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Dipeptidyl Peptidase IV Inhibitory Peptides Derived from Oat (Avena sativa L.), Buckwheat (Fagopyrum esculentum), and Highland Barley (Hordeum vulgare trifurcatum (L.) Trofim) Proteins
Abstract
Peptides released from oat, buckwheat, and highland barley proteins were examined for their in vitro inhibitory effects on dipeptidyl peptidase IV (DPP4), an enzyme that deactivates incretin hormones involved in insulin secretion. All of the hydrolysates exhibited DPP4 inhibitory activities, with IC50 values ranging from 0.13 mg/mL (oat glutelin alcalase digestion) to 8.15 mg/mL (highland barley albumin tryptic digestion). The lowest IC50 values in gastrointestinal, alcalase, and tryptic digestions were 0.99 mg/mL (oat flour), 0.13 mg/mL (oat glutelin), and 1.83 mg/mL (highland barley glutelin). In all, 35 peptides of more than seven residues were identified in the tryptic hydrolysates of oat globulin using liquid chromatography-mass spectroscopy. Peptides LQAFEPLR and EFLLAGNNK were synthesized and their DPP4 inhibitory activities determined. LQAFEPLR showed high in vitro DPP4 inhibitory activity with an IC50 value of 103.5 μM.
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Cited by
Martínez-Villaluenga, C., Peñas, E., & Hernández-Ledesma, B. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111178 · Cited by 325
Vilcacundo, R., Martínez-Villaluenga, C., & Hernández-Ledesma, B. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.06.024 · Cited by 264
Nutritional and functional perspectives of pseudocereals
Nandan, A., Koirala, P., Dutt Tripathi, A., Vikranta, U., Shah, K., Gupta, A. J., Agarwal, A., & Nirmal, N. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.139072 · Cited by 94
Metadata
- Authors
- Wang, F., Yu, G., Zhang, Y., Zhang, B., & Fan, J.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-10-22
- Volume
- 63
- Issue
- 43
- Pages
- 9543-9549
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2463467188
- Cited by
- 159
- References
- 0
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Dipeptidyl Peptidase IV Inhibitory Peptides Derived from Oat (Avena sativa L.), Buckwheat (Fagopyrum esculentum), and Highland Barley (Hordeum vulgare trifurcatum (L.) Trofim) Proteins. https://app.cochat.ai/papers/10.1021/acs.jafc.5b04016
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- Wang, F., Yu, G., Zhang, Y., Zhang, B., & Fan, J. (2015). Dipeptidyl Peptidase IV Inhibitory Peptides Derived from Oat (Avena sativa L.), Buckwheat (Fagopyrum esculentum), and Highland Barley (Hordeum vulgare trifurcatum (L.) Trofim) Proteins. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/acs.jafc.5b04016
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