A De Novo Designed Protein with Versatile Metal Binding and Tunable Hydrolytic Activity

Highly accurate protein structure prediction with AlphaFold

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Features and development of Coot

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<i>PHENIX</i> : a comprehensive Python-based system for macromolecular structure solution

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<i>Phaser</i> crystallographic software

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<i>XDS</i>

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Broadly applicable and accurate protein design by integrating structure prediction networks and diffusion generative models

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De novo design of protein structure and function with RFdiffusion

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Robust deep learning based protein sequence design using ProteinMPNN

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Robust deep learning–based protein sequence design using ProteinMPNN

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Copper Active Sites in Biology

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Program DYNAFIT for the Analysis of Enzyme Kinetic Data: Application to HIV Proteinase

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Metalloproteins and metal sensing

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ELECTRON TRANSFER IN PROTEINS

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Bayesian Deconvolution of Mass and Ion Mobility Spectra: From Binary Interactions to Polydisperse Ensembles

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Generalized biomolecular modeling and design with RoseTTAFold All-Atom

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Versatility of biological non-heme Fe(II) centers in oxygen activation reactions

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Short peptides self-assemble to produce catalytic amyloids

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Coordination polymers and molecular structures among complexes of mercury(II) halides with selected 1-benzoylthioureas

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Design and synthesis of multi-haem proteins

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Directed evolution of artificial metalloenzymes for in vivo metathesis

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Zinc enzymes

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Hydrolytic catalysis and structural stabilization in a designed metalloprotein

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Metal-directed, chemically tunable assembly of one-, two- and three-dimensional crystalline protein arrays

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De novo design of catalytic proteins

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Electron Flow through Metalloproteins

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Metal-Directed Protein Self-Assembly

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A designed supramolecular protein assembly with in vivo enzymatic activity

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Design of a heme-binding four-helix bundle

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Design and engineering of an O2 transport protein

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Computational design of serine hydrolases

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Ferredoxin and ferredoxin–heme maquettes

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Searching for harmony in transition-metal signaling

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Designing Hydrolytic Zinc Metalloenzymes

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Mechanistic Diversity in a Metalloenzyme Superfamily

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Zinc hydrolases: the mechanisms of zinc-dependent deacetylases

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Evolution of a highly active and enantiospecific metalloenzyme from short peptides

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De NovoDesign of Mercury-Binding Two- and Three-Helical Bundles

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Metal templated design of protein interfaces

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The Relationship between Intracellular Free Iron and Cell Injury in Cultured Neurons, Astrocytes, and Oligodendrocytes

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Elementary tetrahelical protein design for diverse oxidoreductase functions

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De novo metalloprotein design

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Constructing protein polyhedra via orthogonal chemical interactions

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Controlling Protein−Protein Interactions through Metal Coordination: Assembly of a 16-Helix Bundle Protein

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Designing a functional type 2 copper center that has nitrite reductase activity within α-helical coiled coils

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Construction and in vivo assembly of a catalytically proficient and hyperthermostable de novo enzyme

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Metal Binding Studies and EPR Spectroscopy of the Manganese Transport Regulator MntR

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Metal-Mediated Affinity and Orientation Specificity in a Computationally Designed Protein Homodimer

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E. coli surface display of streptavidin for directed evolution of an allylic deallylase

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A de novo peroxidase is also a promiscuous yet stereoselective carbene transferase

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Design and Construction of Functional Supramolecular Metalloprotein Assemblies

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All in the family: Structural and evolutionary relationships among three modular proteins with diverse functions and variable assembly

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A Whole Cell E. coli Display Platform for Artificial Metalloenzymes: Poly(phenylacetylene) Production with a Rhodium–Nitrobindin Metalloprotein

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Towards the Evolution of Artificial Metalloenzymes—A Protein Engineer's Perspective

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Control of Protein Oligomerization Symmetry by Metal Coordination: C2 and C3 Symmetrical Assemblies through CuII and NiII Coordination

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Tight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusion

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Evolution of Metal Selectivity in Templated Protein Interfaces

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A Superprotein Triangle Driven by Nickel(II) Coordination: Exploiting Non-Natural Metal Ligands in Protein Self-Assembly

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Computing the Role of Near Attack Conformations in an Enzyme-Catalyzed Nucleophilic Bimolecular Reaction

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Computational design of a homotrimeric metalloprotein with a trisbipyridyl core

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De Novo Design, Solution Characterization, and Crystallographic Structure of an Abiological Mn–Porphyrin-Binding Protein Capable of Stabilizing a Mn(V) Species

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Heteromeric three-stranded coiled coils designed using a Pb(ii)(Cys)3 template mediated strategy

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De Novo Design of an Allosteric Metalloprotein Assembly with Strained Disulfide Bonds

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β‐Hairpin Peptides: Heme Binding, Catalysis, and Structure in Detergent Micelles

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In Vitro and Cellular Self-Assembly of a Zn-Binding Protein Cryptand via Templated Disulfide Bonds

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Metal‐Templated Design of Chemically Switchable Protein Assemblies with High‐Affinity Coordination Sites

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A De Novo‐Designed Type 3 Copper Protein Tunes Catechol Substrate Recognition and Reactivity

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Controlled Protein Dimerization through Hybrid Coordination Motifs

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Atomically Accurate Design of Metalloproteins with Predefined Coordination Geometries

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Designed multi-stranded heme binding β-sheet peptides in membrane

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Targeted In Vivo Inhibition of Specific Protein–Protein Interactions Using Recombinant Antibodies

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Redox- and metal-directed structural diversification in designed metalloprotein assemblies

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Nature's Nanotech Warriors: The Role of Metalloproteins and Protein Cages for Environmental Remediation

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Computational Redesign of an Antifreeze Protein Using Deep LearningPreprint

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Coordination-site engineering in mononuclear non-heme metalloenzymes: From evolutionary motifs to programmable metal centers

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Designing Hydrolytic Zinc Metalloenzymes

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A tetrahedral zinc(II)-binding site introduced into a designed protein

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Metalloenzyme design and engineering through strategic modifications of native protein scaffolds

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A Tetrahedral Zinc ( 11)-Binding Site Introduced into a Designed Protein?

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Computational Design of Zinc Binding Sites at Protein Interfaces and Enzyme Active Sites

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