The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Amperometric Monitoring of Stimulated Catecholamine Release from Rat Pheochromocytoma (PC12) Cells at the Zeptomole Level
Abstract
Catecholamine release from rat pheochromocytoma (PC12) cells has been observed at zeptomole levels using dc-amperometric detection with carbon fiber microelectrodes. Time-resolved individual exocytic events from PC12 cells have been recorded and analyzed with 1.2 ms time resolution. The average area under 1912 current transients from 13 PC12 cells corresponds to 190 zmol (114,300 molecules per release event). The average width at half-height of these current transients is 9.3 ms, in agreement with the time frame of exocytosis. The detection limit of the method reported here is as low as 31 zmol. This is the first report of direct electrochemical observation of quantal release from PC12 cells. The successful application of this electrochemical scheme to monitor catecholamines released from small vesicles also suggests that it may be possible to apply this technique to monitor quantal release from synaptic vesicles.
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Cites
Wightman, R. M., Jankowski, J. A., Kennedy, R. T., Kawagoe, K. T., Schroeder, T. J., Leszczyszyn, D. J., Near, J. A., Diliberto, E. J., & Viveros, O. H. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10754 · Cited by 893
Cited by
Sulzer, D., Chen, T., Lau, Y., Kristensen, H., Rayport, S., & Ewing, A. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-05-04102.1995 · Cited by 688
Self-citationPurinergic Signalling: ATP Release
Bodin, P., & Burnstock, G. (2001) · Neurochemical Research · doi:10.1023/a:1012388618693 · Cited by 521
Electrochemical Monitoring of Single Cell Secretion: Vesicular Exocytosis and Oxidative Stress
Amatore, C., Arbault, S., Guille, M., & Lemaître, F. (2008) · Chemical Reviews · doi:10.1021/cr068062g · Cited by 406
Analysis of exocytotic events recorded by amperometry
Mosharov, E. V., & Sulzer, D. (2005) · Nature Methods · doi:10.1038/nmeth782 · Cited by 349
Huang, L., Shen, H., Atkinson, M. A., & Kennedy, R. T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.21.9608 · Cited by 107
Metadata
- Authors
- Chen, T. K., Luo, G., & Ewing, A. G.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1994-10-01
- Volume
- 66
- Issue
- 19
- Pages
- 3031-3035
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2021633739
- Cited by
- 180
- References
- 1
- FWCI
- 6.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Amperometric Monitoring of Stimulated Catecholamine Release from Rat Pheochromocytoma (PC12) Cells at the Zeptomole Level. https://app.cochat.ai/papers/10.1021/ac00091a007
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- Chen, T. K., Luo, G., & Ewing, A. G. (1994). Amperometric Monitoring of Stimulated Catecholamine Release from Rat Pheochromocytoma (PC12) Cells at the Zeptomole Level. Analytical Chemistry. https://doi.org/10.1021/ac00091a007
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
