The DOI matches its Crossref record; 177 of the 178 references it cites were found in a registry or an index.
Selective Estrogen Receptor Degraders (SERDs): A Promising Strategy for Estrogen Receptor Positive Endocrine-Resistant Breast Cancer
Abstract
Estrogen receptor (ER) plays important roles in gene transcription and the proliferation of ER positive breast cancers. Selective modulation of ER has been a therapeutic target for this specific type of breast cancer for more than 30 years. Selective estrogen receptor modulators (SERMs) and aromatase inhibitors (AIs) have been demonstrated to be effective therapeutic approaches for ER positive breast cancers. Unfortunately, 30-50% of ER positive tumors become resistant to SERM/AI treatment after 3-5 years. Fulvestrant, the only approved selective estrogen receptor degrader (SERD), is currently an important therapeutic approach for the treatment of endocrine-resistant breast cancers. The poor pharmacokinetic properties of fulvestrant have inspired the development of a new generation of oral SERDs to overcome drug resistance. In this review, we describe recent advances in ERα structure, functions, and mechanisms of endocrine resistance and summarize the development of oral SERDs in both academic and industrial areas.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Fulvestrant is a standard therapeutic option for endocrine-resistant or advanced metastatic ER+ breast cancer59,60.”
From Harnessing artificial intelligence to identify Bufalin as a molecular glue degrader of estrogen receptor alpha (2025) · cites this paper as [60]
Citations
Cites
1 retracted
Wong, C., McNally, C., Nickbarg, E., Komm, B. S., & Cheskis, B. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192569699 · Cited by 321
RetractedMolecular portraits of human breast tumours
Perou, C., Sørlie, T., Eisen, M., van de Rijn, M., Jeffrey, S., Rees, C. A., Pollack, J., Ross, D., Johnsen, H., Akslen, L., et al. (2000) · Nature · doi:10.1038/35021093 · Cited by 16,551
The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964
Molecular basis of agonism and antagonism in the oestrogen receptor
Brzozowski, A. M., Pike, A. C. W., Dauter, Z., Hubbard, R. E., Bonn, T., Engström, O., Öhman, L., Greene, G. L., Gustafsson, J.-Å., & Carlquist, M. (1997) · Nature · doi:10.1038/39645 · Cited by 3,355
Alpelisib for PIK3CA -Mutated, Hormone Receptor–Positive Advanced Breast Cancer
André, F., Ciruelos, E., Rubovszky, G., Campone, M., Loibl, S., Rugo, H. S., Iwata, H., Conte, P., Mayer, I. A., Kaufman, B., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1813904 · Cited by 2,622
Self-citationPhenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer
Prat, A., Parker, J. S., Karginova, O. A., Fan, C., Livasy, C., Herschkowitz, J. I., He, X., & Perou, C. M. (2010) · Breast Cancer Research · doi:10.1186/bcr2635 · Cited by 2,290
Metastatic Behavior of Breast Cancer Subtypes
Kennecke, H., Yerushalmi, R., Woods, R., Cheang, M. C. U., Voduc, D., Speers, C. H., Nielsen, T. O., & Gelmon, K. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.25.9820 · Cited by 2,262
Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase
Kato, S., Endoh, H., Masuhiro, Y., Kitamoto, T., Uchiyama, S., Sasaki, H., Masushige, S., Gotoh, Y., Nishida, E., Kawashima, H., et al. (1995) · Science · doi:10.1126/science.270.5241.1491 · Cited by 1,964
