Loss of intestinal core 1–derived O-glycans causes spontaneous colitis in mice

Pathogen Recognition and Innate Immunity

Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 11,974 · see citing works

ASSEMBLY OF ASPARAGINE-LINKED OLIGOSACCHARIDES

Kornfeld, R., & Kornfeld, S. A. (1985) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.54.070185.003215 · Cited by 4,863 · see citing works

Unravelling the pathogenesis of inflammatory bowel disease

Xavier, R. J., & Podolsky, D. K. (2007) · Nature · doi:10.1038/nature06005 · Cited by 4,364 · see citing works

Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis

Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251 · see citing works

RAG-1-deficient mice have no mature B and T lymphocytes

Mombaerts, P., Iacomini, J., Johnson, R. S., Herrup, K., Tonegawa, S., & Papaioannou, V. E. (1992) · Cell · doi:10.1016/0092-8674(92)90030-g · Cited by 2,898 · see citing works

Inflammatory bowel disease

Abraham, C., & Cho, J. H. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804647 · Cited by 2,712 · see citing works

Essentials of Glycobiology

Varki, A. P., Cummings, R. D., Esko, J. D., Freeze, H. H., Stanley, P., Bertozzi, C. R., Hart, G. W., & Etzler, M. E. (1999) · Cited by 2,384 · see citing works

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

Johansson, M. E. V., Phillipson, M., Petersson, J., Velcich, A., Holm, L., & Hansson, G. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803124105 · Cited by 2,200 · see citing works

Muc2-Deficient Mice Spontaneously Develop Colitis, Indicating That MUC2 Is Critical for Colonic Protection

Van der Sluis, M., De Koning, B. A. E., De Bruijn, A. C. J. M., Velcich, A., Meijerink, J. P. P., Van Goudoever, J. B., Büller, H. A., Dekker, J., Van Seuningen, I., Renes, I. B., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.04.020 · Cited by 1,684 · see citing works

The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host–microbial interactions

Johansson, M., Larsson, J. M. H., & Hansson, G. C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006451107 · Cited by 1,459 · see citing works

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

Kaser, A., Lee, A., Franke, A., Glickman, J. N., Zeißig, S., Tilg, H., Nieuwenhuis, E. E. S., Higgins, D. E., Schreiber, S., Glimcher, L. H., et al. (2008) · Cell · doi:10.1016/j.cell.2008.07.021 · Cited by 1,411 · see citing works

The fundamental basis of inflammatory bowel disease

Strober, W., Fuss, I. J., & Mannon, P. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30587 · Cited by 1,310 · see citing works

The Immunology of Mucosal Models of Inflammation

Strober, W., Fuss, I. J., & Blumberg, R. S. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064816 · Cited by 1,300 · see citing works

Tissue‐specific and inducible Cre‐mediated recombination in the gut epithelium

Marjou, F. E., Janssen, K., Chang, B. H., Li, M., Hindie, V., Chan, L., Louvard, D., Chambon, P., METZGER, D., & Robine, S. (2004) · genesis · doi:10.1002/gene.20042 · Cited by 1,044 · see citing works

Mucosal Glycan Foraging Enhances Fitness and Transmission of a Saccharolytic Human Gut Bacterial Symbiont

Martens, E. C., Chiang, H. C., & Gordon, J. I. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.09.007 · Cited by 919 · see citing works

Communicable Ulcerative Colitis Induced by T-bet Deficiency in the Innate Immune System

Garrett, W. S., Lord, G. M., Punit, S., Lugo‐Villarino, G., Mazmanian, S. K., Ito, S., Glickman, J. N., & Glimcher, L. H. (2007) · Cell · doi:10.1016/j.cell.2007.08.017 · Cited by 918 · see citing works

Homeostasis and Inflammation in the Intestine

Garrett, W. S., Gordon, J. I., & Glimcher, L. H. (2010) · Cell · doi:10.1016/j.cell.2010.01.023 · Cited by 784 · see citing works

cis Elements of the Villin Gene Control Expression in Restricted Domains of the Vertical (Crypt) and Horizontal (Duodenum, Cecum) Axes of the Intestine

Madison, B., Dunbar, L., Qiao, X. T., Braunstein, K., Braunstein, E. M., & Gumucio, D. L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204935200 · Cited by 748 · see citing works

Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis

Heazlewood, C. K., Cook, M. C., Eri, R., Price, G. R., Tauro, S. B., Taupin, D., Thornton, D. J., Png, C. W., Crockford, T. L., Cornall, R. J., et al. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050054 · Cited by 701 · see citing works

Muc2 Protects against Lethal Infectious Colitis by Disassociating Pathogenic and Commensal Bacteria from the Colonic Mucosa

Bergstrom, K. S. B., Kissoon-Singh, V., Gibson, D. L., Ma, C., Montero, M., Sham, H. P., Ryz, N., Huang, T., Velcich, A., Finlay, B. B., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000902 · Cited by 625 · see citing works

Mucin‐type O‐glycans in human colon and breast cancer: glycodynamics and functions

Brockhausen, I. (2006) · EMBO Reports · doi:10.1038/sj.embor.7400705 · Cited by 512 · see citing works

Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis

Zaph, C., Troy, A. E., Taylor, B. C., Berman-Booty, L. D., Guild, K. J., Du, Y., Yost, E. A., Gruber, A. D., May, M. J., Greten, F. R., et al. (2007) · Nature · doi:10.1038/nature05590 · Cited by 496 · see citing works

