The DOI matches its Crossref record; 292 of the 292 references it cites were found in a registry or an index.
Use of Zebrafish in Drug Discovery Toxicology
Open accessAbstract
Unpredicted human safety events in clinical trials for new drugs are costly in terms of human health and money. The drug discovery industry attempts to minimize those events with diligent preclinical safety testing. Current standard practices are good at preventing toxic compounds from being tested in the clinic; however, false negative preclinical toxicity results are still a reality. Continual improvement must be pursued in the preclinical realm. Higher-quality therapies can be brought forward with more information about potential toxicities and associated mechanisms. The zebrafish model is a bridge between in vitro assays and mammalian in vivo studies. This model is powerful in its breadth of application and tractability for research. In the past two decades, our understanding of disease biology and drug toxicity has grown significantly owing to thousands of studies on this tiny vertebrate. This Review summarizes challenges and strengths of the model, discusses the 3Rs value that it can deliver, highlights translatable and untranslatable biology, and brings together reports from recent studies with zebrafish focusing on new drug discovery toxicology.
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Cites
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The zebrafish reference genome sequence and its relationship to the human genome.
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Self-citationSystems biology: a brief overview
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An analysis of the attrition of drug candidates from four major pharmaceutical companies
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Self-citationLessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework
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Cited by
A p21-GFP zebrafish model of senescence for rapid testing of senolytics in vivo
Morsli, S., Henriques, C. M., Ellis, P. S., Mortiboys, H., Baxendale, S., Loynes, C. A., Renshaw, S. A., & Bellantuono, I. (2023) · Aging Cell · doi:10.1111/acel.13835 · Cited by 21
Metadata
- Authors
- Cassar, S., Adatto, I., Freeman, J. L., Gamse, J. T., Iturria, I., Lawrence, C., Muriana, A., Peterson, R. T., Van Cruchten, S., & Zon, L. I.
- Venue
- Chemical Research in Toxicology
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-10-18
- Volume
- 33
- Issue
- 1
- Pages
- 95-118
- ISSN
- 0893-228X (ISSN-L)
- 1520-5010
- OpenAlex
- W2980676854
- Cited by
- 561
- References
- 292
- FWCI
- 23.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Cassar, S., Adatto, I., Freeman, J. L., Gamse, J. T., Iturria, I., Lawrence, C., Muriana, A., Peterson, R. T., Van Cruchten, S., & Zon, L. I. (2020). Use of Zebrafish in Drug Discovery Toxicology. Chemical Research in Toxicology. https://doi.org/10.1021/acs.chemrestox.9b00335
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
