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A High-Throughput Screening Method for the Determination of Aqueous Drug Solubility Using Laser Nephelometry in Microtiter Plates
Abstract
The determination of aqueous solubility in a high-throughput screening environment is invaluable in the selection of the most promising potential drug candidates. We describe a fast method based on laser nephelometry that can determine the solubility of potential drug candidates (usually from combinatorial chemistry) supplied as dimethyl sulfoxide (DMSO) solutions in 96-well plates. In the sample, the percent DMSO is kept constant allowing direct comparison of results. The nephelometric method has been shown to produce results equivalent to those produced by an HPLC method and to be largely unaffected by colored solutions.
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Citations
Cited by
Physicochemical Profiling (Solubility, Permeability and Charge State)
Avdeef, A. (2001) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026013395100 · Cited by 587
Impact of solid state properties on developability assessment of drug candidates
Huang, L. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.10.007 · Cited by 438
Finger, S., Wiegand, C., Buschmann, H.-J., & Hipler, U.-C. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.04.080 · Cited by 36
Metadata
- Authors
- Bevan, C. D., & Lloyd, R. S.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2000-03-10
- Volume
- 72
- Issue
- 8
- Pages
- 1781-1787
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2083372859
- Cited by
- 345
- References
- 0
- FWCI
- 7.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A High-Throughput Screening Method for the Determination of Aqueous Drug Solubility Using Laser Nephelometry in Microtiter Plates. https://app.cochat.ai/papers/10.1021/ac9912247
- The paper
- Bevan, C. D., & Lloyd, R. S. (2000). A High-Throughput Screening Method for the Determination of Aqueous Drug Solubility Using Laser Nephelometry in Microtiter Plates. Analytical Chemistry. https://doi.org/10.1021/ac9912247
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