A unique molecular chaperone Cosmc required for activity of the mammalian core 1 β3-galactosyltransferase

Ju, T., & Cummings, R. D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.262438199 · Cited by 489 · see citing works

Caveolin-1–dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo

Marchiando, A. M., Shen, L., Graham, W. V., Weber, C. R., Schwarz, B. T., Austin, J. R., Raleigh, D. R., Guan, Y., Watson, A. J. M., Montrose, M. H., et al. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200902153 · Cited by 475 · see citing works

Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota

Elson, C. O., Cong, Y., McCracken, V. J., Dimmitt, R. A., Lorenz, R. G., & Weaver, C. T. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00291.x · Cited by 469 · see citing works

Molecular cloning of human intestinal mucin (MUC2) cDNA. Identification of the amino terminus and overall sequence similarity to prepro-von Willebrand factor.

Gum, J. R., Hicks, J. W., Toribara, N. W., Siddiki, B., & Kim, Y. S. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41965-x · Cited by 433 · see citing works

Adhesive Interactions of Leukocytes, Platelets, and the Vessel Wall during Hemostasis and Inflammation

McEver, R. P. (2001) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1616128 · Cited by 391 · see citing works

Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease

McGovern, D. P. B., Jones, M. R., Taylor, K. D., Marciante, K. D., Yan, X., Dubinsky, M. C., Ippoliti, A., Vasiliauskas, E. A., Berel, D., Derkowski, C. A., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq248 · Cited by 379 · see citing works

Bacteria Penetrate the Inner Mucus Layer before Inflammation in the Dextran Sulfate Colitis Model

Johansson, M. E. V., Gustafsson, J. K., Sjöberg, K. E., Petersson, J., Holm, L., Sjövall, H., & Hansson, G. C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012238 · Cited by 368 · see citing works

Increased susceptibility to colitis and colorectal tumors in mice lacking core 3–derived O-glycans

An, G., Wei, B., Xia, B., McDaniel, J. M., Ju, T., Cummings, R. D., Braun, J., & Xia, L. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061929 · Cited by 352 · see citing works

Mucins in the gastrointestinal tract in health and disease

Anthony, P. P. (2001) · Frontiers in bioscience · doi:10.2741/corfield · Cited by 343 · see citing works

Mucins and inflammatory bowel disease

Shirazi, T. (2000) · Postgraduate Medical Journal · doi:10.1136/pmj.76.898.473 · Cited by 311 · see citing works

Mucin-type O-glycosylation and its potential use in drug and vaccine development

Tarp, M. A., & Clausen, H. (2007) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2007.09.010 · Cited by 303 · see citing works

A Nonsynonymous SNP in ATG16L1 Predisposes to Ileal Crohn’s Disease and Is Independent of CARD15 and IBD5

Prescott, N. J., Fisher, S. A., Franke, A., Hampe, J., Onnie, C. M., Soars, D., Bagnall, R. D., Mirza, M. M., Sanderson, J. D., Forbes, A., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.034 · Cited by 301 · see citing works

Human Tumor Antigens Tn and Sialyl Tn Arise from Mutations in Cosmc

Ju, T., Lanneau, G. S., Gautam, T., Wang, Y., Xia, B., Stowell, S. R., Willard, M. T., Wang, W., Xia, J. Y., Zuna, R. E., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2345 · Cited by 293 · see citing works

Cloning and Expression of Human Core 1 β1,3-Galactosyltransferase

Ju, T., Brewer, K., D’Souza, A., Cummings, R. D., & Canfield, W. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109060200 · Cited by 290 · see citing works

Chaperone mutation in Tn syndrome

Ju, T., & Cummings, R. D. (2005) · Nature · doi:10.1038/4371252a · Cited by 272 · see citing works

Methods for Monitoring Endoplasmic Reticulum Stress and the Unfolded Protein Response

Afshin Samali, A., FitzGerald, U., Deegan, S., & Gupta, S. (2010) · International Journal of Cell Biology · doi:10.1155/2010/830307 · Cited by 255 · see citing works

Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice

Fu, J., Gerhardt, H., McDaniel, J. M., Xia, B., Liu, X., Ivanciu, L., Ny, A., Hermans, K., Silasi‐Mansat, R., McGee, S., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36077 · Cited by 242 · see citing works

Mucin Gene Deficiency in Mice Impairs Host Resistance to an Enteric Parasitic Infection

Hasnain, S. Z., Wang, H., Ghia, J., Haq, N., Deng, Y., Velcich, A., Grencis, R. K., Thornton, D. J., & Khan, W. I. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.01.045 · Cited by 190 · see citing works

Defective angiogenesis and fatal embryonic hemorrhage in mice lacking core 1–derived O-glycans

Xia, L., Ju, T., Westmuckett, A. D., An, G., Ivanciu, L., McDaniel, J. M., Lupu, F., Cummings, R. D., & McEver, R. P. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200311112 · Cited by 186 · see citing works

P-Selectin Glycoprotein Ligand-1 Is Highly Expressed on Ly-6C hi Monocytes and a Major Determinant for Ly-6C hi Monocyte Recruitment to Sites of Atherosclerosis in Mice

An, G., Wang, H., Tang, R., Yago, T., McDaniel, J. M., McGee, S., Huo, Y., & Xia, L. (2008) · Circulation · doi:10.1161/circulationaha.108.771048 · Cited by 186 · see citing works