Nuclear Receptor Coregulators: Cellular and Molecular Biology
McKenna, N. J., Lanz, R. B., & O’Malley, B. W. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0366 · Cited by 1,941
† (2015) · The Lancet · doi:10.1016/s0140-6736(15)61074-1 · Cited by 1,550
Research works printed but not linked: 8
- Ottaviano Y. L., 1994, Cancer Res., 54, 2552
- Lapidus R. G., 1996, Clin. Cancer Res., 2, 805
- Yang X., 2001, Cancer Res., 61, 7025
- Zhang Q.-X., 1997, Cancer Res., 57, 1244
- Wakeling A. E., 1991, Cancer Res., 51, 3867
- Wakeling A., 1980, Cancer Treat. Rep., 64, 741
- Pink J. J., 1996, Cancer Res., 56, 2321
- Müller V., 1998, Cancer Res., 58, 263
Cited by
Sorted by citations
Overcoming Cancer Drug Resistance Utilizing PROTAC Technology
Burke, M. R., Smith, A. R., & Zheng, G. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.872729 · Cited by 129
Targeting the Estrogen Receptor for the Treatment of Breast Cancer: Recent Advances and Challenges
Rej, R. K., Thomas, J. E., Acharyya, R. K., Rae, J. M., & Wang, S. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c00136 · Cited by 117
Targeting Breast Cancer: An Overlook on Current Strategies
Iacopetta, D., Ceramella, J., Baldino, N., Sinicropi, M., & Catalano, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043643 · Cited by 88
Accelerating drug development in breast cancer: New frontiers for ER inhibition
Ferraro, E., Walsh, E. M., Tao, J. J., Chandarlapaty, S., & Jhaveri, K. L. (2022) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2022.102432 · Cited by 57
Chen, Z., Hu, B., Rej, R. K., Wu, D., Acharyya, R. K., Wang, M., Xu, T., Lü, J., Metwally, H., Wang, Y., et al. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c01186 · Cited by 54
Development of PROTAC Degrader Drugs for Cancer
Vetma, V., O’Connor, S., & Ciulli, A. (2024) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-061824-105806 · Cited by 55
Oral SERD, a Novel Endocrine Therapy for Estrogen Receptor-Positive Breast Cancer
Neupane, N., Bawek, S. J., Gurusinghe, S., Ghaffary, E. M., Mirmosayyeb, O., Thapa, S., Falkson, C. I., O’Regan, R. M., & Dhakal, A. (2024) · Cancers · doi:10.3390/cancers16030619 · Cited by 51
Rhabori, S. E., Alaqarbeh, M., Aissouq, A. E., Bouachrıne, M., Chtita, S., & Khalil, F. (2024) · Chemical Physics Impact · doi:10.1016/j.chphi.2023.100455 · Cited by 48
Cancer Cell‐Specific Fluorescent Prodrug Delivery Platforms
Ma, S., Kim, J. H., Chen, W., Li, L., Lee, J., Xue, J., Liu, Y., Chen, G., Tang, B., Tao, W., et al. (2023) · Advanced Science · doi:10.1002/advs.202207768 · Cited by 44
Deng, X., Xie, B., Li, Q., Xiao, Y., Hu, Z., Deng, X., Fang, P., Dong, C., Zhou, H.-B., & Huang, J. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c00525 · Cited by 43
Pharmacological insights on novel oral selective estrogen receptor degraders in breast cancer
Guglielmi, G., Re, M. D., Gol, L. S., Bengala, C., Danesi, R., & Fogli, S. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176424 · Cited by 40
Xie, B., Yin, Z., Hu, Z., Lv, J., Du, C., Deng, X., Huang, Y., Li, Q., Huang, J., Liang, K., et al. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c02032 · Cited by 39
