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Conjugation of Luminescent Quantum Dots with Antibodies Using an Engineered Adaptor Protein To Provide New Reagents for Fluoroimmunoassays
Abstract
We describe the preparation and characterization of bioinorganic conjugates made with highly luminescent semiconductor CdSe-ZnS core-shell quantum dots (QDs) and antibodies for use in fluoroimmunoassays. The conjugation strategy employs an engineered molecular adaptor protein, attached to the QDs via electrostatic/hydrophobic self-assembly, to link the inorganic fluorophore with antibodies. In this method, the number of antibodies conjugated to a single QD can be varied. In addition, we have developed a simple purification strategy based on mixed-composition conjugates of the molecular adaptor and a second two-domain protein that allows the use of affinity chromatography. QD-antibody conjugates were successfully used in fluoroimmunoassays for detection of both a protein toxin (staphylococcal enterotoxin B) and a small molecule (2,4,6-trinitrotoluene).
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Dabbousi, B. O., Rodriguez-Viejo, J., Mikulec, F. V., Heine, J. R., Mattoussi, H., Ober, R., Jensen, K. F., & Bawendi, M. G. (1997) · The Journal of Physical Chemistry B · doi:10.1021/jp971091y · Cited by 4,229
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In Vivo Imaging of Quantum Dots Encapsulated in Phospholipid Micelles
Dubertret, B., Skourides, P., Norris, D. J., Noireaux, V., Brivanlou, A. H., & Libchaber, A. (2002) · Science · doi:10.1126/science.1077194 · Cited by 3,019
Maxwell, T., Nogueira Campos, M. G., Smith, S., Doomra, M., Thwin, Z., & Santra, S. (2020) · Nanoparticles for Biomedical Applications · doi:10.1016/b978-0-12-816662-8.00015-1 · Cited by 43
Metadata
- Authors
- Goldman, E. R., Anderson, G. P., Tran, P. T., Mattoussi, H., Charles, P. T., & Mauro, J. M.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-01-03
- Volume
- 74
- Issue
- 4
- Pages
- 841-847
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2035527702
- Cited by
- 411
- References
- 1
- FWCI
- 18.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Goldman, E. R., Anderson, G. P., Tran, P. T., Mattoussi, H., Charles, P. T., & Mauro, J. M. (2002). Conjugation of Luminescent Quantum Dots with Antibodies Using an Engineered Adaptor Protein To Provide New Reagents for Fluoroimmunoassays. Analytical Chemistry. https://doi.org/10.1021/ac010662m
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