RifamycinMode of Action, Resistance, and Biosynthesis

Structural Mechanism for Rifampicin Inhibition of Bacterial RNA Polymerase

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Detection of rifampicin-resistance mutations in Mycobacterium tuberculosis

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Molecular genetic basis of antimicrobial agent resistance inMycobacterium tuberculosis: 1998 update

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Crystal Structure of Thermus aquaticus Core RNA Polymerase at 3.3 Å Resolution

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Mapping and sequencing of mutations in the Escherichia colirpoB gene that lead to rifampicin resistance

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The specific inhibition of the DNA-directed RNA synthesis by rifamycin

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GELDANAMYCIN, A NEW ANTIBIOTIC

DeBoer, C., Meulman, P. A., Wnuk, R. J., & Peterson, D. H. (1970) · The Journal of Antibiotics · doi:10.7164/antibiotics.23.442 · Cited by 472 · see citing works

Evolution of Drug Resistance in Mycobacterium tuberculosis : Clinical and Molecular Perspective

Gillespie, S. H. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.2.267-274.2002 · Cited by 420 · see citing works

Rifampin: Mechanisms of Action and Resistance

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A Structural Model of Transcription Elongation

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Reconstitution of bacterial DNA‐dependent RNA‐polymerase from isolated subunits as a tool for the elucidation of the role of the subunits in transcription

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Mode of action of rifamycin on the RNA polymerase reaction

Sippel, A. E., & Hartmann, G. R. (1968) · Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis · doi:10.1016/0005-2787(68)90286-4 · Cited by 355 · see citing works

Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699

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History of the Development of Rifampin

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On the mechanism of rifampicin inhibition of RNA synthesis.

McClure, W. R., & Cech, C. L. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34269-2 · Cited by 315 · see citing works

Two New Genera of Nocardioform Actinomycetes: Amycolata gen. nov. and Amycolatopsis gen. nov.

Lechevalier, M. P., Prauser, H., Labeda, D. P., & Ruan, J. (1986) · International Journal of Systematic Bacteriology · doi:10.1099/00207713-36-1-29 · Cited by 312 · see citing works

Actions of the rifamycins

Wehrli, W., & STAEHELIN, M. (1971) · Bacteriological Reviews · doi:10.1128/br.35.3.290-309.1971 · Cited by 301 · see citing works

Probability Distribution of Drug-Resistant Mutants in Unselected Populations of Mycobacterium tuberculosis

David, H. L. (1970) · Applied Microbiology · doi:10.1128/am.20.5.810-814.1970 · Cited by 291 · see citing works

Rifampicin: A New Orally Active Rifamycin

Maggi, N., Pasqualucci, C. R., Ballotta, R., & Sensi, P. (2009) · Chemotherapia · doi:10.1159/000220462 · Cited by 270 · see citing works

Adverse Effects of Rifampin

Grosset, J. H. E., & Leventis, S. (1983) · Clinical Infectious Diseases · doi:10.1093/clinids/5.supplement_3.s440 · Cited by 224 · see citing works

Ansamitocin, a group of novel maytansinoid antibiotics with antitumour properties from Nocardia

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Characterization of In53, a Class 1 Plasmid- and Composite Transposon-Located Integron ofEscherichia coliWhich Carries an Unusual Array of Gene Cassettes

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Rifampicin region revisited. New rifampicin-resistant and streptolydigin-resistant mutants in the beta subunit of Escherichia coli RNA polymerase

Severinov, K. V., Soushko, M., Goldfarb, A., & Nikiforov, V. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82407-3 · Cited by 203 · see citing works

Molecular basis of rifampin resistance in Mycobacterium leprae

Honoré, N., & Cole, S. T. (1993) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.37.3.414 · Cited by 199 · see citing works

Rifampin and Rifabutin Resistance Mechanism in Helicobacter pylori

Heep, M., Beck, D., Bayerdörffer, E., & Lehn, N. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.6.1497 · Cited by 180 · see citing works

