The DOI matches its Crossref record; 204 of the 204 references it cites were found in a registry or an index.
A Brief Introduction to Chemical Reaction Optimization
Open accessAbstract
From the start of a synthetic chemist's training, experiments are conducted based on recipes from textbooks and manuscripts that achieve clean reaction outcomes, allowing the scientist to develop practical skills and some chemical intuition. This procedure is often kept long into a researcher's career, as new recipes are developed based on similar reaction protocols, and intuition-guided deviations are conducted through learning from failed experiments. However, when attempting to understand chemical systems of interest, it has been shown that model-based, algorithm-based, and miniaturized high-throughput techniques outperform human chemical intuition and achieve reaction optimization in a much more time- and material-efficient manner; this is covered in detail in this paper. As many synthetic chemists are not exposed to these techniques in undergraduate teaching, this leads to a disproportionate number of scientists that wish to optimize their reactions but are unable to use these methodologies or are simply unaware of their existence. This review highlights the basics, and the cutting-edge, of modern chemical reaction optimization as well as its relation to process scale-up and can thereby serve as a reference for inspired scientists for each of these techniques, detailing several of their respective applications.
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Extended-Connectivity Fingerprints
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Metadata
- Authors
- Taylor, C. J., Pomberger, A., Felton, K. C., Grainger, R., Barecka, M., Chamberlain, T. W., Bourne, R. A., Johnson, C. N., & Lapkin, A. A.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2023-02-23
- Volume
- 123
- Issue
- 6
- Pages
- 3089-3126
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W4321611726
- Cited by
- 437
- References
- 204
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Taylor, C. J., Pomberger, A., Felton, K. C., Grainger, R., Barecka, M., Chamberlain, T. W., Bourne, R. A., Johnson, C. N., & Lapkin, A. A. (2023). A Brief Introduction to Chemical Reaction Optimization. Chemical Reviews. https://doi.org/10.1021/acs.chemrev.2c00798
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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