Xin, L., Wang, C., Cheng, Y., Wang, H., Guo, X., Deng, X., Deng, X., Xie, B., Hu, H., Min, C., et al. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c00196 · Cited by 38
Mottamal, M., Kang, B.-R., Peng, X., & Wang, G. (2021) · ACS Omega · doi:10.1021/acsomega.0c06362 · Cited by 37
SERD-NHC-Au(I) complexes for dual targeting ER and TrxR to induce ICD in breast cancer
Lu, Y., Sheng, X., Liu, C., Liang, Z., Wang, X., Liu, L., Wen, Z., Yang, Z., Du, Q., & Liu, W. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106731 · Cited by 37
Self-citationSelective Estrogen receptor degraders (SERDs) for the treatment of breast cancer: An overview
Bhatia, N. S., Hazra, S., & Thareja, S. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115422 · Cited by 35
The G Protein-Coupled Estrogen Receptor (GPER): A Critical Therapeutic Target for Cancer
Hall, K. A., & Filardo, E. J. (2023) · Cells · doi:10.3390/cells12202460 · Cited by 30
Bardia, A., Cortés, J., Hurvitz, S. A., Delaloge, S., Iwata, H., Shao, Z., Kanagavel, D., Cohen, P., Liu, Q., Cartot‐Cotton, S., et al. (2022) · Therapeutic Advances in Medical Oncology · doi:10.1177/17588359221083956 · Cited by 31
Ma, C. X., Suman, V. J., Sanati, S., Vij, K. R., Anurag, M., Leitch, A. M., Unzeitig, G. W., Hoog, J., Fernández-Martínez, A., Fan, C., et al. (2024) · JAMA Oncology · doi:10.1001/jamaoncol.2023.6038 · Cited by 29
Wang, Y., Min, J., Deng, X., Feng, T., Hu, H., Guo, X., Cheng, Y., Xie, B., Yang, Y., Chen, C.-C., et al. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.05.005 · Cited by 28
Xie, B., Xu, B., Xin, L., Wei, Y., Guo, X., & Dong, C. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2023.106590 · Cited by 27
Jhaveri, K. L., Bellet, M., Turner, N. C., Loi, S., Bardia, A., Boni, V., Sohn, J., Neilan, T. G., Villanueva-Vázquez, R., Kabos, P., et al. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-1796 · Cited by 31
Elacestrant: a new FDA-approved SERD for the treatment of breast cancer
Bhatia, N., & Thareja, S. (2023) · Medical Oncology · doi:10.1007/s12032-023-02045-2 · Cited by 27
Deng, X., Deng, X., Ning, W., Xin, L., Li, Q., Hu, Z., Xie, B., Liang, K., Min, C., Dong, C., et al. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c00465 · Cited by 26
Luo, G., Lin, X., Ren, S., Wu, S., Wang, X., Ma, L., & Xiang, H. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113870 · Cited by 25
Selective Estrogen Receptor Modulators (SERMs) for the treatment of ER+ breast cancer: An overview
Das, S., Kulkarni, S., Singh, Y., Kumar, P., & Thareja, S. (2022) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2022.133853 · Cited by 25
Yan, S., Ji, J., Zhang, Z., Imam, M., Chen, H., Zhang, D., & Wang, J. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116615 · Cited by 24
Update on the Role of Neuropeptide Y and Other Related Factors in Breast Cancer and Osteoporosis
Lin, S., Li, Y., Sun, X., Chen, Q., Huang, S., Lin, S., & Cai, S. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.705499 · Cited by 24
Jiang, S., Liu, K., Jiang, T., Li, H., Wei, X., Wan, X., Zhong, C., Gong, R., Chen, Z., Zou, C., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62288-7 · Cited by 23
Acharyya, R. K., Rej, R. K., Hu, B., Chen, Z., Wu, D., Lü, J., Metwally, H., McEachern, D., Wang, Y., Jiang, W., et al. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c01521 · Cited by 24
