The DOI matches its Crossref record; 224 of the 224 references it cites were found in a registry or an index.
A Journey from Structure to Function of Bacterial Lipopolysaccharides
Abstract
Lipopolysaccharide (LPS) is a crucial constituent of the outer membrane of most Gram-negative bacteria, playing a fundamental role in the protection of bacteria from environmental stress factors, in drug resistance, in pathogenesis, and in symbiosis. During the last decades, LPS has been thoroughly dissected, and massive information on this fascinating biomolecule is now available. In this Review, we will give the reader a third millennium update of the current knowledge of LPS with key information on the inherent peculiar carbohydrate chemistry due to often puzzling sugar residues that are uniquely found on it. Then, we will drive the reader through the complex and multifarious immunological outcomes that any given LPS can raise, which is strictly dependent on its chemical structure. Further, we will argue about issues that still remain unresolved and that would represent the immediate future of LPS research. It is critical to address these points to complete our notions on LPS chemistry, functions, and roles, in turn leading to innovative ways to manipulate the processes involving such a still controversial and intriguing biomolecule.
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Cites
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Cited by
Garcia-Vello, P., Tytgat, H. L. P., Elzinga, J., Van Hul, M., Plovier, H., Tiemblo-Martin, M., Cani, P. D., Nicolardi, S., Fragai, M., De Castro, C., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-52683-x · Cited by 74
Self-citation
Metadata
- Authors
- Di Lorenzo, F., Duda, K. A., Lanzetta, R., Silipo, A., De Castro, C., & Molinaro, A.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2021-07-21
- Volume
- 122
- Issue
- 20
- Pages
- 15767-15821
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W3185661542
- Cited by
- 322
- References
- 224
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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