies — a new generation of chemical sensors
Dickert, F. L., Lieberzeit, P. A., & Tortschanoff, M. (2000) · Sensors and Actuators B Chemical · doi:10.1016/s0925-4005(99)00327-5 · Cited by 88 · see citing works
Oral Fluids as an Alternative to Serum for Measurement of Markers of Immune Activation
Nishanian, P., Aziz, N., Chung, J., Detels, R., & Fahey, J. L. (1998) · Clinical and Diagnostic Laboratory Immunology · doi:10.1128/cdli.5.4.507-512.1998 · Cited by 88 · see citing works
Immuno‐Carbon Nanotubes and Recognition of Pathogens
Elkin, T., Jiang, X., Taylor, S., et al. (2005) · ChemBioChem · doi:10.1002/cbic.200400337 · Cited by 87 · see citing works
Luminescent Nanoparticle Probes for Bioimaging
Santra, S., Xu, J., Wang, K., et al. (2004) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2004.017 · Cited by 87 · see citing works
Highly sensitive quartz crystal immunosensors for multisample detection of herbicides
Yokoyama, K., Ikebukuro, K., Tamiya, E., et al. (1995) · Analytica Chimica Acta · doi:10.1016/0003-2670(94)00579-b · Cited by 86 · see citing works
Th1 and Th2 cytokine responses to academic stress
Kang, D.-H., & Fox, C. C. (2001) · Research in Nursing & Health · doi:10.1002/nur.1027 · Cited by 84 · see citing works
Space analogue studies in Antarctica
Lugg, D. J., & Shepanek, M. A. (1999) · Acta Astronautica · doi:10.1016/s0094-5765(99)00068-5 · Cited by 84 · see citing works
Real-Time, label-free monitoring of tumor antigen and serum antibody interactions
Campagnolo, C., Meyers, K. J., Ryan, T. E., Atkinson, R. C., Chen, Y., Scanlan, M. J., Ritter, G., Old, L. J., & Batt, C. A. (2004) · Journal of Biochemical and Biophysical Methods · doi:10.1016/j.jbbm.2004.05.006 · Cited by 83 · see citing works
Adaptive response studies may help choose astronauts for long-term space travel
Mortazavi, S. M. J., CAMERON, J. R., & Niroomand‐Rad, A. (2003) · Advances in Space Research · doi:10.1016/s0273-1177(03)00089-9 · Cited by 78 · see citing works
Neuroendocrine and immune system responses with spaceflights
Tipton, C. M., GREENLEAF, J. E., & Jackson, C. G. R. (1996) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199608000-00009 · Cited by 77 · see citing works
Stsiapura, V. I., Sukhanova, A. V., Artemyev, M. V., Pluot, M., Cohen, J. H. M., Baranov, A. V., Олейников, В. А., & Nabiev, I. R. (2004) · Analytical Biochemistry · doi:10.1016/j.ab.2004.07.006 · Cited by 76 · see citing works
Excretion of IL-6 by astronauts during spaceflight
Stein, T. P., & Schluter, M. D. (1994) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1994.266.3.e448 · Cited by 76 · see citing works
GlycoChip: multiarray for the study of carbohydrate-binding proteins
Galanina, O. E., Mecklenburg, M., Nifantiev, N. E., et al. (2003) · Lab on a Chip · doi:10.1039/b305963d · Cited by 74 · see citing works
The role of psychoneuroendocrine factors on spaceflight-induced immunological alterations
Meehan, R., Whitson, R., & Sams, C. (1993) · Journal of Leukocyte Biology · doi:10.1002/jlb.54.3.236 · Cited by 73 · see citing works
Gravity Effects on Single Cells: Techniques, Findings, and Theory
Cogoli, A., & Gmünder, F. K. (1991) · Advances in space biology and medicine · doi:10.1016/s1569-2574(08)60125-2 · Cited by 72 · see citing works
In situ detection of calcium ions with chemically modified microcantilevers
Ji, H. (2002) · Biosensors and Bioelectronics · doi:10.1016/s0956-5663(01)00270-6 · Cited by 72 · see citing works
Cellular immunity in cosmonauts during long duration spaceflight on board the orbital MIR station.