Research Progress on Bioactive Metal Complexes against ER-Positive Advanced Breast Cancer
Liang, Z., Liu, L., Zhou, Y., Liu, W., & Lu, Y. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01458 · Cited by 24
Self-citationErtl, P., Altmann, E., & Wilcken, R. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.118178 · Cited by 24
Estrogen receptor inhibition mediates radiosensitization of ER-positive breast cancer models
Michmerhuizen, A. R., Lerner, L. M., Pesch, A. M., Ward, C., Schwartz, R. L., Wilder-Romans, K., Liu, M., Nino, C. A., Jungles, K. M., Azaria, R. D., et al. (2022) · npj Breast Cancer · doi:10.1038/s41523-022-00397-y · Cited by 22
Bhutani, K., Vishwakarma, S., Yadav, P., & Yadav, M. K. (2025) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2025.106729 · Cited by 20
McSwiggen, D. T., Liu, H., Tan, R., Puig, S. A., Akella, L. B., Berman, R., Bretan, M., Chen, H., Darzacq, X., Ford, K., et al. (2024) · eLife · doi:10.7554/elife.93183.3 · Cited by 18
Eapen, J. V., George, P. R., Thomas, S., & Antony, J. (2025) · ASPET Discovery · doi:10.1016/j.aspetd.2025.100012 · Cited by 14
Kurtanović, N., Tomašević, N., Matić, S. L., Proia, E., Sabatino, M., Antonini, L., Mladenović, M. P., & Ragno, R. (2022) · Molecules · doi:10.3390/molecules27092823 · Cited by 14
Tian, Y., Liu, K., Wu, D., Wu, L., Xu, Q., Wei, W., Li, Z., Du, Q., & Bian, J. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116275 · Cited by 14
Sharaf, B., Hajahjeh, A., Hani, H. B., & Abdel‐Razeq, H. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1385577 · Cited by 14
Emerging Roles of RNF168 in Tumor Progression
Xie, T., Qin, H., Yuan, Z., Zhang, Y., Li, X., & Zheng, L. (2023) · Molecules · doi:10.3390/molecules28031417 · Cited by 13
Abbasi, H. Q., Adeena, M., Khan, A. M., Shahnoor, S., Oduoye, M. O., & Nafula, W. P. (2023) · International Journal of Surgery · doi:10.1097/js9.0000000000000334 · Cited by 13
Liu, X.-M., Li, Z., He, X.-R., Liu, R.-P., Ma, Z., Qiao, X., Wang, S., & Xu, J. (2022) · Inorganic Chemistry Frontiers · doi:10.1039/d2qi00900e · Cited by 12
Chen, F., Wang, Y., Huang, H., Li, W., Ma, J., Yao, D., Tang, Z.-J., Xue, T., Ha, L., Ren, Y., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.651976 · Cited by 12
Liang, J., Wang, D., Wu, Y., Shi, J., Xie, B., Xiao, R., Ni, J., Wang, C., Dong, C., Shu, H., et al. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c00425 · Cited by 12
Lu, Y., Liu, C., Wang, X., Liu, L., Zhao, Z., Liang, Z., Liu, W., Wen, Z., Du, Q., & Liu, W. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115324 · Cited by 11
Self-citationBirukova, V. E., Scherbakov, A. M., Ilina, A. A., Salnikova, D. I., Andreeva, O. E., Dzichenka, Y. U., Zavarzin, I. V., & Volkova, Y. A. (2023) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2023.106309 · Cited by 11
Kurtanović, N., Stanković, N., Matić, S. L., Mitrović, M. M., Kostić, D. A., Sabatino, M., Antonini, L., Ragno, R., & Mladenović, M. P. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113869 · Cited by 11
Zhou, J., Shen, R., Liu, J., Deng, X., Xin, L., Zhou, H., & Huang, J. (2023) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2023.117235 · Cited by 9
