The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.
Pyrethroid Pesticides as Endocrine Disruptors: Molecular Mechanisms in Vertebrates with a Focus on Fishes
Abstract
Pyrethroids are now the fourth most used group of insecticides worldwide. Employed in agriculture and in urban areas, they are detected in waterways at concentrations that are lethally and sublethally toxic to aquatic organisms. Highly lipophilic, pyrethroids accumulate in sediments and bioaccumulate in fishes. Additionally, these compounds are demonstrated to act as endocrine disrupting compounds (or EDCs) in mammals and fishes, and therefore interfere with endocrine signaling by blocking, mimicking, or synergizing endogenous hormones through direct receptor interactions, and indirectly via upstream signaling pathways. Pyrethroid metabolites have greater endocrine activity than their parent structures, and this activity is dependent on the enantiomer present, as some pyrethroids are chiral. Many EDCs studied thus far in fish have known estrogenic or antiestrogenic effects, and as such cause the inappropriate or altered expression of genes or proteins (i.e., Vtg-vitellogenin, Chg-choriogenin), often leading to physiological or reproductive effects. Additionally, these compounds can also interfere with other endocrine pathways and immune response. This review highlights studies that focus on the mechanisms of pyrethroid biotransformation and endocrine toxicity to fishes across a broad range of different pyrethroid types, and integrates literature on the in vitro and mammalian responses that inform these mechanisms.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964
Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses
Vandenberg, L. N., Colborn, T., Hayes, T. B., Heindel, J. J., Jacobs, D. R., Lee, D.-H., Shioda, T., Soto, A. M., vom Saal, F. S., Welshons, W. V., et al. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1050 · Cited by 3,209
Collapse of a fish population after exposure to a synthetic estrogen
Kidd, K. A., Blanchfield, P. J., Mills, K. H., Palace, V. P., Evans, R. E., Lazorchak, J. M., & Flick, R. W. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609568104 · Cited by 2,094
Widespread Sexual Disruption in Wild Fish
Jobling, S., Nolan, M., Tyler, C. R., Brighty, G., & Sumpter, J. P. (1998) · Environmental Science & Technology · doi:10.1021/es9710870 · Cited by 2,002
Denison, M. S., & Nagy, S. R. (2003) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.135828 · Cited by 1,895
Effect of Endocrine Disruptor Pesticides: A Review
Mnif, W., Hassine, A. I. H., Bouaziz, A., Bartegi, A., Thomas, O., & Roig, B. (2011) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph8062265 · Cited by 1,012
Agricultural insecticides threaten surface waters at the global scale
Stehle, S., & Schulz, R. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1500232112 · Cited by 782
Pesticide Mixtures, Endocrine Disruption, and Amphibian Declines: Are We Underestimating the Impact?
Hayes, T. B., Case, P., Chui, S., Chung, D., Haeffele, C., Haston, K., Lee, M., Mai, V. P., Marjuoa, Y., Parker, J., et al. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.8051 · Cited by 644
Raun Andersen, H., Vinggaard, A. M., Høj Rasmussen, T., Gjermandsen, I. M., & Cecilie Bonefeld-Jørgensen, E. (2002) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2001.9347 · Cited by 603
Kojima, H., Katsura, E., Takeuchi, S., Niiyama, K., & Kobayashi, K. (2004) · Environmental Health Perspectives · doi:10.1289/ehp.6649 · Cited by 510
Cited by
Insight Into Microbial Applications for the Biodegradation of Pyrethroid Insecticides
Bhatt, P., Huang, Y., Zhan, H., & Chen, S. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01778 · Cited by 202
Siddiqui, S., Dickens, J. M., Cunningham, B. E., Hutton, S. J., Pedersen, E. I., Harper, B., Harper, S., & Brander, S. M. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.133934 · Cited by 77
Self-citationCrane, J. L. (2019) · Archives of Environmental Contamination and Toxicology · doi:10.1007/s00244-019-00598-w · Cited by 26
Metadata
- Authors
- Brander, S. M., Gabler, M. K., Fowler, N. L., Connon, R. E., & Schlenk, D.
- Venue
- Environmental Science & Technology
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-08-19
- Volume
- 50
- Issue
- 17
- Pages
- 8977-8992
- ISSN
- 0013-936X (ISSN-L)
- 1520-5851
- OpenAlex
- W2499059718
- Cited by
- 258
- References
- 105
- FWCI
- 11.13
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Pyrethroid Pesticides as Endocrine Disruptors: Molecular Mechanisms in Vertebrates with a Focus on Fishes. https://app.cochat.ai/papers/10.1021/acs.est.6b02253
- The paper
- Brander, S. M., Gabler, M. K., Fowler, N. L., Connon, R. E., & Schlenk, D. (2016). Pyrethroid Pesticides as Endocrine Disruptors: Molecular Mechanisms in Vertebrates with a Focus on Fishes. Environmental Science & Technology. https://doi.org/10.1021/acs.est.6b02253
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
