Bifidobacterium bifidum Alleviate Intestinal Barrier Damage by Regulating the Intestinal Flora and Colonic Mucin O-Glycan Structural Patterns

High throughput ANI analysis of 90K prokaryotic genomes reveals clear species boundaries

Jain, C., Rodriguez-R, L. M., Phillippy, A. M., Konstantinidis, K. T., & Aluru, S. (2018) · Nature Communications · doi:10.1038/s41467-018-07641-9 · Cited by 5,748

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

Johansson, M. E. V., Gustafsson, J. K., Holmén-Larsson, J., Jabbar, K. S., Xia, L., Xu, H., Ghishan, F. K., Carvalho, F. A., Gewirtz, A. T., Sjövall, H., et al. (2014) · Gut · doi:10.1136/gutjnl-2012-303207 · Cited by 1,004

Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis

van der Post, S., Jabbar, K. S., Birchenough, G. M. H., Arike, L., Akhtar, N., Sjövall, H., Johansson, M., & Hansson, G. C. (2019) · Gut · doi:10.1136/gutjnl-2018-317571 · Cited by 550

Normalization of host intestinal mucus layers requires long-term microbial colonization

Johansson, M. E. V., Jakobsson, H. E., Holmén-Larsson, J., Schütte, A., Ermund, A., Rodríguez-Piñeiro, A. M., Arike, L., Wising, C., Svensson, F., Bäckhed, F., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.10.007 · Cited by 549

Endogenous murine microbiota member Faecalibaculum rodentium and its human homologue protect from intestinal tumour growth

Zagato, E., Pozzi, C., Bertocchi, A., Schioppa, T., Saccheri, F., Guglietta, S., Fosso, B., Melocchi, L., Nizzoli, G., Troisi, J., et al. (2020) · Nature Microbiology · doi:10.1038/s41564-019-0649-5 · Cited by 492

Inflammatory bowel disease in a Swedish twin cohort: a long-term follow-up of concordance and clinical characteristics

Halfvarson, J., Bodin, L., Tysk, C., Lindberg, E., & Järnerot, G. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00385-8 · Cited by 427

Loss of intestinal core 1–derived O-glycans causes spontaneous colitis in mice

Fu, J., Wei, B., Wen, T., Johansson, M. E. V., Liu, X., Bradford, E., Thomsson, K. A., McGee, S., Mansour, L., Tong, M., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45538 · Cited by 366

Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation

Larsson, J. M. H., Karlsson, H., Crespo, J. G., Johansson, M., Eklund, L., Sjövall, H., & Hansson, G. C. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21625 · Cited by 355

OmicStudio: A composable bioinformatics cloud platform with real‐time feedback that can generate high‐quality graphs for publication

Lyu, F., Han, F., Ge, C., Mao, W., Chen, L., Hu, H., Chen, G., Lang, Q., & Fang, C. (2023) · iMeta · doi:10.1002/imt2.85 · Cited by 354

Epithelial IL-22RA1-Mediated Fucosylation Promotes Intestinal Colonization Resistance to an Opportunistic Pathogen

Pham, T. A. N., Clare, S., Goulding, D., Arasteh, J. M., Stares, M., Browne, H. P., Keane, J. A., Page, A. J., Kumasaka, N., Kane, L., et al. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.08.017 · Cited by 324

Glycobiology simplified: diverse roles of glycan recognition in inflammation

Schnaar, R. L. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ri0116-021r · Cited by 146

Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis

Fuss, I. J., Heller, F., Boirivant, M., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419836 · Cited by 111

O-glycans truncation modulates gastric cancer cell signaling and transcription leading to a more aggressive phenotype

Freitas, D. P., Campos, D., Gomes, J., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.01.017 · Cited by 92

Nutritional strategies for mucosal health: the interplay between microbes and mucin glycans

Belzer, C. (2021) · Trends in Microbiology · doi:10.1016/j.tim.2021.06.003 · Cited by 78

Genetic strategies for mucin metabolism inBifidobacterium bifidumPRL2010: An example of possible human-microbe co-evolution

Turroni, F., Milani, C., van Sinderen, D., & Ventura, M. (2011) · Gut Microbes · doi:10.4161/gmic.2.3.16105 · Cited by 77

Bifidobacterium bifidum Extracellular Sialidase Enhances Adhesion to the Mucosal Surface and Supports Carbohydrate Assimilation

