Cited by 51Spaceflight effects on biologySpace Technology and ApplicationsSpace Exploration and Technology

Considerations for non-invasive in-flight monitoring of astronaut immune status with potential use of MEMS and NEMS devices

Aponte, V.M., Finch, D.S., Klaus, D.M.·2006·Life Sciences

Abstract

The dynamics of how astronauts' immune systems respond to space flight have been studied extensively, but the complex process has not to date been thoroughly characterized, nor have the underlying principles of what causes the immune system to change in microgravity been fully determined. Statistically significant results regarding overall immunological effects in space have not yet been established due to the relatively limited amount of experimental data available, and are further complicated by the findings not showing systematically reproducible trends. Collecting in vivo data during flight without affecting the system being measured would increase understanding of the immune response process. The aims of this paper are to briefly review the current knowledge regarding how the immune system is altered in space flight; to present a group of candidate biomarkers that could be useful for in-flight monitoring and give an overview of the current methods used to measure these markers; and finally, to further establish the need and usefulness of incorporating real-time analytical techniques for in-flight assessment of astronaut health, emphasizing the potential application of MEMS/NEMS devices.

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Crossref · 10.1016/j.lfs.2006.04.007

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Authors
Aponte, V. M., Finch, D. S., & Klaus, D. M.
Affiliations
University of Colorado Boulder (US)
Corresponding author
Aponte, V.M.
Venue
Life Sciences
Publisher
Elsevier BV
Published
2006-08
Volume
79
Issue
14
Pages
1317-1333
ISSN
0024-3205 (ISSN-L)
OpenAlex
W2034113973
Cited by
51
References
195
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 5 · 2016: 2 · 2015: 5 · 2014: 3 · 2013: 1 · 2012: 4
FWCI
0.27
Type
journal article
Language
en
Open access
closed
Locations
  • Life Sciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
Johnson Space Center
Topics
  • Health Sciences › Medicine › Physiology › Spaceflight effects on biology
  • Physical Sciences › Engineering › Electrical and Electronic Engineering › Space Technology and Applications
  • Physical Sciences › Engineering › Aerospace Engineering › Space Exploration and Technology
Keywords
spaceflight immunology, microgravity, in-flight monitoring, biomarkers, MEMS devices, real-time analytics, astronaut health monitoring, immune response
MeSH terms
Animals, Cells, Cultured, Humans, Immunity, Space Flight, Weightlessness, Monitoring, Immunologic, Biomarkers, Cytokines, Weightlessness Simulation, Nanotechnology

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