pH-Responsive Lignin-Based Nanomicelles for Oral Drug Delivery
Abstract
A pH-stimuli amphiphilic lignin-based copolymer was prepared, and it could self-assemble to form spherical nanomicelles with the addition of "switching" water. The morphology, structure, and physical properties of micelles were characterized with transmission electron microscopy (TEM), nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FTIR), gel permeation chromatography (GPC), particle-size analysis, and zeta-potential measurement. In vitro drug release exemplified that the micelles were pH-sensitive, retaining more than 84.36% ibuprofen (IBU) in simulated gastric fluid (pH 1.5) and presenting a smooth release of 81.81% IBU in simulated intestinal fluid (pH 7.4) within 72 h. Cell culture studies showed that the nanomicelles were biocompatible and boosted the proliferation of human bone marrow stromal cells hBMSC and mouse embryonic fibroblast cells NIH-3T3. Interestingly, the nanomicelles inhibited the survival of human colon cancer cells HT-29 with a final survival rate of only 5.34%. Therefore, this work suggests a novel strategy to synthesize intelligent lignin-based nanomicelles that show a great potential as oral drug carriers.
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The IBU drug was released from the core of modified lignin micelles within 72 h in an acidic environment.
“The results showed that the IBU drug was released from the core of the developed micelles within 72 h in an acidic environment (Figure 9).”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [169]
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Lignin valorization: Status, challenges and opportunities
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“Similarly, smart micelles-based modified lignin for ibuprofen (IBU) delivery has been proposed by Cheng and coworkers [169].”
Background
- Authors
- Cheng, L., Deng, B., Luo, W., Nie, S., Liu, X., Yin, Y., Liu, S., Wu, Z., Zhan, P., Zhang, L., & Chen, J.
- Affiliations
- Central South University of Forestry and Technology (CN)
- Corresponding author
- Luo, Weihua
- Chen, Jienan
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-04-14
- Volume
- 68
- Issue
- 18
- Pages
- 5249-5258
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W3015771470
- Cited by
- 77
- References
- 63
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 14 · 2023: 16 · 2022: 19 · 2021: 8 · 2020: 4
- FWCI
- 3.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Agricultural and Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Science and Technology of the People's Republic of China (2018YFD0600302)
- Natural Science Foundation of Hunan Province (2015JJ2200)
- National Natural Science Foundation of China (31770606, 31890774)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Lignin and Wood Chemistry
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- oral drug delivery, amphiphilic polymers, self-assembly, ibuprofen release, simulated gastric fluid, simulated intestinal fluid, biocompatibility, mesenchymal stem cells, colon cancer cells, drug carriers
- MeSH terms
- Animals, Cell Line, Drug Carriers, Humans, Hydrogen-Ion Concentration, Ibuprofen, Lignin, Micelles, Particle Size, Drug Delivery Systems, Mice, Drug Liberation
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