Nishiyama, K., Yamamoto, Y., Sugiyama, M., Takaki, T., Urashima, T., Fukiya, S., Yokota, A., Okada, N., & Mukai, T. (2017) · mBio · doi:10.1128/mbio.00928-17 · Cited by 77

Structural Characterization and Immunomodulatory Activity of a Mannose-Rich Polysaccharide Isolated from Bifidobacterium breve H4–2

Niu, M.-M., Guo, H.-X., Shang, J., et al. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c04916 · Cited by 69

Bifidobacterium animalis subsp. lactis XLTG11 improves antibiotic-related diarrhea by alleviating inflammation, enhancing intestinal barrier function and regulating intestinal flora

Xu, B., Liang, S., Zhao, J., Li, X., Guo, J., Xin, B., Li, B., Huo, G., & Ma, W. (2022) · Food & Function · doi:10.1039/d1fo04305f · Cited by 67

Distinct fucosylation of M cells and epithelial cells by Fut1 and Fut2, respectively, in response to intestinal environmental stress

Terahara, K., Nochi, T., Yoshida, M., Takahashi, Y., Goto, Y., Hatai, H., Kurokawa, S., Jang, M. H., Kweon, M.-N., Domino, S. E., et al. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.12.067 · Cited by 61

Exopolysaccharide Produced by Lactiplantibacillus plantarum-12 Alleviates Intestinal Inflammation and Colon Cancer Symptoms by Modulating the Gut Microbiome and Metabolites of C57BL/6 Mice Treated by Azoxymethane/Dextran Sulfate Sodium Salt

Ma, F., Song, Y., Sun, M., Wang, A., Jiang, S., Mu, G., & Tuo, Y. (2021) · Foods · doi:10.3390/foods10123060 · Cited by 59

POFUT1 promotes colorectal cancer development through the activation of Notch1 signaling

Du, Y., Li, D., Li, N., Chen, S., Yang, C., Lin, C., Chen, M., Wu, R., Li, X., & Hu, G. M. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1055-2 · Cited by 57

Notch Signaling in Mammalian Intestinal Stem Cells: Determining Cell Fate and Maintaining Homeostasis

Liang, S., Li, X., & Wang, X. (2019) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x14666190429143734 · Cited by 54

Dendrobium huoshanense polysaccharides ameliorate ulcerative colitis by improving intestinal mucosal barrier and regulating gut microbiota

Yu, J., Zhao, J., Xie, H., Cai, M., Yao, L., Li, J., Han, L., Chen, W., Yu, N., & Peng, D. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105231 · Cited by 52

Dextran sodium sulfate (DSS) induces necrotizing enterocolitis-like lesions in neonatal mice

Ginzel, M., Feng, X., Kuebler, J. F., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182732 · Cited by 49

Helicobacter suis binding to carbohydrates on human and porcine gastric mucins and glycolipids occurs via two modes

Padra, M., Adamczyk, B., Benktander, J. D., et al. (2018) · Virulence · doi:10.1080/21505594.2018.1460979 · Cited by 45

Behavioral abnormalities in C57BL/6 mice with chronic ulcerative colitis induced by DSS

Zhou, Y., Ji, G., Yang, X., Chen, Z., & Zhou, L. (2023) · BMC Gastroenterology · doi:10.1186/s12876-023-02718-2 · Cited by 35

Hydrogen-rich water partially alleviate inflammation, oxidative stress and intestinal flora dysbiosis in DSS-induced chronic ulcerative colitis mice

Song, L., Zhang, Y., Zhu, C., Ding, X., Yang, L., & Yan, H. (2021) · Advances in Medical Sciences · doi:10.1016/j.advms.2021.10.002 · Cited by 34

Bacterial and host fucosylation maintain IgA homeostasis to limit intestinal inflammation in mice

Lei, C., Luo, C., Xu, Z., Ding, S., Sriwastva, M. K., Dryden, G. W., Wang, T., Xu, M., Tan, Y. H., Wang, Q., et al. (2024) · Nature Microbiology · doi:10.1038/s41564-024-01873-w · Cited by 31

Sialylation in the gut: From mucosal protection to disease pathogenesis

Ma, X., Li, M., Wang, X., Qi, G., Wei, L., & Zhang, D. (2024) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2024.122471 · Cited by 29

Targeting epithelium-expressed sialyl Lewis glycans improves colonic mucosal wound healing and protects against colitis

Kelm, M., Quirós, M., Azcutia, V., Boerner, K., Cummings, R. D., Nusrat, A., Brazil, J. C., & Parkos, C. A. (2020) · JCI Insight · doi:10.1172/jci.insight.135843 · Cited by 28