Large Scale Identification of Proteins, Mucins, and Their O-Glycosylation in the Endocervical Mucus during the Menstrual Cycle

Björkman, Y. A., Thomsson, K. A., Larsson, J. M. H., Ekerhovd, E., & Hansson, G. C. (2007) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m600439-mcp200 · Cited by 184 · see citing works

Molecular Cloning and Characterization of a Novel UDP-GlcNAc:GalNAc-peptide β1,3-N-Acetylglucosaminyltransferase (β3Gn-T6), an Enzyme Synthesizing the Core 3 Structure of O-Glycans

Iwai, T., Inaba, N., Naundorf, A., Zhang, Y., Gotoh, M., Iwasaki, H., Kudo, T., Togayachi, A., Ishizuka, Y., Nakanishi, H., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112457200 · Cited by 176 · see citing works

Composition of human colonic mucin. Selective alteration in inflammatory bowel disease.

Podolsky, D. K., & Isselbacher, K. J. (1983) · Journal of Clinical Investigation · doi:10.1172/jci110952 · Cited by 176 · see citing works

The primary defect in experimental ileitis originates from a nonhematopoietic source

Olson, T. S., Reuter, B. K., Scott, K. G. –., MORRIS, M. A., Wang, X.-M., Hancock, L. N., Burcin, T. L., Cohn, S. M., Ernst, P. B., Cominelli, F., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20050407 · Cited by 172 · see citing works

Sulphation and secretion of the predominant secretory human colonic mucin MUC2 in ulcerative colitis

van Klinken, B. J., van der Wal, J. G., Einerhand, A. W. C., Büller, H. A., & Dekker, J. P. (1999) · Gut · doi:10.1136/gut.44.3.387 · Cited by 161 · see citing works

Regulation of protein O-glycosylation by the endoplasmic reticulum–localized molecular chaperone Cosmc

Ju, T., Aryal, R. P., Stowell, C. J., & Cummings, R. D. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200711151 · Cited by 135 · see citing works

Purification, Characterization, and Subunit Structure of Rat Core 1 β1,3-Galactosyltransferase

Ju, T., Cummings, R. D., & Canfield, W. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109056200 · Cited by 117 · see citing works

Colonic mucins in ulcerative colitis: evidence for loss of sulfation

Corfield, A. P., Myerscough, N., Bradfield, N., Corfield, C. D. A., Gough, M., Clamp, J. R., Durdey, P., Warren, B. F., Bartolo, D. C. C., King, K. R., et al. (1996) · Glycoconjugate Journal · doi:10.1007/bf00702345 · Cited by 98 · see citing works

Fertilization in mouse does not require terminal galactose or N-acetylglucosamine on the zona pellucida glycans

Williams, S. A., Xia, L., Cummings, R. D., McEver, R. P., & Stanley, P. (2007) · Journal of Cell Science · doi:10.1242/jcs.004291 · Cited by 75 · see citing works

The Glycosylation of Rat Intestinal Muc2 Mucin Varies between Rat Strains and the Small and Large Intestine

Karlsson, N. G., Herrmann, A., Karlsson, H., Johansson, M., Carlstedt, I., & Hansson, G. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.43.27025 · Cited by 60 · see citing works

Molecular Cloning of a cDNA Coding for a Region of an Apoprotein from the "Insoluble" Mucin Complex of Rat Small Intestine

Hansson, G. C., Baeckström, D., Carlstedt, I., & Klinga‐Levan, K. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1026 · Cited by 51 · see citing works

Alterations in mucosal content of colonic glycoconjugates in inflammatory bowel disease defined by monoclonal antibodies

Podolsky, D. K., & Fournier, D. A. (1988) · Gastroenterology · doi:10.1016/0016-5085(88)90494-5 · Cited by 50 · see citing works

Altered expression of mucins throughout the colon in ulcerative colitis.

Smithson, J., Campbell, A., Andrews, J. M., Milton, J. D., Pigott, R., & Jewell, D. P. (1997) · Gut · doi:10.1136/gut.40.2.234 · Cited by 44 · see citing works

Colonic mucus and ulcerative colitis.

Rhodes, J. M. (1997) · Gut · doi:10.1136/gut.40.6.807 · Cited by 27 · see citing works

Mucosal Epithelium in Health and Disease

Ponda, P., & Mayer, L. (2005) · Current Molecular Medicine · doi:10.2174/1566524054863933 · Cited by 22 · see citing works

The gut microbiota--masters of host development and physiology

Sommer, F., & Bäckhed, F. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro2974 · Cited by 3,681 · see citing works

A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility

Desai, M. S., Seekatz, A. M., Koropatkin, N. M., Kamada, N., Hickey, C. A., Wolter, M., Pudlo, N. A., Kitamoto, S., Terrapon, N., Muller, A., et al. (2016) · Cell · doi:10.1016/j.cell.2016.10.043 · Cited by 2,805 · see citing works

Genetics and pathogenesis of inflammatory bowel disease

Khor, B., Gardet, A., & Xavier, R. J. (2011) · Nature · doi:10.1038/nature10209 · Cited by 2,629 · see citing works

Mucus barrier, mucins and gut microbiota: the expected slimy partners?

