The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Ratiometric Fluorescent Probe for Lysosomal pH Measurement and Imaging in Living Cells Using Single-Wavelength Excitation
Abstract
A novel lysosome-targeting ratiometric fluorescent probe (CQ-Lyso) based on the chromenoquinoline chromorphore has been developed for the selective and sensitive detection of intracellular pH in living cells. In acidic media, the protonation of the quinoline ring of CQ-Lyso induces an enhanced intramolecular charge transfer (ICT) process, which results in large red-shifts in both the absorption (104 nm) and emission (53 nm) spectra which forms the basis of a new ratiometric fluorescence pH sensor. This probe efficiently stains lysosomes with high Pearson's colocalization coefficients using LysoTrackerDeep Red (0.97) and LysoTrackerBlue DND-22 (0.95) as references. Importantly, we show that CQ-Lyso quantitatively measures and images lysosomal pH values in a ratiometric manner using single-wavelength excitation.
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Citations
Cites
(1999) · Choice Reviews Online · doi:10.5860/choice.37-0940 · Cited by 14,314
Lysosomal acidification mechanisms
Mindell, J. A. (2012) · Annual Review of Physiology · doi:10.1146/annurev-physiol-012110-142317 · Cited by 1,258
The lysosome: from waste bag to potential therapeutic target
Appelqvist, H., Wäster, P., Kågedal, K., & Öllinger, K. (2013) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjt022 · Cited by 772
Cited by
Yin, J., Huang, L., Wu, L., Li, J., James, T. D., & Lin, W. (2021) · Chemical Society Reviews · doi:10.1039/d1cs00645b · Cited by 549
Metadata
- Authors
- Liu, X., Su, Y., Tian, H., Yang, L., Zhang, H., Song, X., & Foley, J. W.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-06-12
- Volume
- 89
- Issue
- 13
- Pages
- 7038-7045
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2617380759
- Cited by
- 167
- References
- 3
- FWCI
- 10.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Liu, X., Su, Y., Tian, H., Yang, L., Zhang, H., Song, X., & Foley, J. W. (2017). Ratiometric Fluorescent Probe for Lysosomal pH Measurement and Imaging in Living Cells Using Single-Wavelength Excitation. Analytical Chemistry. https://doi.org/10.1021/acs.analchem.7b00754
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