Interactions between host and intestinal crypt-resided biofilms are controlled by epithelial fucosylation

Guo, X.-K., Wang, J., van Hensbergen, V. P., Liu, J., Xu, H., & Hu, X. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112754 · Cited by 28

Exopolysaccharides Produced by Bifidobacterium longum subsp. longum YS108R Ameliorates DSS-Induced Ulcerative Colitis in Mice by Improving the Gut Barrier and Regulating the Gut Microbiota

Li, H., Li, H., Stanton, C., Ross, R. P., Zhao, J., Chen, W., & Yang, B. K. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c06421 · Cited by 28

Chemotaxis-driven hybrid liposomes recover intestinal homeostasis for targeted colitis therapy

Pan, X., Xian, P., Li, Y., Zhao, X. K., Zhang, J., Song, Y., Nan, Y., Ni, S., & Hu, K. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.02.036 · Cited by 27

The role of glycosylated mucins in maintaining intestinal homeostasis and gut health

Cheng, H., Li, H., Li, Z., Yun, W., Liu, L., Wang, J., Ma, X., & Tan, B. (2025) · Animal nutrition · doi:10.1016/j.aninu.2025.03.004 · Cited by 27

Core Fucosylation of Intestinal Epithelial Cells Protects Against Salmonella Typhi Infection via Up-Regulating the Biological Antagonism of Intestinal Microbiota

Hao, S., Fan, Q., Bai, Y., Fang, H., Zhou, J., Fukuda, T., Gu, J., Li, M., & Li, W. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01097 · Cited by 26

Species- and Age/Generation-Dependent Adherence of Bifidobacterium bifidum to Human Intestinal Mucus In Vitro

Harata, G., Yoda, K., Wang, R., Miyazawa, K., Sato, M., He, F., & Endo, A. (2021) · Microorganisms · doi:10.3390/microorganisms9030542 · Cited by 26

Dietary nucleotides influences intestinal barrier function, immune responses and microbiota in 3-day-old weaned piglets

Liu, G., Liu, H., Tian, W., Liu, C., Yang, H., Wang, H., Gao, L., & Huang, Y. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109888 · Cited by 24

Antioxidant and Anti-Inflammatory Properties of Recombinant Bifidobacterium bifidum BGN4 Expressing Antioxidant Enzymes

Lin, Z., Ku, S., Lim, T., Park, S. Y., Park, M. S., Ji, G. E., O’Brien, K., & Hwang, K. T. (2021) · Microorganisms · doi:10.3390/microorganisms9030595 · Cited by 21

Tracker: continuous HMMER and BLAST searching

Marchin, M., Kelly, P. T., & Fang, J. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bti012 · Cited by 20

Revealing Glycosylation Patterns in In Vitro-Produced Mucus Exposed to Pasteurized Mucus-Associated Intestinal Microbes by MALDI-TOF-MS and PGC-LC-MS/MS

de Ram, C., van der Lugt, B., Elzinga, J., Geerlings, S. Y., Steegenga, W. T., Belzer, C., & Schols, H. A. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c01401 · Cited by 18

Hallmarks of glycogene expression and glycosylation pathways in squamous and adenocarcinoma cervical cancer

Martínez‐Morales, P., Cruz, I. M., la Cruz, L. R.-D., Maycotte, P., Salinas, J. S. R., Vazquez-Zamora, V. J., Quiroz, C. T. G., Montiel-Jarquín, Á. J., & Vallejo‐Ruiz, V. (2021) · PeerJ · doi:10.7717/peerj.12081 · Cited by 15

Intestinal epithelium-specific Fut2 deficiency promotes colorectal cancer through down-regulating fucosylation of MCAM

Wang, W., Tang, X., Duan, C., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-03906-0 · Cited by 15

Stress tolerance, safety, and probiotic traits of cholesterol-decreasing Bifidobacterium BLH1 isolated from Guizhou red sour soup, a traditional Chinese fermented food

Yang, H., Xiong, J., He, L., Li, C., Qiao, S., & Zeng, X. (2023) · LWT · doi:10.1016/j.lwt.2023.115696 · Cited by 15

Loss of core fucosylation suppressed the humoral immune response in Salmonella typhimurium infected mice

Zahid, D., Zhang, N., Fang, H., Gu, J., Li, M., & Li, W. (2020) · Journal of Microbiology Immunology and Infection · doi:10.1016/j.jmii.2020.02.006 · Cited by 13

Immune and microRNA responses toHelicobacter muridaruminfection and indole-3-carbinol during colitis