Paone, P., & Cani, P. D. (2020) · Gut · doi:10.1136/gutjnl-2020-322260 · Cited by 1,602 · see citing works

The gastrointestinal mucus system in health and disease

Johansson, M. E. V., Sjövall, H., & Hansson, G. C. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.35 · Cited by 1,438 · see citing works

The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system

Pelaseyed, T., Bergström, J. H., Gustafsson, J. K., Ermund, A., Birchenough, G. M. H., Schütte, A., van der Post, S., Svensson, F., Rodríguez‐Piñeiro, A. M., Nyström, E. E. L., et al. (2014) · Immunological Reviews · doi:10.1111/imr.12182 · Cited by 1,363 · see citing works

Potential of fecal microbiota for early-stage detection of colorectal cancer

Zeller, G., Tap, J., Voigt, A. Y., Sunagawa, S., Kultima, J. R., Costea, P. I., Amiot, A., Böhm, J., Brunetti, F., Habermann, N., et al. (2014) · Molecular Systems Biology · doi:10.15252/msb.20145645 · Cited by 1,375 · see citing works

The composition of the gut microbiota throughout life, with an emphasis on early life

Rodríguez, J. M., Murphy, K., Stanton, C., Ross, R. P., Kober, O. I., Juge, N., Avershina, E., Rudi, K., Narbad, A., Jenmalm, M. C., et al. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.26050 · Cited by 1,320 · see citing works

The intestinal epithelial barrier: a therapeutic target?

Odenwald, M. A., & Turner, J. R. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.169 · Cited by 1,288 · see citing works

Immunological aspects of intestinal mucus and mucins

Johansson, M. E. V., & Hansson, G. C. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.88 · Cited by 1,007 · see citing works

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

Johansson, M. E. V., Gustafsson, J. K., Holmén-Larsson, J., Jabbar, K. S., Xia, L., Xu, H., Ghishan, F. K., Carvalho, F. A., Gewirtz, A. T., Sjövall, H., et al. (2014) · Gut · doi:10.1136/gutjnl-2012-303207 · Cited by 1,004 · see citing works

Dextran sodium sulfate colitis murine model: An indispensable tool for advancing our understanding of inflammatory bowel diseases pathogenesis

Eichele, D. D., & Kharbanda, K. K. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i33.6016 · Cited by 888 · see citing works

Mucin glycan foraging in the human gut microbiome

Tailford, L. E., Crost, E. H., Kavanaugh, D. W., & Juge, N. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00081 · Cited by 851 · see citing works

Experimental Models of Inflammatory Bowel Diseases

Kiesler, P., Fuss, I. J., & Strober, W. (2015) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2015.01.006 · Cited by 719 · see citing works

Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration

Schroeder, B. O., Birchenough, G. M. H., Ståhlman, M., Arike, L., Johansson, M. E. V., Hansson, G. C., & Bäckhed, F. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2017.11.004 · Cited by 713 · see citing works

Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier

Martens, E. C., Neumann, M., & Desai, M. S. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0036-x · Cited by 711 · see citing works

The composition of the gut microbiota shapes the colon mucus barrier

Jakobsson, H. E., Rodríguez‐Piñeiro, A. M., Schütte, A., Ermund, A., Boysen, P., Bemark, M., Sommer, F., Bäckhed, F., Hansson, G. C., & Johansson, M. E. (2015) · The EMBO Reports · doi:10.15252/embr.201439263 · Cited by 700 · see citing works

The role of goblet cells and mucus in intestinal homeostasis

Gustafsson, J. K., & Johansson, M. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00675-x · Cited by 698 · see citing works

Mucins: A biologically relevant glycan barrier in mucosal protection

Corfield, A. P. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.05.003 · Cited by 567 · see citing works

Composition and functional role of the mucus layers in the intestine

Johansson, M., Ambort, D., Pelaseyed, T., Schutte, A. H., Gustafsson, J. K., Ermund, A., Subramani, D. B., Holmén‐Larsson, J., Thomsson, K. A., Bergström, J. H., et al. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0822-3 · Cited by 559 · see citing works

Normalization of host intestinal mucus layers requires long-term microbial colonization

Johansson, M. E. V., Jakobsson, H. E., Holmén-Larsson, J., Schütte, A., Ermund, A., Rodríguez-Piñeiro, A. M., Arike, L., Wising, C., Svensson, F., Bäckhed, F., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.10.007 · Cited by 549 · see citing works

Polysaccharide Degradation by the Intestinal Microbiota and Its Influence on Human Health and Disease

Cockburn, D. W., & Koropatkin, N. M. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.06.021 · Cited by 542 · see citing works

Role of mucus layers in gut infection and inflammation

Hansson, G. C. (2011) · Current Opinion in Microbiology · doi:10.1016/j.mib.2011.11.002 · Cited by 473 · see citing works

Mucins in Intestinal Mucosal Defense and Inflammation: Learning From Clinical and Experimental Studies

Grondin, J. A., Kwon, Y. H., Far, P. M., Haq, S., & Khan, W. I. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02054 · Cited by 468 · see citing works

Quantitative imaging of gut microbiota spatial organization

Earle, K. A., Billings, G., Sigal, M., Lichtman, J. S., Hansson, G. C., Elias, J. E., Amieva, M. R., Huang, K. C., & Sonnenburg, J. L. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.09.002 · Cited by 433 · see citing works

Inflammatory and Microbiota-Related Regulation of the Intestinal Epithelial Barrier

Barbara, G., Barbaro, M. R., Fuschi, D., Palombo, M., Falangone, F., Cremon, C., Marasco, G., & Stanghellini, V. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.718356 · Cited by 420 · see citing works