Gmünder, F. K., Konstantinova, I., Cogoli, A., Lesnyak, A. T., Bogomolov, W., & Grachov, A. W. (1994) · PubMed · Cited by 72 · see citing works
Analysis of force curves obtained on the live cell membrane using chemically modified AFM probes
Afrin, R., Yamada, T., & Ikai, A. (2004) · Ultramicroscopy · doi:10.1016/j.ultramic.2004.01.013 · Cited by 71 · see citing works
MACKINNON, L. T. (1992) · Medical Entomology and Zoology · Cited by 70 · see citing works
Proteomic applications of surface plasmon resonance biosensors: analysis of protein arrays
Yuk, J. S., & Ha, K. (2005) · Experimental & Molecular Medicine · doi:10.1038/emm.2005.1 · Cited by 70 · see citing works
Flamme, A. C. L., & Pearce, E. J. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.10.5829 · Cited by 68 · see citing works
Effects of spaceflight on levels and activity of immune cells.
Sonnenfeld, G., Mandel, A. D., Konstantinova, I., TAYLOR, G. R., Berry, W. D., Wellhausen, S. R., Lesnyak, A. T., & Fuchs, B. B. (1990) · PubMed · Cited by 66 · see citing works
Initial Animal Studies of a Wireless, Batteryless, MEMS Implant for Cardiovascular Applications
Najafi, N., & Ludomirsky, A. (2004) · Biomedical Microdevices · doi:10.1023/b:bmmd.0000013367.30870.4e · Cited by 66 · see citing works
Fiber Optic Sensors: An Overview
Davis, C. M. (1985) · Optical Engineering · doi:10.1117/12.7973482 · Cited by 63 · see citing works
Space flight, microgravity, stress, and immune responses
Sonnenfeld, G. (1999) · Advances in Space Research · doi:10.1016/s0273-1177(99)00455-x · Cited by 63 · see citing works
Inhibited interferon-gamma but normal interleukin-3 production from rats flown on the space shuttle.
Gould, C. L., Lyte, M., Williams, J. V., Mandel, A. D., & Sonnenfeld, G. (1987) · PubMed · Cited by 62 · see citing works
Kim, M., Shin, Y., Jung, J., et al. (2005) · Journal of Immunological Methods · doi:10.1016/j.jim.2004.12.007 · Cited by 60 · see citing works
Prolonged Weightlessness and Humoral Immunity
Voss, E. W. (1984) · Science · doi:10.1126/science.6729476 · Cited by 60 · see citing works
Gravitational physiology of human immune cells: a review of in vivo, ex vivo and in vitro studies.
