The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Spectroscopic Tags Using Dye-Embedded Nanoparticles and Surface-Enhanced Raman Scattering
Abstract
Surface-enhanced Raman scattering is capable of providing rich vibrational information at the level of single molecules and single nanoparticles, but the practical applications of this enormous enhancement effect are still a challenge. Here we report a new class of dye-embedded core-shell nanoparticles that are highly efficient for surface Raman enhancement and could be used as spectroscopic tags for multiplexed detection and spectroscopy. The core-shell particles contain a metallic core for optical enhancement, a reporter molecule for spectroscopic signature, and an encapsulating silica shell for protection and conjugation. A surprising finding is that organic molecules with an isothiocyanate (-N=C=S) group or multiple sulfur atoms are compatible with silica encapsulation. In comparison with fluorescent dyes and quantum dots, enhanced Raman probes contain a built-in mechanism for signal amplification and provide rich spectroscopic information under ambient experimental conditions.
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Cites
Fluidity of Bound Hydration Layers
Raviv, U., & Klein, J. (2002) · Science · doi:10.1126/science.1074481 · Cited by 721
Cited by
In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags
Qian, X., Peng, X.-H., Ansari, D. O., Yin-Goen, Q., Chen, G. Z., Shin, D. M., Yang, L., Young, A. N., Wang, M. D., & Nie, S. (2008) · Nature Biotechnology · doi:10.1038/nbt1377 · Cited by 2,201
Self-citationLocalized surface plasmon resonance: Nanostructures, bioassays and biosensing—A review
Petryayeva, E., & Krull, U. J. (2011) · Analytica Chimica Acta · doi:10.1016/j.aca.2011.08.020 · Cited by 1,379
Gold Nanomaterials at Work in Biomedicine
Yang, X., Yang, M., Pang, B., Vara, M., & Xia, Y. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00193 · Cited by 1,162
Ngo, H. T., Gandra, N., Fales, A. M., Taylor, S. M., & Vo-Dinh, T. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.01.073 · Cited by 135
Biscaglia, F., Quarta, S., Villano, G., Turato, C., Biasiolo, A., Litti, L., Ruzzene, M., Meneghetti, M., Pontisso, P., & Gobbo, M. (2019) · Materials Science and Engineering: C · doi:10.1016/j.msec.2019.109762 · Cited by 25
Metadata
- Authors
- Doering, W. E., & Nie, S.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2003-10-03
- Volume
- 75
- Issue
- 22
- Pages
- 6171-6176
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W1963913631
- Cited by
- 470
- References
- 1
- FWCI
- 11.83
- Type
- journal article
- Language
- en
- Open access
- closed
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