The DOI matches its Crossref record; 116 of the 116 references it cites were found in a registry or an index.
Nitrogen-Centered Radicals in Functionalization of sp2 Systems: Generation, Reactivity, and Applications in Synthesis
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moieties without prefunctionalization, allowing for faster and more streamlined synthesis. This Review addresses the generation, reactivity, and application of NCRs, including, but not limited to, iminyl, aminyl, amidyl, and aminium species. Contributions from early discovery up to the most recent examples have been highlighted, covering radical initiation, thermolysis, photolysis, and, more recently, photoredox catalysis. Radical-mediated intermolecular amination of (hetero)arenes can occur with a variety of complex amine precursors, generating aniline derivatives, an important class of structures for drug discovery and development. Functionalization of olefins is achievable in high anti-Markovnikov regioselectivity and allows access to difunctionalized structures when the intermediate carbon radicals are trapped. Additionally, the reactivity of NCRs can be harnessed for the rapid construction of N-heterocycles such as pyrrolidines, phenanthridines, quinoxalines, and quinazolinones.
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Cited by
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Metadata
- Authors
- Pratley, C., Fenner, S., & Murphy, J. A.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2022-03-14
- Volume
- 122
- Issue
- 9
- Pages
- 8181-8260
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W4220815302
- Cited by
- 422
- References
- 116
- FWCI
- 4.85
- Type
- journal article
- Language
- en
- Open access
- hybrid
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