Mihović, N., Stanković, N., Matić, S. L., Mitrović, M. M., Kostić, D. A., Sabatino, M., Antonini, L., Ragno, R., & Mladenović, M. P. (2021) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.1c00530 · Cited by 9
McSwiggen, D. T., Liu, H., Tan, R., Puig, S. A., Akella, L. B., Berman, R., Bretan, M., Chen, H., Darzacq, X., Ford, K., et al. (2023) · eLife · doi:10.7554/elife.93183 · Cited by 9
Lu, Y., Liang, Z., Liu, L., Zhou, Y., Liu, C., Zhao, Z., Zheng, T., Du, Q., & Liu, W. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116534 · Cited by 8
Self-citationVerhoog, N. J. D., & Spies, L.-M. L. (2024) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2024.106581 · Cited by 8
Zhao, S., Gu, J., Tian, Y., Wang, R., & Li, W. (2024) · Open Life Sciences · doi:10.1515/biol-2022-0822 · Cited by 9
Zhang, D., Lu, Z., He, Y., Leng, X.-Y., Meng, X., Lei, X., Kong, D., Sun, L., Hu, W., & Yang, Y. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c02453 · Cited by 7
Datta‐Mannan, A., Czeskis, B. A., Shanks, E., Yuen, E., Hall, S. D., Cruz, V. R., & Cassidy, K. C. (2025) · Clinical Pharmacology in Drug Development · doi:10.1002/cpdd.1562 · Cited by 6
Güren, A. K., Kırcalı, M. F., Köstek, O., & Demircan, N. C. (2025) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2025.2593540 · Cited by 6
Leshchenko, E. V., Chingizova, E. A., Antonov, A. S., Shlyk, N. P., Borkunov, G. V., Berdyshev, D. V., Chausova, V. E., Kirichuk, N. N., Khudyakova, Y. V., Chingizov, A. R., et al. (2024) · Marine Drugs · doi:10.3390/md22070317 · Cited by 6
Mane, B. B., Savekar, A. T., & Waghmode, S. B. (2025) · Organic Letters · doi:10.1021/acs.orglett.5c00092 · Cited by 6
OBHS impairs the viability of breast cancer via decreasing ERα and Atg13
Zhou, J., Shen, R., Zhou, H., & Huang, J. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.08.013 · Cited by 6
Exploring TMPRSS2 Drug Target to Combat Influenza and Coronavirus Infection
Baby, K., Vithalkar, M. P., Dastidar, S. G., Mukhopadhyay, C., Hamdy, R. M., Soliman, S. S. M., & Nayak, Y. (2025) · Scientifica · doi:10.1155/sci5/3687892 · Cited by 7
Zheng, D., Jiang, S. H., Qin, S., An, B., & Gao, L. (2025) · Sustainable Chemistry and Pharmacy · doi:10.1016/j.scp.2025.102046 · Cited by 5
Ahmed, N. S., El-Nakib, H. E., Ramsis, M. M., Albably, N. O., Wober, J., Weigand, J. J., Schwedtmann, K., Zierau, O., & Abadi, A. (2023) · ACS Omega · doi:10.1021/acsomega.3c01682 · Cited by 5
Lu, Y., Zhao, Z., Wang, S., Zheng, T., Chen, X., Liu, L., Zhu, Y., & Liu, W. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116897 · Cited by 5
Self-citationLuo, G., Li, X., Lin, X., Lu, X., Li, Z., & Xiang, H. (2022) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2022.106154 · Cited by 5
Olayoku, F. R., Verhoog, N. J. D., & Louw, A. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1122031 · Cited by 5
McSwiggen, D. T., Liu, H., Tan, R., Puig, S. A., Akella, L. B., Berman, R., Bretan, M., Chen, H., Darzacq, X., Ford, K., et al. (2024) · eLife · doi:10.7554/elife.93183.2 · Cited by 5
Muthukrishnan, S., Raman, C., Chandrasekaran, G., Soundhirapandi, P., Chinnappan, G., Prakasam, R., Manogar, P., & Pandiyan, J. (2025) · 3 Biotech · doi:10.1007/s13205-025-04409-z · Cited by 4
Treatment of ER-positive breast cancer with FDA-approved aromatase inhibitors