Layered defense: how mucus and tight junctions seal the intestinal barrier

Capaldo, C., Powell, D. N., & Kalman, D. (2017) · Journal of Molecular Medicine · doi:10.1007/s00109-017-1557-x · Cited by 375 · see citing works

Maintenance of intestinal homeostasis by mucosal barriers

Okumura, R., & Takeda, K. (2018) · Inflammation and Regeneration · doi:10.1186/s41232-018-0063-z · Cited by 368 · see citing works

Mucin-type O-glycans and their roles in intestinal homeostasis

Bergstrom, K. S. B., & Xia, L. (2013) · Glycobiology · doi:10.1093/glycob/cwt045 · Cited by 360 · see citing works

Intestinal epithelial glycosylation in homeostasis and gut microbiota interactions in IBD

Kudelka, M. R., Stowell, S. R., Cummings, R. D., & Neish, A. S. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0331-7 · Cited by 356 · see citing works

Modulation of immune development and function by intestinal microbiota

Kabat, A. M., Srinivasan, N., & Maloy, K. J. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.07.010 · Cited by 312 · see citing works

Microbial adhesins to gastrointestinal mucus

Juge, N. (2011) · Trends in Microbiology · doi:10.1016/j.tim.2011.10.001 · Cited by 304 · see citing works

MUC2 and related bacterial factors: Therapeutic targets for ulcerative colitis

Yao, D., Dai, W., Dong, M., Dai, C., & Wu, S. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103751 · Cited by 301 · see citing works

Intestinal mucus and their glycans: A habitat for thriving microbiota

Luis, A. S., & Hansson, G. C. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.05.026 · Cited by 290 · see citing works

Bifidobacterium dentium Fortifies the Intestinal Mucus Layer via Autophagy and Calcium Signaling Pathways

Engevik, M. A., Luk, B., Chang‐Graham, A. L., Hall, A., Herrmann, B. I., Ruan, W. H., Endres, B. T., Shi, Z., Garey, K. W., Hyser, J. M., et al. (2019) · mBio · doi:10.1128/mbio.01087-19 · Cited by 271 · see citing works

Mucin-type O-Glycosylation during Development

Tran, D. T., & Hagen, K. G. T. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.r112.418558 · Cited by 270 · see citing works

The mucosal barrier at a glance

France, M. M., & Turner, J. R. (2017) · Journal of Cell Science · doi:10.1242/jcs.193482 · Cited by 268 · see citing works

Animal Models of Inflammatory Bowel Disease

Mizoguchi, A. (2011) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-394596-9.00009-3 · Cited by 271 · see citing works

Simple Sugars to Complex Disease—Mucin-Type O-Glycans in Cancer

Kudelka, M. R., Ju, T., Heimburg‐Molinaro, J., & Cummings, R. D. (2015) · Advances in cancer research · doi:10.1016/bs.acr.2014.11.002 · Cited by 260 · see citing works

IL-10 Promotes Production of Intestinal Mucus by Suppressing Protein Misfolding and Endoplasmic Reticulum Stress in Goblet Cells

Hasnain, S. Z., Tauro, S., Das, I., Tong, H., Chen, A. C. –., Jeffery, P. L., McDonald, V., Florin, T. H., & McGuckin, M. A. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.10.043 · Cited by 251 · see citing works

The Critical Roles of Polysaccharides in Gut Microbial Ecology and Physiology

Porter, N. T., & Martens, E. C. (2017) · Annual Review of Microbiology · doi:10.1146/annurev-micro-102215-095316 · Cited by 251 · see citing works

Nanoparticulate drug delivery systems targeting inflammation for treatment of inflammatory bowel disease

Zhang, S., Langer, R., & Traverso, G. (2017) · Nano Today · doi:10.1016/j.nantod.2017.08.006 · Cited by 255 · see citing works

Proximal colon–derived O-glycosylated mucus encapsulates and modulates the microbiota

Bergstrom, K., Shan, X., Casero, D., Batushansky, A., Lagishetty, V., Jacobs, J. P., Hoover, C., Kondo, Y., Shao, B., Gao, L., et al. (2020) · Science · doi:10.1126/science.aay7367 · Cited by 248 · see citing works

The gut commensal Blautia maintains colonic mucus function under low-fiber consumption through secretion of short-chain fatty acids

Holmberg, S. M., Feeney, R. H., K., V., Puértolas-Balint, F., Singh, D. K., Wongkuna, S., Zandbergen, L. M., Hauner, H., Brandl, B., Nieminen, A. I., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47594-w · Cited by 252 · see citing works

Microbiota-mediated inflammation and antimicrobial defense in the intestine

Caballero, S., & Pamer, E. G. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120238 · Cited by 238 · see citing works

Alterations in the Intestinal Microbiome (Dysbiosis) as a Predictor of Relapse After Infliximab Withdrawal in Crohnʼs Disease

Rajca, S., Grondin, V., Louis, E. J., Vernier-Massouille, G., Grimaud, J., Bouhnik, Y., Laharie, D., Dupas, J., Pillant, H., Picon, L., et al. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000036 · Cited by 236 · see citing works

Multi-omics reveal microbial determinants impacting responses to biologic therapies in inflammatory bowel disease

Lee, J. W. J., Plichta, D. R., Hogstrom, L. J., Borren, N. Z., Lau, H., Gregory, S. M., Tan, W., Khalili, H., Clish, C. B., Vlamakis, H. C., et al. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2021.06.019 · Cited by 235 · see citing works