The Primary Structure of Escherichia coli RNA Polymerase

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Effect of Rifamycin on Protein Synthesis

Calvori, C., Frontali, L., LEONI, L., & Tecce, G. (1965) · Nature · doi:10.1038/207417a0 · Cited by 164 · see citing works

INHIBITION OF DNA-DEPENDENT RNA SYNTHESIS BY RIFAMYCINS

UMEZAWA, H., Mizuno, S., Yamazaki, H., & Nitta, K. (1968) · The Journal of Antibiotics · doi:10.7164/antibiotics.21.234 · Cited by 158 · see citing works

Animal DNA‐Dependent RNA Polymerases

Mellhac, M., Tyśper, Z., & Chambon, P. (1972) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1972.tb01913.x · Cited by 153 · see citing works

Mutations in the Beginning of the rpoB Gene Can Induce Resistance to Rifamycins in both Helicobacter pylori and Mycobacterium tuberculosis

Heep, M., Rieger, U., Beck, D., & Lehn, N. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.4.1075-1077.2000 · Cited by 153 · see citing works

The evolutionary role of secondary metabolites — a review

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A rifampicin resistent rna‐polymerase from E. coli altered in the β‐subunit

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Molecular Epidemiology of the Integron-Located VEB-1 Extended-Spectrum β-Lactamase in Nosocomial Enterobacterial Isolates in Bangkok, Thailand

Girlich, D., Poirel, L., Leelaporn, A., Karim, A., Tribuddharat, C., Fennewald, M., & Nordmann, P. (2001) · Journal of Clinical Microbiology · doi:10.1128/jcm.39.1.175-182.2001 · Cited by 141 · see citing works

Direct evidence that the rifamycin polyketide synthase assembles polyketide chains processively

Yu, T., Shen, Y., Doi-Katayama, Y., Tang, L., Park, C., Moore, B. S., Hutchinson, C. R., & Floss, H. G. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9051 · Cited by 136 · see citing works

Rifabutin

Brogden, R. N., & Fitton, A. (1994) · Drugs · doi:10.2165/00003495-199447060-00008 · Cited by 131 · see citing works

Ribosylative inactivation of rifampin by Mycobacterium smegmatis is a principal contributor to its low susceptibility to this antibiotic

Quan, S., Venter, H., & Dabbs, E. R. (1997) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.41.11.2456 · Cited by 123 · see citing works

Rifampicin Resistance of RNA Polymerase in the Binary Complex with DNA

Sippel, A. E., & Hartmann, G. R. (1970) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1970.tb01066.x · Cited by 119 · see citing works

Permeability Barrier to Rifampin in Mycobacteria

Hui, J., Gordon, N. C., & Kajioka, R. (1977) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.11.5.773 · Cited by 117 · see citing works

Natural products derived from unusual variants of the shikimate pathway

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3-Amino-5-hydroxybenzoic Acid Synthase, the Terminal Enzyme in the Formation of the Precursor of mC7N Units in Rifamycin and Related Antibiotics

Kim, C.-G., Yu, T., Fryhle, C. B., Handa, S., & Floss, H. G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.11.6030 · Cited by 111 · see citing works

Mutations affecting RNA Polymerase associated with Rifampicin Resistance in Escherichia coli

Ezekiel, D. H., & HUTCHINS, J. E. (1968) · Nature · doi:10.1038/220276a0 · Cited by 111 · see citing works

Ansamycins chemistry, biosynthesis and biological activity

Wehrli, W. (2006) · Topics in Current Chemistry · doi:10.1007/bfb0048448 · Cited by 110 · see citing works

The antibiotic rifampicin is a nonsteroidal ligand and activator of the human glucocorticoid receptor

Calleja, C., Pascussi, J., Mani, J. C., Maurel, P., & Vilarem, M. (1998) · Nature Medicine · doi:10.1038/nm0198-092 · Cited by 109 · see citing works

