The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.
Microfluidic approaches for cancer cell detection, characterization, and separation
Abstract
This article reviews the recent developments in microfluidic technologies for in vitro cancer diagnosis. We summarize the working principles and experimental results of key microfluidic platforms for cancer cell detection, characterization, and separation based on cell-affinity micro-chromatography, magnetic activated micro-sorting, and cellular biophysics (e.g., cell size and mechanical and electrical properties). We examine the advantages and limitations of each technique and discuss future research opportunities for improving device throughput and purity, and for enabling on-chip analysis of captured cancer cells.
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Cites
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The origins and the future of microfluidics
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Isolation of rare circulating tumour cells in cancer patients by microchip technology
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Stott, S. L., Hsu, C.-H., Tsukrov, D. I., Yu, M., Miyamoto, D. T., Waltman, B. A., Rothenberg, S. M., Shah, A. M., Smas, M. E., Korir, G. K., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012539107 · Cited by 1,634
Detection of Mutations in EGFR in Circulating Lung-Cancer Cells
Maheswaran, S., Sequist, L. V., Nagrath, S., Ulkus, L., Brannigan, B., Collura, C. V., Inserra, E., Diederichs, S., Iafrate, A. J., Bell, D. W., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0800668 · Cited by 1,617
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Label-free cell separation and sorting in microfluidic systems
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ELECTRICAL FORCES FOR MICROSCALE CELL MANIPULATION
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Cited by
Slanted spiral microfluidics for the ultra-fast, label-free isolation of circulating tumor cells
Warkiani, M. E., Guan, G., Luan, K. B., Lee, W. C., Bhagat, A. A. S., Kant Chaudhuri, P., Tan, D. S.-W., Lim, W. T., Lee, S. C., Chen, P. C. Y., et al. (2014) · Lab Chip · doi:10.1039/c3lc50617g · Cited by 573
Hydrodynamic mechanisms of cell and particle trapping in microfluidics
Karimi, A., Yazdi, S., & Ardekani, A. M. (2013) · Biomicrofluidics · doi:10.1063/1.4799787 · Cited by 384
Microfluidic platform for negative enrichment of circulating tumor cells
Sajay, B. N. G., Chang, C.-P., Ahmad, H., Khuntontong, P., Wong, C. C., Wang, Z., Puiu, P. D., Soo, R., & Rahman, A. R. A. (2014) · Biomedical Microdevices · doi:10.1007/s10544-014-9856-2 · Cited by 56
Isolation of circulating tumour cells by physical means in a microfluidic device: a review
Patil, P., Madhuprasad, M., Kumeria, T., Losic, D., & Kurkuri, M. (2015) · RSC Advances · doi:10.1039/c5ra16489c · Cited by 47
Microfluidic system for modelling 3D tumour invasion into surrounding stroma and drug screening
Du, Z., Mi, S., Yi, X., Xu, Y., & Sun, W. (2018) · Biofabrication · doi:10.1088/1758-5090/aac70c · Cited by 42
Metadata
- Authors
- Chen, J., Li, J., & Sun, Y.
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2012
- Volume
- 12
- Issue
- 10
- Pages
- 1753
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- OpenAlex
- W2028843745
- Cited by
- 301
- References
- 107
- FWCI
- 18.31
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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