The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Assessing Additivity of Cytotoxicity Associated with Disinfection Byproducts in Potable Reuse and Conventional Drinking Waters
Abstract
values to estimate the DBP-associated cytotoxicity of disinfected waters. This approach assumed that cytotoxicity was additive rather than synergistic or antagonistic. In this study, we evaluated whether this assumption was valid for mixtures containing DBPs at the concentration ratios measured in authentic disinfected waters. We examined the CHO cell cytotoxicity of defined DBP mixtures based on the concentrations of 43 regulated and unregulated DBPs measured in eight drinking and potable reuse waters. The hypothesis for additivity was supported using three experimental approaches. First, we demonstrated that the calculated additive toxicity (CAT) and bioassay-based calculated additive toxicity (BCAT) of the DBP mixtures agree within 12% on a median basis. We also found an additive toxicity response (CAT ≈ BCAT) between the regulated and unregulated DBP classes. Finally, the empirical biological cytotoxicity of the DBP subset mixtures, independent of the calculated toxicity, was additive. These results support the validity of using the sum of cytotoxic potency-weighted DBP concentrations as an estimate of the CHO cell cytotoxicity associated with known DBPs in real disinfected waters.
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RICHARDSON, S., PLEWA, M., WAGNER, E., SCHOENY, R., & DEMARINI, D. (2007) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2007.09.001 · Cited by 3,317
Self-citationOccurrence of a new generation of disinfection byproducts†
Krasner, S. W., Weinberg, H. S., Richardson, S. D., Pastor, S. J., Chinn, R., Sclimenti, M. J., Onstad, G. D., & Thruston, A. D. (2006) · Environmental Science & Technology · doi:10.1021/es060353j · Cited by 1,633
Li, X.-F., & Mitch, W. A. (2018) · Environmental Science & Technology · doi:10.1021/acs.est.7b05440 · Cited by 1,020
Self-citationOccurrence and Mammalian Cell Toxicity of Iodinated Disinfection Byproducts in Drinking Water
Richardson, S. D., Fasano, F., Ellington, J. J., Crumley, F. G., Buettner, K. M., Evans, J. J., Blount, B. C., Silva, L. K., Waite, T. J., Luther, G. W., et al. (2008) · Environmental Science & Technology · doi:10.1021/es801169k · Cited by 655
Self-citationGenotoxicity of water concentrates from recreational pools after various disinfection methods
Liviac, D., Wagner, E. D., Mitch, W. A., Altonji, M. J., & Plewa, M. J. (2010) · Environmental Science & Technology · doi:10.1021/es903593w · Cited by 121
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Cited by
Multiple Roles of Dissolved Organic Matter in Advanced Oxidation Processes
Yang, X., Rosario-Ortiz, F. L., Lei, Y., Pan, Y., Lei, X., & Westerhoff, P. (2022) · Environmental Science & Technology · doi:10.1021/acs.est.2c01017 · Cited by 459
Evaluation of Histidine Reactivity and Byproduct Formation During Peptide Chlorination
Choe, J. K., Hua, L.-C., Komaki, Y., Simpson, A. M.-A., McCurry, D. L., & Mitch, W. A. (2021) · Environmental Science & Technology · doi:10.1021/acs.est.0c07408 · Cited by 36
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Metadata
- Authors
- Lau, S. S., Wei, X., Bokenkamp, K., Wagner, E. D., Plewa, M. J., & Mitch, W. A.
- Venue
- Environmental Science & Technology
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-04-10
- Volume
- 54
- Issue
- 9
- Pages
- 5729-5736
- ISSN
- 0013-936X (ISSN-L)
- 1520-5851
- OpenAlex
- W3015513240
- Cited by
- 194
- References
- 5
- FWCI
- 8.94
- Type
- journal article
- Language
- en
- Open access
- closed
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