Active Transport of an Antibiotic Rifamycin Derivative by the Outer-Membrane Protein FhuA

Ferguson, A. D., Ködding, J., Walker, G., Bös, C., Coulton, J. W., Diederichs, K., Braun, V., & Welte, W. (2001) · Structure · doi:10.1016/s0969-2126(01)00631-1 · Cited by 109 · see citing works

RNA polymerase rifampicin resistance mutations in Escherichia coli: Sequence changes and dominance

Ovchinnikov, Y. A., MONASTYRSKAYA, G. S., Guriev, S. O., Nf, K., Sverdlov, E. D., Gragerov, A., Bass, I. A., Kiver, I. F., Moiseeva, E. P., Igumnov, V. N., et al. (1983) · Molecular and General Genetics MGG · doi:10.1007/bf00330662 · Cited by 107 · see citing works

Integron-Mediated Rifampin Resistance in Pseudomonas aeruginosa

Tribuddharat, C., & Fennewald, M. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.4.960 · Cited by 103 · see citing works

Ribosylation by mycobacterial strains as a new mechanism of rifampin inactivation

Dabbs, E. R., Yazawa, K., Mikami, Y., Miyaji, M., Morisaki, N., Iwasaki, S., & FURIHATA, K. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.4.1007 · Cited by 101 · see citing works

Cloning and sequence analysis of the putative rifamycin polyketide synthase gene cluster from Amycolatopsis mediterranei

Schupp, T., Toupet, C., Engel, N. K. V. D., & Goff, S. A. (1998) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1998.tb12861.x · Cited by 100 · see citing works

Cluster of genes in Escherichia coli for ribosomal proteins, ribosomal RNA, and RNA polymerase subunits.

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Mutational Analysis and Reconstituted Expression of the Biosynthetic Genes Involved in the Formation of 3-Amino-5-hydroxybenzoic Acid, the Starter Unit of Rifamycin Biosynthesis in Amycolatopsis mediterraneiS699

Yu, T., Müller, R., Müller, M., Zhang, X., Draeger, G., Kim, C.-G., Leistner, E. W., & Floss, H. G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009667200 · Cited by 93 · see citing works

Three New Antibiotic Producing Species of the Genus Amycolatopsis, Amycolatopsis balhimycina sp. nov., A. tolypomycina sp. nov., A. vancoresmycina sp. nov., and Description of Amycolatopsis keratiniphila subsp. keratiniphila subsp. nov. and A. keratiniphila subsp. nogabecina subsp. nov.

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Konstitution des Rifamycins B und verwandter Rifamycine

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Biosynthesis of 3-Amino-5-hydroxybenzoic Acid, the Precursor of mC7N Units in Ansamycin Antibiotics

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Engineered biosynthesis of an ansamycin polyketide precursor in Escherichia coli

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Characterization of the enzymatic domains in the modular polyketide synthase involved in rifamycin B biosynthesis by Amycolatopsis mediterranei

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Mutation to rifampicin resistance at the beginning of the RNA polymerase β subunit gene in Escherichia coli

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Action of rifamycin on RNA-polymerase from sensitive and resistant bacteria

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Ansamycine, eine neuartige Klasse von mikrobiellen Stoffwechselprodukten

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Molecular characterization of rifampin-resistant Neisseria meningitidis

CARTER, P. E., Abadi, F. J. R., Yakubu, D. E., & Pennington, T. H. (1994) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.38.6.1256 · Cited by 70 · see citing works

RifR mutations in the beginning of the Escherichia coli rpoB gene

Severinov, K., Soushko, M., Goldfarb, A., & Nikiforov, V. (1994) · Molecular and General Genetics MGG · doi:10.1007/bf00283512 · Cited by 68 · see citing works

Rifomycin. XI. taxonomic study on streptomyces mediterranei nov. sp.