Cogoli, A. (1996) · PubMed · Cited by 59 · see citing works
Plasma and urine catecholamine levels in cosmonauts during long-term stay on Space Station Salyut-7
Květňanský, R., Davydova, N. A., Noskov, V. B., et al. (1988) · Acta Astronautica · doi:10.1016/0094-5765(88)90020-3 · Cited by 57 · see citing works
Fisman, E. Z., Motro, M., & Tenenbaum, A. (2003) · Cardiovascular Diabetology · doi:10.1186/1475-2840-2-11 · Cited by 55 · see citing works
Banerjee, S., & Wong, S. S. (2004) · Chemical Communications · doi:10.1039/b404204b · Cited by 53 · see citing works
Nutrition and renal stone disease in space
Zerwekh, J. E. (2002) · Nutrition · doi:10.1016/s0899-9007(02)00911-5 · Cited by 53 · see citing works
Aviles, H., Belay, T., Fountain, K., Vance, M., & Sonnenfeld, G. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00968.2002 · Cited by 53 · see citing works
Skeletal unloading causes organ-specific changes in immune cell responses
Armstrong, J. W., Nelson, K. A., Simske, S., Luttges, M. W., IANDOLO, J. J., & Chapes, S. K. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.75.6.2734 · Cited by 52 · see citing works
Anzai, K., Furuse, M., Yoshida, A., et al. (2004) · Journal of Radiation Research · doi:10.1269/jrr.45.319 · Cited by 52 · see citing works
Natural killer cells after altaïr mission
Konstantinova, I. V., Петровна, Р. М., Meshkov, D., Peres, C. A., Husson, D., & Schmitt, D. (1995) · Acta Astronautica · doi:10.1016/0094-5765(95)00161-1 · Cited by 50 · see citing works
Rapid detection of Escherichia coli using a separated electrode piezoelectric crystal sensor
He, F., Geng, Q., Zhu, W., et al. (1994) · Analytica Chimica Acta · doi:10.1016/0003-2670(94)90007-w · Cited by 50 · see citing works
Avilés, H., Belay, T., Vance, M., Sun, B., & Sonnenfeld, G. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00259.2004 · Cited by 50 · see citing works
Effects of space flight and IGF-1 on immune function
Chapes, S. K., Simske, S. J., Forsman, A. D., et al. (1999) · Advances in Space Research · doi:10.1016/s0273-1177(99)00456-1 · Cited by 48 · see citing works
A Piezoelectric Immunosensor for the Detection of Cortisol
Attili, B. S., & Suleiman, A. A. (1995) · Analytical Letters · doi:10.1080/00032719508000035 · Cited by 48 · see citing works
Shearer, W. T., Lee, B.-N., Cron, S. G., Rosenblatt, H. M., Smith, E. O., Lugg, D. J., Nickolls, P. M., Sharp, R. M., Rollings, K., & Reuben, J. M. (2002) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2002.123873 · Cited by 47 · see citing works
Suri, C. R., Jain, P. K., & Mishra, G. C. (1995) · Journal of Biotechnology · doi:10.1016/0168-1656(94)00136-z · Cited by 47 · see citing works
Immune Responses in Space Flight
Sonnenfeld, G. (1998) · International Journal of Sports Medicine · doi:10.1055/s-2007-971992 · Cited by 47 · see citing works
Shearer, W. T., Lugg, D. J., Rosenblatt, H. M., Nickolls, P. M., Sharp, R., Reuben, J. M., & Ochs, H. D. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.112269 · Cited by 47 · see citing works
Hematological and immunological changes during space flight
Cogoli, A. (1981) · Acta Astronautica · doi:10.1016/0094-5765(81)90070-9 · Cited by 45 · see citing works
Effect of the Antarctic environment on hormone levels and mood of Chinese expeditioners
Xu, C., Guangjin, Z., Quanfu, X., Shandong, Z., Guoyuan, D., Yanzhen, X., & Palinkas, L. A. (2003) · International Journal of Circumpolar Health · doi:10.3402/ijch.v62i3.17562 · Cited by 44 · see citing works
Head-down tilt bed rest and immune responses
Schmitt, D., Schwarzenberg, M., Tkaczuk, J., et al. (2000) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240000349 · Cited by 42 · see citing works
TH1-biased immunity induced by exposure to Antarctic winter
Shirai, T., Magara, K. K., Motohashi, S., Yamashita, M., Kimura, M. Y., Suwazomo, Y., Nogawa, K., Kuriyama, T., Taniguchi, M., & Nakayama, T. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2003.1504 · Cited by 41 · see citing works
Lymphatic tissue changes in rats flown on Spacelab Life Sciences-2
Congdon, C. C., Allebban, Z., Gibson, L. A., Kaplansky, A. S., Strickland, K. M., Jago, T. L., Johnson, D., Lange, R. D., & Ichiki, A. T. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.81.1.172 · Cited by 40 · see citing works
Ou, L., See, L., Wu, C.-J., et al. (2002) · Clinical Rheumatology · doi:10.1007/s100670200012 · Cited by 38 · see citing works
The immune system in space and other extreme conditions
Konstantinova, I., & Fuchs, B. (1991) · Medical Entomology and Zoology · Cited by 37 · see citing works
Effect of spaceflight on natural killer cell activity
Петровна, Р. М., Sonnenfeld, G., Lesnyak, A. T., TAYLOR, G. R., Meshkov, D., Mandel, A. D., Medvedev, A. E., Berry, W. D., Fuchs, B. B., & Konstantinova, I. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.73.2.s196 · Cited by 37 · see citing works
Spaceflight and development of immune responses
Sonnenfeld, G., Foster, M., Morton, D. S., Bailliard, F., Fowler, N., Hakenewerth, A. M., Bates, R., & Miller, E. S. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.4.1429 · Cited by 36 · see citing works
Immunosuppression during spaceflight deconditioning.