The Densely O-Glycosylated MUC2 Mucin Protects the Intestine and Provides Food for the Commensal Bacteria

Arike, L., & Hansson, G. C. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.02.010 · Cited by 225 · see citing works

The influence of the gut microbiome on obesity, metabolic syndrome and gastrointestinal disease

Parekh, P. J., Balart, L. A., & Johnson, D. A. (2015) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2015.16 · Cited by 219 · see citing works

The Role of the Gastrointestinal Mucus System in Intestinal Homeostasis: Implications for Neurological Disorders

Herath, M., Hosie, S., Bornstein, J. C., Franks, A. E., & Hill‐Yardin, E. L. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00248 · Cited by 214 · see citing works

Immune regulatory networks coordinated by glycans and glycan-binding proteins in autoimmunity and infection

Pinho, S. S., Alves, I., Gaifem, J., & Rabinovich, G. A. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01074-1 · Cited by 216 · see citing works

Fast Renewal of the Distal Colonic Mucus Layers by the Surface Goblet Cells as Measured by In Vivo Labeling of Mucin Glycoproteins

Johansson, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041009 · Cited by 205 · see citing works

Studies of mucus in mouse stomach, small intestine, and colon. III. Gastrointestinal Muc5ac and Muc2 mucin O -glycan patterns reveal a regiospecific distribution

Larsson, J. M. H., Thomsson, K. A., Rodríguez-Piñeiro, A. M., Karlsson, H., & Hansson, G. C. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00048.2013 · Cited by 207 · see citing works

Reprograming of gut microbiome energy metabolism by the FUT2 Crohn’s disease risk polymorphism

Tong, M., McHardy, I. H., Ruegger, P. M., Goudarzi, M., Kashyap, P., Haritunians, T., Li, X., Graeber, T. G., Schwager, E., Huttenhower, C., et al. (2014) · The ISME Journal · doi:10.1038/ismej.2014.64 · Cited by 206 · see citing works

A single sulfatase is required to access colonic mucin by a gut bacterium

Luis, A. S., Jin, C., Pereira, G. V., Glowacki, R. W. P., Schaus, S. R., Singh, S., Byrne, D. P., Pudlo, N. A., London, J. A., Baslé, A., et al. (2021) · Nature · doi:10.1038/s41586-021-03967-5 · Cited by 199 · see citing works

The Stromal Intervention: Regulation of Immunity and Inflammation at the Epithelial-Mesenchymal Barrier

Nowarski, R., Jackson, R., & Flavell, R. A. (2017) · Cell · doi:10.1016/j.cell.2016.11.040 · Cited by 191 · see citing works

Core 1– and 3–derived O-glycans collectively maintain the colonic mucus barrier and protect against spontaneous colitis in mice

Bergstrom, K., Fu, J., Johansson, M., Liu, X., Gao, N., Wu, Q., Song, J., McDaniel, J. M., McGee, S., Chen, W., et al. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.45 · Cited by 190 · see citing works

Symbiotic Human Gut Bacteria with Variable Metabolic Priorities for Host Mucosal Glycans

Pudlo, N. A., Urs, K., Kumar, S. S., German, J. B., Mills, D. A., & Martens, E. C. (2015) · mBio · doi:10.1128/mbio.01282-15 · Cited by 187 · see citing works

Mucosal Barrier, Bacteria and Inflammatory Bowel Disease: Possibilities for Therapy

Merga, Y., Campbell, B. J., & Rhodes, J. M. (2014) · Digestive Diseases · doi:10.1159/000358156 · Cited by 180 · see citing works

A refined palate: Bacterial consumption of host glycans in the gut

Marcobal, A. M., Southwick, A. M., Earle, K. A., & Sonnenburg, J. L. (2013) · Glycobiology · doi:10.1093/glycob/cwt040 · Cited by 178 · see citing works

Experimental models to study intestinal microbes–mucus interactions in health and disease

Etienne‐Mesmin, L., Chassaing, B., Desvaux, M., Paepe, K. D., Gresse, R., Sauvaitre, T., Forano, É., de Wiele, T. V., Schüller, S., Juge, N., et al. (2019) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuz013 · Cited by 178 · see citing works

A Modular Organization of the Human Intestinal Mucosal Microbiota and Its Association with Inflammatory Bowel Disease

Tong, M., Li, X., Parfrey, L. W., Roth, B. E., Ippoliti, A., Wei, B., Borneman, J., McGovern, D. P. B., Frank, D. N., Li, E., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080702 · Cited by 176 · see citing works

A slippery slope: On the origin, role and physiology of mucus

Taherali, F., Varum, F., & Basit, A. W. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.10.014 · Cited by 171 · see citing works

Pathogens, microbiome and the host: emergence of the ecological Koch's postulates

Vonaesch, P., Anderson, M. C., & Sansonetti, P. J. (2018) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuy003 · Cited by 170 · see citing works

Inflammatory Bowel Disease Associates with Proinflammatory Potential of the Immunoglobulin G Glycome

Trbojević‐Akmačić, I., Ventham, N. T., Τheodoratou, E., Vučković, F., Kennedy, N. A., Krištić, J., Nimmo, E. R., Kalla, R., Drummond, H. E., Štambuk, J., et al. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000372 · Cited by 169 · see citing works

