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Curcumin-Encapsulated Fusion Protein-Based Nanocarrier Demonstrated Highly Efficient Epidermal Growth Factor Receptor-Targeted Treatment of Colorectal Cancer
Abstract
Curcumin, a polyphenol derived from turmeric, has multiple biological functions, such as anti-inflammatory, antioxidant, antibacterial and, above all, antitumor activity. Colorectal cancer is a common malignancy of the gastrointestinal tract with an extremely high mortality rate. However, the low bioavailability and poor targeting properties of curcumin generally limit its clinical application. In the present study, we designed a fusion protein GE11-HGFI as a nanodrug delivery system. The protein was connected by flexible linkers, inheriting the self-assembly properties of hydrophobin HGFI and the targeting ability of GE11. The data show that the encapsulation of curcumin by fusion protein GE11-HGFI can form uniform and stable nanoparticles with a size of only 80 nm. In addition, the nanocarrier had high encapsulation efficiency for curcumin and made it to release sustainably. Notably, the drug-loaded nanosystem selectively targeted colorectal cancer cells with high epidermal growth factor receptor expression, resulting in high aggregated concentrations of curcumin at tumor sites, thus showing a significant anticancer effect. These results suggest that the nanocarrier fusion protein has the potential to be a novel strategy for enhancing molecular bioactivity and drug targeting in cancer therapy.
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Metadata
- Authors
- Han, Z., Song, B., Yang, J., Wang, B., Ma, Z., Yu, L., Li, Y., Xu, H., & Qiao, M.
- Affiliations
- Nankai University (CN)
- The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, P.R. China
- Remegen Co., Ltd., Shandong 264000, P.R. China
- Shanxi University (CN)
- Corresponding author
- Xu, Haijin
- Qiao, Mingqiang
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2022-12-01
- Volume
- 70
- Issue
- 49
- Pages
- 15464-15473
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W4310603289
- Semantic Scholar
- 45187cd97cb8a734187f126b7c50772599fbcf10
- Cited by
- 21
- References
- 54
- Citations by year
- 2026: 1 · 2025: 10 · 2024: 4 · 2023: 6
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Agricultural and Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Fund for Young Scholars of Tianjin (21JCQNJC00110)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
- Keywords
- curcumin, colorectal cancer, targeted drug delivery, self-assembly nanoparticles, sustained drug release, anticancer activity, bioavailability enhancement
- MeSH terms
- Antineoplastic Agents, Curcumin, Drug Carriers, Humans, Colorectal Neoplasms, Drug Delivery Systems, Nanoparticles, ErbB Receptors
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