The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
LC/MS/MS of carbohydrates with postcolumn addition of metal chlorides using triaxial electrospray probe
Abstract
A new technique for on-line postcolumn addition (PCA) formation and tandem electrospray mass spectrometry of carbohydrate-metal complexes is presented. A metal chloride solution is added to a carbohydrate sample directly within the ion source of the mass spectrometer. Using a triaxial electrospray probe, this technique can be applied to form carbohydrate-metal complexes on-line, without the need of previously mixing the carbohydrate and metal chloride. Two basic tasks may be accomplished: structural analysis and sensitivity enhancement. The performance of this approach is demonstrated through PCA of LiCl, NaCl, KCl, RbCl, CsCl, and CoCl2, introduced via the triaxial probe after chromatographic separation of two four-component carbohydrate mixtures. Each metal-carbohydrate complex is subsequently analyzed by on-line MS and MS/MS. This technique is used to enhance sensitivity and also, in the case of cobalt coordination, to assist in carbohydrate structural elucidation. On-line LC/MS with PCA of LiCl was achieved with as little as 1.7 pmol of oligosaccharide (average consumed amount, 1.7 pmol with 1 microL of a 10 pmol/microL carbohydrate test mixture injection).
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“Online Post-column complex formation by addition of metal binding partner has been used, to study carbohydrates67 and siderophores68, respectively, which we here expand to protein targets as binding partners.”
From Native metabolomics identifies the rivulariapeptolide family of protease inhibitors (2022) · cites this paper as [67]
Citations
Cites
Improved electrospray ionization interface for capillary zone electrophoresis-mass spectrometry
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Self-citationCarr, S. A., Huddleston, M. J., & Bean, M. F. (1993) · Protein Science · doi:10.1002/pro.5560020207 · Cited by 285
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Self-citationFura, A., & Leary, J. A. (1993) · Analytical Chemistry · doi:10.1021/ac00068a017 · Cited by 116
Self-citationCharacterization of N-linked oligosaccharides by electrospray and tandem mass spectrometry
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Structural analysis of proteins by capillary HPLC electrospray tandem mass spectrometry
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Cited by
Sorted by citations
Mass spectrometry of oligosaccharides
Zaia, J. (2004) · Mass Spectrometry Reviews · doi:10.1002/mas.10073 · Cited by 802
GAO, S., Zhang, Z., & Karnes, H. T. (2005) · Journal of Chromatography B · doi:10.1016/j.jchromb.2005.04.021 · Cited by 230
Application of Fourier transform ion cyclotron resonance mass spectrometry to oligosaccharides
Park, Y., & Lebrilla, C. B. (2004) · Mass Spectrometry Reviews · doi:10.1002/mas.20010 · Cited by 149
Determination of steroids by liquid chromatography/mass spectrometry
Ma, Y., & Kim, H. (1997) · Journal of the American Society for Mass Spectrometry · doi:10.1016/s1044-0305(97)00122-0 · Cited by 147
Adamson, J. T., & Håkansson, K. (2007) · Analytical Chemistry · doi:10.1021/ac0621423 · Cited by 132
Metadata
- Authors
- Kohler, M., & Leary, J. A.
- Affiliations
- University of California, Berkeley (US)
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1995-10-01
- Volume
- 67
- Issue
- 19
- Pages
- 3501-3508
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2091422516
- Cited by
- 96
- References
- 21
- Citations by year
- 2025: 2 · 2023: 3 · 2022: 3 · 2019: 2 · 2018: 5 · 2016: 1 · 2015: 4 · 2014: 1 · 2013: 3 · 2012: 2
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Analytical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (GM-47356, R01GM047356)
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Mass Spectrometry Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical Chemistry and Chromatography
- Keywords
- LC-MS/MS, metal chlorides, cobalt complexation, sensitivity enhancement
- MeSH terms
- Carbohydrates, Chlorides, Chromatography, Liquid, Metals, Mass Spectrometry
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