The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Enrichment of Cancer Cells Using Aptamers Immobilized on a Microfluidic Channel
Open accessAbstract
This work describes the development and investigation of an aptamer modified microfluidic device that captures rare cells to achieve a rapid assay without pretreatment of cells. To accomplish this, aptamers are first immobilized on the surface of a poly(dimethylsiloxane) microchannel, followed by pumping a mixture of cells through the device. This process permits the use of optical microscopy to measure the cell-surface density from which we calculate the percentage of cells captured as a function of cell and aptamer concentration, flow velocity, and incubation time. This aptamer-based device was demonstrated to capture target cells with >97% purity and >80% efficiency. Since the cell capture assay is completed within minutes and requires no pretreatment of cells, the device promises to play a key role in the early detection and diagnosis of cancer where rare diseased cells can first be enriched and then captured for detection.
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Citations
Cites
Detection of Mutations in EGFR in Circulating Lung-Cancer Cells
Maheswaran, S., Sequist, L. V., Nagrath, S., Ulkus, L., Brannigan, B., Collura, C. V., Inserra, E., Diederichs, S., Iafrate, A. J., Bell, D. W., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0800668 · Cited by 1,617
Cited by
Isolation of circulating tumor cells using a microvortex-generating herringbone-chip
Stott, S. L., Hsu, C.-H., Tsukrov, D. I., Yu, M., Miyamoto, D. T., Waltman, B. A., Rothenberg, S. M., Shah, A. M., Smas, M. E., Korir, G. K., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012539107 · Cited by 1,634
Aptamers from Cell-Based Selection for Bioanalytical Applications
Tan, W., Donovan, M. J., & Jiang, J. (2013) · Chemical Reviews · doi:10.1021/cr300468w · Cited by 649
Self-citationAptamer-based targeted therapy
Zhu, G., & Chen, X. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.08.005 · Cited by 522
Aptamer−Nanoparticle Strip Biosensor for Sensitive Detection of Cancer Cells
Liu, G., Mao, X., Phillips, J. A., Xu, H., Tan, W., & Zeng, L. (2009) · Analytical Chemistry · doi:10.1021/ac901889s · Cited by 340
Self-citationMicrofluidic approaches for cancer cell detection, characterization, and separation
Chen, J., Li, J., & Sun, Y. (2012) · Lab on a Chip · doi:10.1039/c2lc21273k · Cited by 301
Metadata
- Authors
- Phillips, J. A., Xu, Y., Xia, Z., Fan, Z. H., & Tan, W.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-12-30
- Volume
- 81
- Issue
- 3
- Pages
- 1033-1039
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W1987561076
- Cited by
- 225
- References
- 1
- FWCI
- 9.81
- Type
- journal article
- Language
- en
- Open access
- green
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