Global functions of O‐glycosylation: promises and challenges in O‐glycobiology

Wandall, H. H., Nielsen, M. I., King‐Smith, S., de Haan, N., & Bagdonaite, I. (2021) · FEBS Journal · doi:10.1111/febs.16148 · Cited by 165 · see citing works

T n and sialyl‐Tn antigens, aberrant O ‐glycomics as human disease markers

Ju, T., Wang, Y., Aryal, R. P., Lehoux, S. D., Ding, X., Kudelka, M. R., Cutler, C. E., Zeng, J., Wang, J., Sun, X., et al. (2013) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201300024 · Cited by 165 · see citing works

Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice

Bergstrom, K., Liu, X., Zhao, Y., Gao, N., Wu, Q., Song, K., Cui, Y. W., Li, Y., McDaniel, J. M., McGee, S., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.03.039 · Cited by 163 · see citing works

Targeted colonic claudin-2 expression renders resistance to epithelial injury, induces immune suppression, and protects from colitis

Ahmad, R., Chaturvedi, R., Olivares–Villagómez, D., Habib, T., Asim, M., Punit, S., Polk, D. B., Wilson, K. T., Washington, M. K., Kaer, L. V., et al. (2014) · Mucosal Immunology · doi:10.1038/mi.2014.21 · Cited by 162 · see citing works

The role of glycosylation in IBD

Τheodoratou, E., Campbell, H. J., Ventham, N. T., Kolarich, D., Pučić‐Baković, M., Zoldoš, V., Fernandes, D. L., Pemberton, I. K., Rudan, I., Kennedy, N. A., et al. (2014) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2014.78 · Cited by 159 · see citing works

The Cosmc connection to the Tn antigen in cancer

Ju, T., Aryal, R. P., Kudelka, M. R., Wang, Y., & Cummings, R. D. (2014) · Cancer Biomarkers · doi:10.3233/cbm-130375 · Cited by 153 · see citing works

Intrinsic Defense Mechanisms of the Intestinal Epithelium

Ramanan, D., & Cadwell, K. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.03.003 · Cited by 153 · see citing works

The Role and Function of Mucins and Its Relationship to Inflammatory Bowel Disease

Kang, Y., Park, H., Choe, B., & Kang, B. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.848344 · Cited by 152 · see citing works

Mucin Function in Inflammatory Bowel Disease

Boltin, D., Perets, T. T., Vilkin, A., & Niv, Y. (2012) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3182688e73 · Cited by 151 · see citing works

Altered Mucus Glycosylation in Core 1 O-Glycan-Deficient Mice Affects Microbiota Composition and Intestinal Architecture

Sommer, F., Adam, N., Johansson, M., Xia, L., Hansson, G. C., & Bäckhed, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085254 · Cited by 150 · see citing works

Activated ATF6 Induces Intestinal Dysbiosis and Innate Immune Response to Promote Colorectal Tumorigenesis.

Coleman, O., Lobner, E. M., Bierwirth, S., Sorbie, A., Waldschmitt, N., Rath, E., Berger, E., Lagkouvardos, I., Clavel, T., McCoy, K., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.07.028 · Cited by 125 · see citing works

Mucus Layers in Inflammatory Bowel Disease

Johansson, M. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000117 · Cited by 148 · see citing works

The role of O-glycosylation in human disease

Magalhães, A., Duarte, H. O., & Reis, C. A. (2021) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2021.100964 · Cited by 148 · see citing works

Activation of Epidermal Growth Factor Receptor Mediates Mucin Production Stimulated by p40, a Lactobacillus rhamnosus GG-derived Protein

Wang, L., Cao, H., Liu, L., Wang, B., Walker, W. A., Acra, S. A., & Yan, F. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.553800 · Cited by 146 · see citing works

Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown

Crouch, L. I., Liberato, M. V., Urbanowicz, P. A., Baslé, A., Lamb, C. A., Stewart, C. J., Cooke, K., Doona, M., Needham, S. J., Brady, R. R. W., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17847-5 · Cited by 146 · see citing works

Arabinoxylan structural characteristics, interaction with gut microbiota and potential health functions

Chen, Z., Li, S., Fu, Y., Li, C., Chen, D., & Chen, H. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.02.007 · Cited by 143 · see citing works

Protein Glycosylation as a Diagnostic and Prognostic Marker of Chronic Inflammatory Gastrointestinal and Liver Diseases

Verhelst, X., Dias, A. M., Colombel, J., Vermeire, S., Vlierberghe, H. V., Callewaert, N., & Pinho, S. S. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.08.060 · Cited by 144 · see citing works

GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway

Kiryluk, K., Li, Y., Moldoveanu, Z., Suzuki, H., Reily, C., Hou, P., Xie, J., Mladkova, N., Prakash, S., Fischman, C. J., et al. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006609 · Cited by 138 · see citing works

The intestinal epithelium as guardian of gut barrier integrity

Zhang, K., Hornef, M. W., & Dupont, A. (2015) · Cellular Microbiology · doi:10.1111/cmi.12501 · Cited by 138 · see citing works

HumanClostridium difficileinfection: altered mucus production and composition

Engevik, M. A., Yacyshyn, M. B., Engevik, K. A., Wang, J., Darien, B. J., Hassett, D. J., Yacyshyn, B., & Worrell, R. T. (2015) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00091.2014 · Cited by 135 · see citing works

The Interaction of the Gut Microbiota with the Mucus Barrier in Health and Disease in Human