Levine, D. S., & GREENLEAF, J. E. (1998) · PubMed · Cited by 35 · see citing works
Dynamic Microcantilever Sensors for Discerning Biomolecular Interactions
Tian, F., Hansen, K. M., Ferrell, T. L., et al. (2005) · Analytical Chemistry · doi:10.1021/ac048602e · Cited by 34 · see citing works
Immune responses during an antarctic summer
Lugg, D. J., Ursin, H., Donovan, K., et al. (1995) · Pathology · doi:10.1080/00313029500169852 · Cited by 34 · see citing works
Regulation of Interleukin-6 Secretion from Mononuclear Blood Cells by Extracellular Calcium
Bornefalk, E., Ljunghall, S., Lindh, E., et al. (1997) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1997.12.2.228 · Cited by 34 · see citing works
Characteristics of human dendritic cells generated in a microgravity analog culture system
Savary, C. A., Grazziutti, M., Przepiorka, D., Tomasovic, S. P., McIntyre, B. W., Woodside, D. G., Pellis, N. R., Pierson, D. L., & Rex, J. H. (2001) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/bf02577532 · Cited by 34 · see citing works
Will a chip every day keep the doctor away?
Canham, L., & Aston, R. (2001) · Physics World · doi:10.1088/2058-7058/14/7/31 · Cited by 34 · see citing works
Antarctica: a review of recent medical research
Olson, J. J. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(02)02087-4 · Cited by 33 · see citing works
Effect of Space Flight on Cytokine Production and Other Immunologic Parameters of Rhesus Monkeys
Sonnenfeld, G., DAVIS, S., TAYLOR, G. R., Mandel, A. D., Konstantinova, I., Lesnyak, A. T., FUCHS, B. B., PERES, C., TKACKZUK, J., & Schmitt, D. (1996) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1996.16.409 · Cited by 32 · see citing works
Hässig, A., Wen-Xi, L. L., & Stämpfli, K. (1996) · Medical Hypotheses · doi:10.1016/s0306-9877(96)90130-9 · Cited by 28 · see citing works
Evaluation of Salivary Antibodies to Detect Infection with Helicobacter pylori
Loeb, M. B., Riddell, R. H., James, C., Hunt, R. H., & Smaill, F. (1997) · Canadian Journal of Gastroenterology · doi:10.1155/1997/294081 · Cited by 26 · see citing works
Thymic involution in the suspended rat: adrenal hypertrophy and glucocorticoid receptor content.
Steffen, J. M., & Musacchia, X. J. (1986) · PubMed · Cited by 24 · see citing works
[Behavior-immunity relationship: the role of cytokines].
Espinosa, E., & Bermúdez‐Rattoni, F. (2001) · PubMed · Cited by 24 · see citing works
Thyroid function during a prolonged stay in Antarctica
Sawhney, R. C., Malhotra, A. S., Nair, C. S., Bajaj, A. C., Rajan, K. C., Pal, K., Prasad, R., & Basu, M. (1995) · European Journal of Applied Physiology · doi:10.1007/bf00964127 · Cited by 24 · see citing works
Inhibited interferon production after space flight.
