The DOI matches its Crossref record; 180 of the 180 references it cites were found in a registry or an index.
HFIP in Organic Synthesis
Abstract
1,1,1,3,3,3-Hexafluoroisopropanol (HFIP) is a polar, strongly hydrogen bond-donating solvent that has found numerous uses in organic synthesis due to its ability to stabilize ionic species, transfer protons, and engage in a range of other intermolecular interactions. The use of this solvent has exponentially increased in the past decade and has become a solvent of choice in some areas, such as C-H functionalization chemistry. In this review, following a brief history of HFIP in organic synthesis and an overview of its physical properties, literature examples of organic reactions using HFIP as a solvent or an additive are presented, emphasizing the effect of solvent of each reaction.
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Cites
Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions
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An overview of N-heterocyclic carbenes
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Metadata
- Authors
- Motiwala, H. F., Armaly, A. M., Cacioppo, J. G., Coombs, T. C., Koehn, K. R. K., Norwood, V. M., & Aubé, J.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2022-07-17
- Volume
- 122
- Issue
- 15
- Pages
- 12544-12747
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W4285677181
- Cited by
- 593
- References
- 180
- FWCI
- 8.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- Motiwala, H. F., Armaly, A. M., Cacioppo, J. G., Coombs, T. C., Koehn, K. R. K., Norwood, V. M., & Aubé, J. (2022). HFIP in Organic Synthesis. Chemical Reviews. https://doi.org/10.1021/acs.chemrev.1c00749
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