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Colorimetric Assay for Lead Ions Based on the Leaching of Gold Nanoparticles

Chen, Yi-You, Chang, Huan-Tsung, Shiang, Yen-Chun, Hung, Yu-Lun, Chiang, Cheng-Kang, Huang, Chih-Ching·2009·Analytical Chemistry

Abstract

A colorimetric, label-free, and nonaggregation-based gold nanoparticles (Au NPs) probe has been developed for the detection of Pb(2+) in aqueous solution, based on the fact that Pb(2+) ions accelerate the leaching rate of Au NPs by thiosulfate (S(2)O(3)(2-)) and 2-mercaptoethanol (2-ME). Au NPs reacted with S(2)O(3)(2-) ions in solution to form Au(S(2)O(3))(2)(3-) complexes on the Au NP surfaces, leading to slight decreases in their surface plasmon resonance (SPR) absorption. Surface-assisted laser desorption/ionization time-of-flight ionization mass spectrometry (SALDI-TOF MS) data reveals the formation of Pb-Au alloys on the surfaces of the Au NPs in the presence of Pb(2+) ions and 2-ME. The formation of Pb-Au alloys accelerated the Au NPs rapidly dissolved into solution, leading to dramatic decreases in the SPR absorption. The 2-ME/S(2)O(3)(2-)-Au NP probe is highly sensitive (LOD = 0.5 nM) and selective (by at least 1000-fold over other metal ions) toward Pb(2+) ions, with a linear detection range (2.5 nM-10 muM) over nearly 4 orders of magnitude. The cost-effective probe allows rapid and simple determination of the concentrations of Pb(2+) ions in environmental samples (Montana soil and river), with results showing its great practicality for the detection of lead in real samples.

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Metadata

Authors
Chen, Y.-Y., Chang, H.-T., Shiang, Y.-C., Hung, Y.-L., Chiang, C.-K., & Huang, C.-C.
Venue
Analytical Chemistry
Published
2009-10-23
Volume
81
Issue
22
Pages
9433-9439
ISSN
  • 0003-2700 (ISSN-L)
  • 1520-6882
OpenAlex
W1979958534
Cited by
229
References
1
FWCI
8.38
Type
journal article
Language
en
Open access
closed

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