Sonnenfeld, G., Gould, C. L., Williams, J. V., & Mandel, A. D. (1988) · PubMed · Cited by 23 · see citing works
Animal models for the study of the effects of spaceflight on the immune system
Sonnenfeld, G. (2003) · Advances in Space Research · doi:10.1016/s0273-1177(03)90383-8 · Cited by 23 · see citing works
Isolation and confinement as a model for spaceflight Immune changes
Schmitt, D., & Schaffar, L. (1993) · Journal of Leukocyte Biology · doi:10.1002/jlb.54.3.209 · Cited by 23 · see citing works
Effect of simulated microgravity on human lymphocytes.
Bakos, A., Varkonyi, A., Minárovits, J., et al. (2001) · PubMed · Cited by 21 · see citing works
Role of cytokines in hyperoxia mediated inflammation in the developing lung
Kotecha, S. (2003) · Frontiers in bioscience · doi:10.2741/1113 · Cited by 20 · see citing works
Trends in mucosal immunity in Antarctica during six Australian winter expeditions
Francis, J. L., Gleeson, M., Lugg, D. J., et al. (2002) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.2002.01104.x · Cited by 19 · see citing works
Baum, M., & Liesen, H. (1997) · Der Orthopäde · doi:10.1007/pl00003352 · Cited by 18 · see citing works
Problems in the interpretation of HIV-1 viral load assays using commercial reagents
O’Shea, S., Chrystie, I. L., Cranston, R., Mullen, J. E., Corbett, K. M., Murphy, G., Parry, J. V., de Ruiter, A., & Banatvala, J. E. (2000) · Journal of Medical Virology · doi:10.1002/(sici)1096-9071(200006)61:2 · Cited by 18 · see citing works
Immunoaffinity beads for selective removal of cholesterol from human plasma
Yavuz, H., & Deni̇zli̇, A. (2003) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856203766652020 · Cited by 15 · see citing works
Immune response during space flight
Criswell-Hudak, B. S. (1991) · Experimental Gerontology · doi:10.1016/0531-5565(91)90022-e · Cited by 14 · see citing works
Influence of suspension on the oxidative burst by rat neutrophils
Miller, E. S., Koebel, D. A., Davis, S. A., Klein, J. B., McLeish, K. R., Goldwater, D. J., & Sonnenfeld, G. (1994) · Journal of Applied Physiology · doi:10.1152/jappl.1994.76.1.387 · Cited by 13 · see citing works
Pathophysiology: Principles of Disease
Miller, M. J. (1983) · Medical Entomology and Zoology · Cited by 12 · see citing works
Functional capacity of neutrophil granulocytes in deep-sea divers
Benestad, H. B., Hersleth, I. B., Hardersen, H., et al. (1990) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365519009091559 · Cited by 12 · see citing works
Microelectromechanical systems in urology
Kristo, B., Liao, J. C., Neves, H. P., et al. (2003) · Urology · doi:10.1016/s0090-4295(03)00032-3 · Cited by 12 · see citing works
[Is the immune system our sixth sense? Relation between the immune and neuroendocrine systems].