Corfield, A. P. (2018) · Microorganisms · doi:10.3390/microorganisms6030078 · Cited by 134 · see citing works

The potter’s wheel: the host’s role in sculpting its microbiota

Bevins, C. L., & Salzman, N. H. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0830-3 · Cited by 128 · see citing works

The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or function

Volk, J. K., Nyström, E. E. L., van der Post, S., Martínez‐Abad, B., Schroeder, B. O., Johansson, Å., Svensson, F. R., Jäverfelt, S., Johansson, M., Hansson, G. C., et al. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20190679 · Cited by 128 · see citing works

Microbiome and immunological interactions

Kelly, D., & Mulder, I. E. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00498.x · Cited by 127 · see citing works

Autophagy Protects against Colitis by the Maintenance of Normal Gut Microflora and Secretion of Mucus

Tsuboi, K., Nishitani, M., Takakura, A., Imai, Y., Komatsu, M., & Kawashima, H. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.632257 · Cited by 125 · see citing works

Spontaneous Colitis in Muc2-Deficient Mice Reflects Clinical and Cellular Features of Active Ulcerative Colitis

Wenzel, U. A., Magnusson, M. K., Rydström, A., Jonstrand, C., Hengst, J., Johansson, M., Velcich, A., Öhman, L., Strid, H., Sjövall, H., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100217 · Cited by 125 · see citing works

Inflammatory caspase-related pyroptosis: mechanism, regulation and therapeutic potential for inflammatory bowel disease

Yuan, Y., Xie, K.-X., Wang, S.-L., & Yuan, L. (2018) · Gastroenterology report · doi:10.1093/gastro/goy011 · Cited by 122 · see citing works

The long-term consequences of antibiotic therapy: Role of colonic short-chain fatty acids (SCFA) system and intestinal barrier integrity

Holota, Y., Dovbynchuk, T., Kaji, I., Vareniuk, І., Dzyubenko, N., Chervinska, T., Zakordonets, L. V., Стецька, В. О., Остапченко, Л. І., Serhiichuk, T., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0220642 · Cited by 121 · see citing works

Mucus and the Goblet Cell

Johansson, M., & Hansson, G. C. (2013) · Digestive Diseases · doi:10.1159/000354683 · Cited by 119 · see citing works

Sialylation on O-glycans protects platelets from clearance by liver Kupffer cells

Li, Y., Fu, J., Ling, Y., Yago, T., McDaniel, J. M., Song, J., Bai, X., Kondo, Y., Qin, Y., Hoover, C., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1707662114 · Cited by 119 · see citing works

Ischaemia-induced mucus barrier loss and bacterial penetration are rapidly counteracted by increased goblet cell secretory activity in human and rat colon

Grootjans, J., Hundscheid, I. H. R., Lenaerts, K., Boonen, B., Renes, I. B., Verheyen, F., Dejong, C. H. C., MEYENFELDT, M. F. V., Beets, G. L., & Buurman, W. A. (2012) · Gut · doi:10.1136/gutjnl-2011-301956 · Cited by 109 · see citing works

Role for diet in normal gut barrier function: developing guidance within the framework of food-labeling regulations

Camilleri, M., Lyle, B. J., Madsen, K. L., Sonnenburg, J. L., Verbeke, K., & Wu, G. D. (2019) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00063.2019 · Cited by 111 · see citing works

Carbohydrates great and small, from dietary fiber to sialic acids: How glycans influence the gut microbiome and affect human health

Coker, J. K. C., Moyne, O., Rodionov, D. A., & Zengler, K. (2021) · Gut Microbes · doi:10.1080/19490976.2020.1869502 · Cited by 112 · see citing works

Chemically Induced Intestinal Damage Models in Zebrafish Larvae

Oehlers, S. H., Flores, M. V., Hall, C. J., Okuda, K. S., Sison, J. O., Crosier, K. E., & Crosier, P. S. (2013) · Zebrafish · doi:10.1089/zeb.2012.0824 · Cited by 107 · see citing works

Colon-targeted delivery of budesonide using dual pH- and time-dependent polymeric nanoparticles for colitis therapy

Yoo, J., Naeem, M., Choi, M., Cao, J., Yoon, S., Kim, M., Jung, Y., Lee, J., Moon, H. R., Ikram, M., et al. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s88672 · Cited by 108 · see citing works

In brief

(2011) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2011.46

Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice

Bergstrom, K., Liu, X., Zhao, Y., Gao, N., Wu, Q., Song, K., Cui, Y. W., Li, Y., McDaniel, J. M., McGee, S., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.03.039 · Cited by 163 · see citing works

P-162 Core 1- and Core 3-Derived Mucin-Type O-Glycans Collectively Maintain the Colonic Mucus Barrier and Protect Against Spontaneous Colitis in Mice

Bergstrom, K., Fu, J., & Xia, L. (2016) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000480280.44871.a3 · Cited by 3 · see citing works

O-038 Loss of Intestinal Mucin-type O-glycans Promotes Inflammation-Associated Colon Cancer in an Inflammasome-Dependent Manner

Bergstrom, K., & Lijun, X. (2014) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000456696.47986.df

Increased susceptibility to colitis and colorectal tumors in mice lacking core 3–derived O-glycans

An, G., Wei, B., Xia, B., McDaniel, J. M., Ju, T., Cummings, R. D., Braun, J., & Xia, L. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061929 · Cited by 352 · see citing works