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Fe–N–C Single-Atom Nanozymes for the Intracellular Hydrogen Peroxide Detection
Abstract
Recently, in situ detection of hydrogen peroxide (H 2 O 2 ) generated from live cells have caused tremendous attention, because it is of great significance in the control of multiple biological processes. Herein, Fe–N–C single-atom nanozymes (Fe–N–C SAzymes) with intrinsic peroxidase-like activity were successfully prepared via high-temperature calcination using FeCl 2, glucose, and dicyandiamide as precursors. The Fe–N–C SAzymes with FeN x as active sites were similar to natural metalloproteases, which can specifically enhance the peroxidase-like activity rather than oxidase-like activity. Accordingly, owing to the excellent catalytic efficiency of the Fe–N–C SAzymes, colorimetric biosensing of H 2 O 2 in vitro was performed via a typical 3,3′,5,5′-tetramethylbenzidine induced an allochroic reaction, demonstrating the satisfactory specificity and sensitivity. With regard to the practical application, in situ detection of H 2 O 2 generated from the Hela cells by the Fe–N–C SAzymes was also performed, which can expand the applications of the newborn SAzymes.
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Intrinsic peroxidase-like activity of ferromagnetic nanoparticles
Gao, L., Zhuang, J., Nie, L., Zhang, J., Zhang, Y., Gu, N., Wang, T., Feng, J., Yang, D., Perrett, S., et al. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.260 · Cited by 7,483
Zhang, H., An, P., Zhou, W., Guan, B. Y., Zhang, P., Dong, J., & Lou, X. W. (. (2018) · Science Advances · doi:10.1126/sciadv.aao6657 · Cited by 584
Cited by
Metal‐Nitrogen‐Doped Carbon Materials as Highly Efficient Catalysts: Progress and Rational Design
Shi, Z., Yang, W., Gu, Y., Liao, T., & Sun, Z. (2020) · Advanced Science · doi:10.1002/advs.202001069 · Cited by 470
Immunomodulation‐Enhanced Nanozyme‐Based Tumor Catalytic Therapy
Xu, B., Cui, Y., Wang, W., Li, S., Lyu, C., Wang, S., Bao, W., Wang, H., Qin, M., Liu, Z., et al. (2020) · Advanced Materials · doi:10.1002/adma.202003563 · Cited by 404
Cao, F., Zhang, L., You, Y., Zheng, L., Ren, J., & Qu, X. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201912182 · Cited by 319
Zhang, S., Li, Y., Sun, S., Liu, L., Mu, X., Liu, S., Jiao, M., Chen, X., Chen, K., Ma, H., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32411-z · Cited by 280
Defect engineering in nanozymes
Wu, Y., Xu, W., Jiao, L., Tang, Y., Chen, Y., Gu, W., & Zhu, C. (2022) · Materials Today · doi:10.1016/j.mattod.2021.10.032 · Cited by 269
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Metadata
- Authors
- Jiao, L., Xu, W., Yan, H., Wu, Y., Liu, C., Du, D., Lin, Y., & Zhu, C.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-08-22
- Volume
- 91
- Issue
- 18
- Pages
- 11994-11999
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2969998628
- Cited by
- 364
- References
- 2
- FWCI
- 15.11
- Type
- journal article
- Language
- en
- Open access
- closed
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