Margalith, P., & BERETTA, G. (1960) · Mycopathologia · doi:10.1007/bf02089930 · Cited by 67 · see citing works

Rifampicin enhances anti-cancer drug accumulation and activity in multidrug-resistant cells

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Inactivation of rifampin by Nocardia brasiliensis

Yazawa, K., Mikami, Y., Maeda, A., Akao, M., Morisaki, N., & Iwasaki, S. (1993) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.37.6.1313 · Cited by 65 · see citing works

Characterization of Mutations in the rpoB Gene in Naturally Rifampin-Resistant Rickettsia Species

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Rifampin resistance in Neisseria meningitidis due to alterations in membrane permeability

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Rifampidn inhibition of RNA synthesis by destabilisation of DNA-RNA polymerase-oligonucleotide-complexes

Schulz, W. A., & Zillig, W. (1981) · Nucleic Acids Research · doi:10.1093/nar/9.24.6889 · Cited by 63 · see citing works

The Loading Module of Rifamycin Synthetase Is an Adenylation−Thiolation Didomain with Substrate Tolerance for Substituted Benzoates

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Kanosamine Biosynthesis: A Likely Source of the Aminoshikimate Pathway's Nitrogen Atom

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Über die Konstitution und die Konfiguration der Rifamycine B, O, S und SV

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The β Subunit Rif-cluster I Is Only Angstroms Away from the Active Center of Escherichia coli RNA Polymerase

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Topology of the RNA polymerase active center probed by chimeric rifampicin-nucleotide compounds.

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Rifamycins: an insight into biological activity based on structural investigations

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Active transport of siderophore-mimicking antibacterials across the outer membrane

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Mutations at Four Distinct Regions of the rpoB Gene Can Reduce the Susceptibility of Helicobacter pylori to Rifamycins

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Intermediates of rifamycin polyketide synthase produced by an Amycolatopsis mediterranei mutant with inactivated rifF gene

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The X-ray analysis of the structure of rifamycin B

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Characterization of the Early Stage Aminoshikimate Pathway in the Formation of 3-Amino-5-hydroxybenzoic Acid: The RifN Protein Specifically Converts Kanosamine into Kanosamine 6-Phosphate

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Current Topics in Microbiology and Immunology

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Different Rifampicin Inactivation Mechanisms in Nocardia and Related Taxa

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The organization and expression of essential transcription translation component genes in the extremely thermophilic eubacterium Thermotoga maritima

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A genetic approach to the biosynthesis of the Rifamycin-chromophore in Nocardia mediterranei. III. Isolation and identification of an early aromatic ansamycin-precursor containing the seven-carbon amino starter-unit and three initial acetate/propionate-units of the ansa chain.

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Phosphorylative inactivation of rifampicin by Nocardia otitidiscaviarum

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Thioesterases and the Premature Termination of Polyketide Chain Elongation in Rifamycin B Biosynthesis by Amycolatopsis mediterranei S699.

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Highly Efficient Uptake of a Rifamycin Derivative via the FhuA-TonB-dependent Uptake Route in Escherichia coli

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Primer Unit Specificity in Rifamycin Biosynthesis Principally Resides in the Later Stages of the Biosynthetic Pathway

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Early intermediates in the biosynthesis of ansamycins. I. Isolation and identification of protorifamycin I.

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ISOLATION OF RIFAMYCIN SV FROM A MUTANT STREPTOMYCES MEDITERRANEI STRAIN

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Rifomycin

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Sequence and analysis of the rpoB gene of Mycobacterium smegmatis

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A proposal for the transfer of Streptomyces mediterranei margalith and beretta 1960 to the genus Nocardia as Nocardia mediterranea (margalith and beretta) Comb. Nov.

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Biosynthesis of 1-Deoxy-1-imino- d -erythrose 4-Phosphate: A Defining Metabolite in the Aminoshikimate Pathway

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TOLYPOMYCIN, A NEW ANTIBIOTIC. III

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