Nanosensor-Driven Detection of Neuron-Derived Exosomal Aβ 42 with Graphene Electrolyte-Gated Transistor for Alzheimer’s Disease Diagnosis
Abstract
Blood-based tests have sparked tremendous attention in non-invasive early diagnosis of Alzheimer’s disease (AD), a most prevalent neurodegenerative malady worldwide. Despite significant progress in the methodologies for detecting AD core biomarkers such as Aβ 42 from serum/plasma, there remains cautious optimism going forward due to its controversial diagnostic value and disease relevance. Here, a graphene electrolyte-gated transistor biosensor is reported for the detection of serum neuron-derived exosomal Aβ 42 (NDE-Aβ 42 ), which is an emerging, compelling trove of blood biomarker for AD. Assisted by the antifouling strategy with the dual-blocking process, the noise against complex biological background was considerably reduced, forging an impressive sensitivity gain with a limit of detection of 447 ag/mL. An accurate detection of SH-SY5Y-derived exosomal Aβ 42 was also achieved with highly conformable enzyme-linked immunosorbent assay results. Importantly, the clinical analysis for 27 subjects revealed the immense diagnostic value of NDE-Aβ 42, which can outclass that of serum Aβ 42 . The developed electronic assay demonstrates, for the first time, nanosensor-driven NDE-Aβ 42 detection, which enables a reliable discrimination of AD patients from non-AD individuals and even the differential diagnosis between AD and vascular dementia patients, with an accuracy of 100% and a Youden index of 1. This NDE-Aβ 42 biosensor defines a robust approach for blood-based confident AD ascertain.
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Li and coworkers developed a graphene electrolyte-gated transistor biosensor for detecting serum neuron-derived exosomal Aβ42 (NDE-Aβ42).
“Li and coworkers developed a graphene electrolyte-gated transistor biosensor for detecting serum neuron-derived exosomal Aβ42 (NDE-Aβ42), a biomarker rapidly gaining recognition for its relevance in AD [237].”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [237]
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- Authors
- Li, J., Ni, W., Jin, D., Yu, Y., Xiao, M.-M., Zhang, Z.-Y., & Zhang, G.-J.
- Affiliations
- Hubei University of Chinese Medicine (CN)
- Key Laboratory for the Physics and Chemistry of Nanodevices and Center for Carbon-based Electronics, School of Electronics, Peking University, Beijing 100871, P. R. China
- School of Laboratory Medicine, Hubei University of Chinese Medicine, 16 Huangjia Lake West Road, Wuhan 430065, P. R. China
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2023-03-21
- Volume
- 95
- Issue
- 13
- Pages
- 5719-5728
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W4328048504
- Cited by
- 60
- References
- 41
- Citations by year
- 2026: 16 · 2025: 31 · 2024: 11 · 2023: 2
- FWCI
- 4.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Analytical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (21974035)
- Topics
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Physical Sciences › Chemical Engineering › Bioengineering › Analytical Chemistry and Sensors
- Keywords
- Alzheimer's disease diagnosis, amyloid-beta 42, electronic biosensors, blood-based biomarkers, serum biomarkers, SH-SY5Y cells, differential diagnosis of dementia
- MeSH terms
- Alzheimer Disease, Graphite, Humans, Neuroblastoma, Neurons, Peptide Fragments, Biomarkers, Amyloid beta-Peptides, tau Proteins
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