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Acetylcholinesterase-Based Organophosphate Nerve Agent Sensing Photonic Crystal
Abstract
We developed a polymerized crystalline colloidal array (PCCA) photonic crystal sensing material that senses the organophosphorus compound parathion at ultratrace concentrations in aqueous solutions. A periodic array of colloidal particles is embedded in a hydrogel network with a lattice spacing such that it Bragg diffracts visible light. The molecular recognition agent for the sensor is the enzyme acetylcholinesterase (AChE), which binds organophosphorus compounds irreversibly, creating an anionic phosphonyl species. This charged species creates a Donnan potential, which swells the hydrogel network, which increases the embedded particle array lattice spacing and causes a red-shift in the wavelength of light diffracted. The magnitude of the diffraction red-shift is proportional to the amount of bound parathion. These AChE-PCCAs act as dosimeters for parathion since it irreversibly binds. Parathion concentrations as low as 4.26 fM are easily detected.
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Cited by
Stimuli-responsive polymers and their applications
Wei, M., Gao, Y., Li, X., & Serpe, M. J. (2017) · Polymer Chemistry · doi:10.1039/c6py01585a · Cited by 1,298
Borisov, S. M., & Wolfbeis, O. S. (2008) · Chemical Reviews · doi:10.1021/cr068105t · Cited by 1,018
Recent Advances in the Development of Chromophore-Based Chemosensors for Nerve Agents and Phosgene
Chen, L., Wu, D., & Yoon, J. (2018) · ACS Sensors · doi:10.1021/acssensors.7b00816 · Cited by 285
A colloidoscope of colloid-based porous materials and their uses
Phillips, K. R., England, G. T., Sunny, S., Shirman, E., Shirman, T., Vogel, N., & Aizenberg, J. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00533g · Cited by 282
Photonic Crystals in Bioassays
Zhao, Y., Zhao, X., & Gu, Z. (2010) · Advanced Functional Materials · doi:10.1002/adfm.201000098 · Cited by 255
Metadata
- Authors
- Walker, J. P., & Asher, S. A.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-02-12
- Volume
- 77
- Issue
- 6
- Pages
- 1596-1600
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2105531761
- Cited by
- 162
- References
- 0
- FWCI
- 4.51
- Type
- journal article
- Language
- en
- Open access
- closed
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