Microwave-Assisted Isolation of Eugenol from Cloves
Abstract
An experiment for the undergraduate organic chemistry laboratory involving a method for the isolation of eugenol from cloves has been developed. The experiment employs microwave-assisted extraction (MAE) of the essential oil from whole cloves using aqueous ethanol and the subsequent isolation of eugenol by acid–base extraction. The MAE allows for extraction of the essential oil in a fraction of the time of steam-distillation, which is commonly part of a second-year undergraduate laboratory experience. The experiment combines multiple lab techniques and reinforces the introduction of spectroscopy in first-semester organic chemistry.
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Advanced extraction methods improve organic compound extraction yield by applying microwave or ultrasonic energy, which can destroy the cell walls of the plant matrix, allowing compounds to flow better from the biological material.
“These methods improve organic compound extraction yield by applying microwave or ultrasonic energy, which can destroy the cell walls of the plant matrix, allowing the compounds to flow better from the biological material [5,15,21].”
From Clove essential oil (Syzygium aromaticum L. Myrtaceae): Extraction, chemical composition, food applications, and essential bioactivity for human health (2021) · cites this paper as [15]
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Haro-González, J. N., Castillo-Herrera, G. A., Martínez-Velázquez, M., & Espinosa-Andrews, H. (2021) · Molecules · doi:10.3390/molecules26216387 · Cited by 463 · see citing works
- Authors
- Overly, K. R.
- Affiliations
- Providence College (US)
- Corresponding author
- Overly, Kenneth R.
- ORCID
- Overly, Kenneth R.
- Venue
- Journal of Chemical Education
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-10-17
- Volume
- 96
- Issue
- 11
- Pages
- 2665-2667
- ISSN
- 0021-9584 (ISSN-L)
- 1938-1328
- OpenAlex
- W2981269265
- Cited by
- 14
- References
- 11
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 1
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Chemical Education (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Various Chemistry Research Topics
- Physical Sciences › Chemistry › Organic Chemistry › Microwave-Assisted Synthesis and Applications
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Keywords
- eugenol, Syzygium aromaticum, microwave-assisted extraction, essential oil extraction, acid-base extraction, aqueous ethanol extraction, undergraduate organic chemistry laboratory, spectroscopy
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