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Enzymatic Halogenation and Dehalogenation Reactions: Pervasive and Mechanistically Diverse
Open accessAbstract
Naturally produced halogenated compounds are ubiquitous across all domains of life where they perform a multitude of biological functions and adopt a diversity of chemical structures. Accordingly, a diverse collection of enzyme catalysts to install and remove halogens from organic scaffolds has evolved in nature. Accounting for the different chemical properties of the four halogen atoms (fluorine, chlorine, bromine, and iodine) and the diversity and chemical reactivity of their organic substrates, enzymes performing biosynthetic and degradative halogenation chemistry utilize numerous mechanistic strategies involving oxidation, reduction, and substitution. Biosynthetic halogenation reactions range from simple aromatic substitutions to stereoselective C-H functionalizations on remote carbon centers and can initiate the formation of simple to complex ring structures. Dehalogenating enzymes, on the other hand, are best known for removing halogen atoms from man-made organohalogens, yet also function naturally, albeit rarely, in metabolic pathways. This review details the scope and mechanism of nature's halogenation and dehalogenation enzymatic strategies, highlights gaps in our understanding, and posits where new advances in the field might arise in the near future.
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Bianco, A. C., Salvatore, D., Gereben, B., Berry, M. J., & Larsen, P. R. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.1.0455 · Cited by 1,853
RifamycinMode of Action, Resistance, and Biosynthesis
Floss, H. G., & Yu, T.-W. (2005) · Chemical Reviews · doi:10.1021/cr030112j · Cited by 547
Trimurtulu, G., Ohtani, I., Patterson, G. M. L., Moore, R. E., Corbett, T. H., Valeriote, F. A., & Demchik, L. (1994) · Journal of the American Chemical Society · doi:10.1021/ja00090a020 · Cited by 303
Messerschmidt, A., Prade, L., & Wever, R. (1997) · Biological Chemistry · doi:10.1515/bchm.1997.378.3-4.309 · Cited by 275
Mapping the reaction coordinates of enzymatic defluorination
Chan, P. W. Y., Yakunin, A. F., Edwards, E. A., & Pai, E. F. (2011) · Journal of the American Chemical Society · doi:10.1021/ja200277d · Cited by 107
Cited by
Carroll, A. R., Copp, B. R., Davis, R. A., Keyzers, R. A., & Prinsep, M. R. (2019) · Natural Product Reports · doi:10.1039/c8np00092a · Cited by 518
Wackett, L. P. (2022) · Microbial Biotechnology · doi:10.1111/1751-7915.13928 · Cited by 165
Halogenase engineering and its utility in medicinal chemistry
Fraley, A. E., & Sherman, D. H. (2018) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2018.04.066 · Cited by 45
Li, Y., Yue, Y., Zhang, H., Yang, Z., Wang, H., Tian, S., Wang, J.-B., Zhang, Q., & Wang, W. (2019) · Environment International · doi:10.1016/j.envint.2019.104999 · Cited by 33
Selective C−H Halogenation of Alkenes and Alkynes Using Flavin‐Dependent Halogenases
Jiang, Y., Kim, A., Olive, C., & Lewis, J. C. (2024) · Angewandte Chemie International Edition · doi:10.1002/anie.202317860 · Cited by 21
Metadata
- Authors
- Agarwal, V., Miles, Z. D., Winter, J. M., Eustáquio, A. S., El Gamal, A. A., & Moore, B. S.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-01-20
- Volume
- 117
- Issue
- 8
- Pages
- 5619-5674
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W2578925273
- Cited by
- 439
- References
- 5
- FWCI
- 3.07
- Type
- journal article
- Language
- en
- Open access
- green
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- Agarwal, V., Miles, Z. D., Winter, J. M., Eustáquio, A. S., El Gamal, A. A., & Moore, B. S. (2017). Enzymatic Halogenation and Dehalogenation Reactions: Pervasive and Mechanistically Diverse. Chemical Reviews. https://doi.org/10.1021/acs.chemrev.6b00571
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