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A Reproducible Surface-Enhanced Raman Spectroscopy Approach. Online SERS Measurements in a Segmented Microfluidic System
Abstract
The application of a liquid/liquid microsegmented flow for serial high-throughput microanalytical systems shows promising prospects for applications in clinical chemistry, pharmaceutical research, process diagnostics, and analytical chemistry. Microscopy and microspectral analytics offer powerful approaches for the analytical readout of droplet based assays. Within the generated segments, individuality and integrity are retained during the complete diagnostic process making the approach favored for analysis of individual microscaled objects like cells and microorganisms embedded in droplets. Here we report on the online application of surface-enhanced micro-Raman spectroscopy for the detection and quantization of analytes in a liquid/liquid segmented microfluidic system. Data acquisition was performed in microsegments down to a volume of 180 nl. With this approach, we overcome the well-known problem of adhesion of colloid/analyte conjugates to the optical windows of detection cuvettes, which causes the so-called "memory effect". The combination of the segmented microfluidic system with the highly sensitive SERS technique reaches in a reproducible quantification of analytes with the SERS technique.
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Cited by
SERS Nanoparticles in Medicine: From Label-Free Detection to Spectroscopic Tagging
Lane, L. A., Qian, X., & Nie, S. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00265 · Cited by 873
Fundamental understanding and applications of plasmon-enhanced Raman spectroscopy
Wang, X., Huang, S.-C., Hu, S., Yan, S., & Ren, B. (2020) · Nature Reviews Physics · doi:10.1038/s42254-020-0171-y · Cited by 689
Surface-enhanced Raman spectroscopy: a half-century historical perspective
Yi, J., You, E.-M., Hu, R., Wu, D.-Y., Liu, G.-K., Yang, Z.-L., Zhang, H., Gu, Y., Wang, Y.-H., Wang, X., et al. (2025) · Chemical Society Reviews · doi:10.1039/d4cs00883a · Cited by 382
Self-citationDeep-UV surface-enhanced Raman scattering
Dörfer, T., Schmitt, M., & Popp, J. (2007) · Journal of Raman Spectroscopy · doi:10.1002/jrs.1831 · Cited by 141
Self-citationBenz, C., Retzbach, H., Nagl, S., & Belder, D. (2013) · Lab on a Chip · doi:10.1039/c3lc00057e · Cited by 38
Metadata
- Authors
- Strehle, K. R., Cialla, D., Rösch, P., Henkel, T., Köhler, M., & Popp, J.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-01-20
- Volume
- 79
- Issue
- 4
- Pages
- 1542-1547
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2090668354
- Cited by
- 238
- References
- 0
- FWCI
- 9.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- Strehle, K. R., Cialla, D., Rösch, P., Henkel, T., Köhler, M., & Popp, J. (2007). A Reproducible Surface-Enhanced Raman Spectroscopy Approach. Online SERS Measurements in a Segmented Microfluidic System. Analytical Chemistry. https://doi.org/10.1021/ac0615246
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