The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Identification, Quantification, and Relative Concentrations of Carotenoids and Their Metabolites in Human Milk and Serum
Abstract
Thirty-four carotenoids, including 13 geometrical isomers and eight metabolites, in breast milk and serum of three lactating mothers have been separated, identified, quantified, and compared by high-performance liquid chromatography (HPLC)-photodiode array (PDA) detection-mass spectrometry (MS). Among the metabolites were two oxidation products of lycopene and four of lutein/ zeaxanthin. In addition, two metabolites of lutein, formed as a result of dehydration of this dihydroxycarotenoid under acidic conditions similar to those of the stomach, have also been identified in plasma and breast milk. The oxidative metabolites of lycopene with a novel five-membered-ring end group have been identified as epimeric 2,6-cyclolycopene-1,5-diols by comparison of their HPLC-UV/visible-MS profiles with those of fully characterized (1H- and 13C-NMR spectroscopy) synthetic compounds. The HPLC procedures employed also detected vitamin A, two forms of vitamin E (gamma- and alpha-tocopherol), and two non-carotenoid food components, i.e., piperine and caffeine, in serum and breast milk.
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Citations
Cites
Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration
Seddon, J. M. (1994) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1994.03520180037032 · Cited by 993
Cited by
The Role of Oxidative Stress in the Pathogenesis of Age-Related Macular Degeneration
Beatty, S., Koh, H.-H., Phil, M., Henson, D., & Boulton, M. (2000) · Survey of Ophthalmology · doi:10.1016/s0039-6257(00)00140-5 · Cited by 2,051
Antioxidant and Prooxidant Properties of Carotenoids
Young, A. J., & Lowe, G. M. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.2149 · Cited by 822
B IOLOGIC M ECHANISMS OF THE P ROTECTIVE R OLE OF L UTEIN AND Z EAXANTHIN IN THE E YE
Krinsky, N. I., Landrum, J. T., & Bone, R. A. (2003) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.23.011702.073307 · Cited by 779
Maiani, G., Periago Castón, M. J., Catasta, G., Toti, E., Cambrodón, I. G., Bysted, A., Granado‐Lorencio, F., Olmedilla‐Alonso, B., Knuthsen, P., Valoti, M., et al. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800053 · Cited by 773
Carotenoids Affect Proliferation of Human Prostate Cancer Cells
Kotake-Nara, E., Miyashita, K., Nagao, A., Kushiro, M., Zhang, H., & Sugawara, T. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.12.3303 · Cited by 462
Metadata
- Authors
- Khachik, F., Spangler, C. J., Smith, J. C., Canfield, L. M., Steck, A., & Pfander, H.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1997-05-01
- Volume
- 69
- Issue
- 10
- Pages
- 1873-1881
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W1982105988
- Cited by
- 535
- References
- 1
- FWCI
- 10.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Identification, Quantification, and Relative Concentrations of Carotenoids and Their Metabolites in Human Milk and Serum. https://app.cochat.ai/papers/10.1021/ac961085i
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- Khachik, F., Spangler, C. J., Smith, J. C., Canfield, L. M., Steck, A., & Pfander, H. (1997). Identification, Quantification, and Relative Concentrations of Carotenoids and Their Metabolites in Human Milk and Serum. Analytical Chemistry. https://doi.org/10.1021/ac961085i
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