Alkarkoushi, R. R., Hui, Y. Y., Tavakoli, A. S., Singh, U. P., Nagarkatti, P. S., Nagarkatti, M., Chatzistamou, I., Bam, M., & Testerman, T. L. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i32.4763 · Cited by 13

Fermented Soymilk with Probiotic Lactobacilli and Bifidobacterium Strains Ameliorates Dextran-Sulfate-Sodium-Induced Colitis in Rats

Zahrani, A. J. A., Shori, A. B., & Al-Judaibi, E. A. (2024) · Nutrients · doi:10.3390/nu16203478 · Cited by 13

A westernized diet changed the colonic bacterial composition and metabolite concentration in a dextran sulfate sodium pig model for ulcerative colitis

Panah, F. M., Nielsen, K. D., Simpson, G. L., Schönherz, A. A., Schramm, A., Lauridsen, C., Nielsen, T. S., Højberg, O., Fredborg, M., Purup, S., et al. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1018242 · Cited by 9

Lactobacillus plantarum ZJUIDS04 alleviates DSS-induced colitis via modulating gut microbiota

Yu, C., Liu, J., Liu, Z., Ding, Q., Zhu, Q., Chen, N., Fu, J., Valencak, T. G., & Ren, D. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105794 · Cited by 8

A mannose-rich exopolysaccharide-1 isolated from Bifidobacterium breve mitigates ovalbumin-induced intestinal damage in mice by modulation CD4 + T cell differentiation and inhibiting NF-κB signaling pathway

Niu, M., Li, Y., Su, Q., Chen, S., Li, Q.-H., Guo, H.-X., Xiang-chen, M., & Liu, F. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.135850 · Cited by 5

Activation of notch signaling pathway is a potential mechanism for mucin2 reduction and intestinal mucosal barrier dysfunction in high-altitude hypoxia

Jia, R., Han, Y., Zhu, Q., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-96176-3 · Cited by 5

Androgens suppress the sialyltransferases ST3GAL1 and ST3GAL4 and modulate mucin 10 glycosylation in the submandibular gland, related to sex differences in commensal microbiota composition in mice

Deminami, M., Hashimoto, M., Takahashi, H., Harada, N., Minami, Y., Kitakaze, T., Masuda, W., Takenaka, S., Inui, H., & Yamaji, R. (2024) · Bioscience Biotechnology and Biochemistry · doi:10.1093/bbb/zbae175 · Cited by 4

Bifidobacterium bifidum FL-228.1 enhances mucus barrier via succinic acid-mediated PI3K-Akt/MUC2 signaling pathway in vitro

Wang, G., Ye, J., Du, W., Li, Y., Wang, Y., Yi, H., Zhang, L., & Liu, T. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.107645 · Cited by 3

Tu1777 Bifidobacterium Species Reduce Lipopolysaccharide-Induced Small Intestinal Epithelial Cell Shedding In Vivo in a MYD88-Dependent Manner and Protect Against DSS-Induced Colitis

Hughes, K. R., Alcon-Giner, C., VanSinderen, D., et al. (2014) · Gastroenterology · doi:10.1016/s0016-5085(14)63053-5 · Cited by 1

Effect of bifidobacterial adhesin on intestinal microflora and bacterial translocation induced by ischemia-reperfusion injury in rats

Zhong, S.-S. (2014) · World Chinese Journal of Digestology · doi:10.11569/wcjd.v22.i24.3632 · Cited by 1

Mo1812 ENGINEERED PROPIONATE-PRODUCING BACTERIA ATTENUATES MURINE COLITIS BY MODULATING THE IMMUNE FUNCTION OF RESIDENT MACROPHAGES AND ENHANCING MUCUS BARRIER

Wang, X., Feng, Z., Cao, X., et al. (2023) · Gastroenterology · doi:10.1016/s0016-5085(23)03122-0 · Cited by 1

Significance of Sulfated Glycans on Mucins in the Gut

Abo, H., & Kawashima, H. (2023) · Trends in Glycoscience and Glycotechnology · doi:10.4052/tigg.2219.1e · Cited by 1

Genome-scale insights into the metabolic landscape and evolutionary development of Bifidobacterium bifidum

Selleri, E., Longhi, G., Tarracchini, C., Carolis, E. D., Petraro, S., Mancabelli, L., Milani, C., Turroni, F., Ventura, M., & Lugli, G. A. (2026) · Microbiome Research Reports · doi:10.20517/mrr.2026.19