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Cited by 20Microbial Natural Products and BiosynthesisBacterial Genetics and BiotechnologyIron Metabolism and Disorders

Siderophores: A Case Study in Translational Chemical Biology

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LeBlanc, Andrew R., Wuest, William M.·2024·Biochemistry
DOI 10.1021/acs.biochem.4c00276PMC PMC11308372
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Abstract

Siderophores are metal-binding secondary metabolites that assist in iron homeostasis and have been of interest to the scientific community for the last half century. Foundational siderophore research has enabled several translational applications including siderophore-antibiotic and siderophore-peptide conjugates, identification of new antimicrobial targets, advances in disease imaging, and novel therapeutics. This review aims to connect the basic science research (biosynthesis, cellular uptake, gene regulation, and effects on homeostasis) of well-known siderophores with the successive translational application that results. Intertwined throughout are connections to the career of Christopher T. Walsh, his impact on the field of chemical biology, and the legacy of his trainees who continue to innovate.

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  • Iron is redox active and very poorly soluble in the oxidized Fe3+ form, which has led to the evolution of high affinity iron-binding siderophores synthesized by many bacteria and fungi.

    “Iron is redox active, and very poorly soluble in the oxidized Fe3+ (ferric) form, which has led to the evolution of high affinity iron-binding compounds (siderophores) synthesized by many bacteria and fungi.18,19”

    From Metals in Motion: Understanding Labile Metal Pools in Bacteria (2025) · cites this paper as [18]

    The Introduction (page unavailable) says iron hydrate Fe(OH)3 is highly insoluble at physiological pH and that bacteria evolved high-affinity siderophores that increase iron’s water solubility. The passages do not establish the claim’s extension to fungi or explicitly describe iron as redox active. (LLM, conf=0.86)

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Cited by

Sorted by citations

Authors
LeBlanc, A. R., & Wuest, W. M.
Affiliations
Emory University (US)
Corresponding author
Wuest, William M.
ORCID
Wuest, William M.
Venue
Biochemistry
Publisher
American Chemical Society (ACS)
Published
2024-07-23
Volume
63
Issue
15
Pages
1877-1891
ISSN
  • 0006-2960 (ISSN-L)
  • 1520-4995
DOI
10.1021/acs.biochem.4c00276
PMC
PMC11308372
OpenAlex
W4400914583
Cited by
20
References
5
Citations by year
2026: 9 · 2025: 11
FWCI
1.15
Type
journal article
Language
en
Open access
Licence
Locations
  • Biochemistry (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
National Institute of General Medical Sciences (GM119426)
Topics
  • Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords
siderophores, iron homeostasis, siderophore biosynthesis, siderophore uptake, gene expression regulation, siderophore-antibiotic conjugates, antimicrobial drug targets, chemical biology
MeSH terms
Animals, Anti-Bacterial Agents, Humans, Iron, Siderophores, Translational Research, Biomedical

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