Ferencĭk, M., & Štvrtinová, V. (1997) · PubMed · Cited by 11 · see citing works
Exercise training prevents the inflammatory response to hypoxia in cremaster venules
Orth, T. A., Allen, J., Wood, J. G., et al. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00694.2004 · Cited by 11 · see citing works
Role of nutrition during long-term spaceflight
Heer, M. A., Zittermann, A., & Hoetzel, D. (1995) · Acta Astronautica · doi:10.1016/0094-5765(95)98734-q · Cited by 9 · see citing works
Bio Sphere: Finding cancer cells with quantum dots
SAGE, L. C. (2004) · Analytical Chemistry · doi:10.1021/ac041673t · Cited by 8 · see citing works
Research opportunities on immunocompetence in space
Beisel, W. R., & Talbot, J. M. (1985) · NASA STI Repository (National Aeronautics and Space Administration) · Cited by 7 · see citing works
Bounds in the Sensitivity of BioMEMS Devices for Cell Detection
Bhalerao, K. D., Mwenifumbo, S., Soboyejo, A. B. O., et al. (2004) · Biomedical Microdevices · doi:10.1023/b:bmmd.0000013362.62700.d2 · Cited by 7 · see citing works
Cell mediated immunity and alcohol intake in Antarctic wintering personnel
Thom, O., & Lugg, D. J. (2002) · International Journal of Circumpolar Health · doi:10.3402/ijch.v61i3.17454 · Cited by 6 · see citing works
Functional capacity of neutrophil granulocytes in deep-sea divers
Benestad, H. B., Hersleth, I. B., Hardersen, H., et al. (1990) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365519009091559 · Cited by 6 · see citing works
Simultaneous multiwavelength detection based on surface plasmon resonance technique
Zhao, X., Wang, Z., Mu, Y., et al. (2000) · Laboratory Robotics and Automation · doi:10.1002/(sici)1098-2728(2000)12:2 · Cited by 5 · see citing works
Vernikos-Danellis, J. (1995) · Acta Astronautica · doi:10.1016/0094-5765(95)98733-p · Cited by 5 · see citing works
Papadakos, P. J., & Haitsma, J. J. (2004) · CHEST Journal · doi:10.1378/chest.125.6.1980 · Cited by 4 · see citing works
Speculation on a role for photoimmunosuppression during space missions
Hug, D. H., Hunter, J. K., & Dunkerson, D. D. (2001) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/s1011-1344(00)00147-0 · Cited by 2 · see citing works
Modeling Calcium Loss from Bones During Space Flight
Wastney, M. E., Morukov, B. V., Larina, I. M., et al. (1999) · NASA Technical Reports Server (NASA) · Cited by 1 · see citing works
Chapter 7 Teaching of Space Life Sciences
Schmitt, D., Françon, P., & Lee, P. H. U. (1999) · Advances in space biology and medicine · doi:10.1016/s1569-2574(08)60011-8 · Cited by 1 · see citing works
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Horneck, G., Klaus, D. M., & Mancinelli, R. L. (2010) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00016-09 · Cited by 619 · see citing works
Self-citationBiological effects of space radiation and development of effective countermeasures
Kennedy, A. R. (2014) · Life Sciences in Space Research · doi:10.1016/j.lssr.2014.02.004 · Cited by 188 · see citing works
Lunar habitats: A brief overview of issues and concepts
Benaroya, H. (2017) · REACH · doi:10.1016/j.reach.2018.08.002 · Cited by 113 · see citing works
Hindlimb suspension and spe-like radiation impairs clearance of bacterial infections
Li, M., Holmes, V., Zhou, Y., Ni, H., Sanzari, J. K., Kennedy, A. R., & Weissman, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085665 · Cited by 43 · see citing works
- Authors
- Aponte, V. M., Finch, D. S., & Klaus, D. M.
- Affiliations
- University of Colorado Boulder (US)
- Corresponding author
- Aponte, V.M.
- ORCID
- Klaus, D.M.
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 2006-08
- Volume
- 79
- Issue
- 14
- Pages
- 1317-1333
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W2034113973
- Cited by
- 51
- References
- 195
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 5 · 2016: 2 · 2015: 5 · 2014: 3 · 2013: 1 · 2012: 4
- FWCI
- 0.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Johnson Space Center
- Topics
- Health Sciences › Medicine › Physiology › Spaceflight effects on biology
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Space Technology and Applications
- Physical Sciences › Engineering › Aerospace Engineering › Space Exploration and Technology
- Keywords
- spaceflight immunology, microgravity, in-flight monitoring, biomarkers, MEMS devices, real-time analytics, astronaut health monitoring, immune response
- MeSH terms
- Animals, Cells, Cultured, Humans, Immunity, Space Flight, Weightlessness, Monitoring, Immunologic, Biomarkers, Cytokines, Weightlessness Simulation, Nanotechnology
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