Kim, N., & Lukong, K. E. (2026) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2026.101134 · Cited by 4
Ngoc, N. T. D., Yurchenko, E. A., Trinh, P. T. H., Menchinskaya, E. S., Trang, V. T. D., Savagina, A. D., Минин, А. С., Thinh, P. D., Khánh, H. H. N., Vân, T. T. T., et al. (2024) · Regional Studies in Marine Science · doi:10.1016/j.rsma.2024.104003 · Cited by 4
Artificial Protein Crosstalk with a Molecule that Exchanges Binding Partners
Suss, O., Halfin, O., Porat, Z., Sirkis, Y. F., Motiei, L., & Margulies, D. H. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202312461 · Cited by 4
McSwiggen, D. T., Liu, H., Tan, R., Puig, S. A., Akella, L. B., Berman, R., Bretan, M., Chen, H., Darzacq, X., Ford, K., et al. (2023) · eLife · doi:10.7554/elife.93183.1 · Cited by 4
Artificial Intelligence (AI)-Assisted Treatment of Breast Cancer
Mubasshira, Rahman, M. M., Mondal, J., Parvez, M. M. H., Uddin, M. N., & Akter, L. (2026) · Springer eBooks · doi:10.1007/978-981-95-3682-5_18 · Cited by 5
Abdullaeva, S., Abdullaeva, P., Gabdrakhimova, R. A., Александровна, Н. К., Евгеньевна, Н. М., Liu, J., MIu, S., Самородов, А. В., Smolyarchuk, Е. А., Sukocheva, O. A., et al. (2025) · Current Medicinal Chemistry · doi:10.2174/0109298673345472250301052255 · Cited by 3
Naseem, M., Siddique, A., Latif, M. S., Alshammari, A. Q., Sheikh, T. A., Alshammari, A. Q., Akhtar, M. N., & Rahman, M. M. (2025) · Inorganic Chemistry Communications · doi:10.1016/j.inoche.2025.114718 · Cited by 3
Çetin, M. M., Peng, W., Unruh, D. K., Mayer, M. F., Mechref, Y. S., & Yelekçi, K. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.980479 · Cited by 3
Lee, T.-K., Kassees, K., Chen, C., Viswanadhapalli, S., Parra, K., Vadlamudi, R. K., & Ahn, J. (2024) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.4c00125 · Cited by 3
Al-Owaidi, M. F., & Ameri, M. F. A. (2023) · Research Journal of Pharmacy and Technology · doi:10.52711/0974-360x.2023.00152 · Cited by 3
Huang, H.-Y., Lin, L. Z. Y., Lu, X., & Jiang, Y. (2025) · Discover Oncology · doi:10.1007/s12672-025-02545-9 · Cited by 2
Bao, X., Yin, X., Xǔ, J., Zhu, Z., Lu, W., Cai, Y., Dai, R., Zheng, Z., Xu, W., Mei, S., et al. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.118199 · Cited by 2
Design, Synthesis, and In Vitro Mitotic Evaluation of 3‐Amino‐Isoquinolinones as Anticancer Agents
Abrams, J. N. (2022) · ChemistrySelect · doi:10.1002/slct.202202861 · Cited by 1
Dai, R., Bao, X., Liu, C., Yin, X., Zhu, Z., Zheng, Z., Wang, B., Yang, K., Wen, H., Li, W., et al. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116894 · Cited by 1
Development of Fluorescent Estrogen Receptor Ligands with pH Sensor Functionality
Hirano, T., Yasuda, D., Yamada, T., & Kagechika, H. (2025) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.c24-00685 · Cited by 1
Structural evolution progress of orally bioavailable selective estrogen receptor degraders
Zhang, J., Zhang, J., Zhao, Y. Y., Liu, Y., Sun, Y., Lei, H., & Zhai, X. (2025) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2025.118288 · Cited by 1
Stability of Steroid Hormone Receptors
Gale-Day, Z. J., & Gestwicki, J. E. (2022) · Wiley eBooks · doi:10.1002/9781119774198.ch2
A concise review on breast cancer in pregnancy
Yuvaraj, K., Govindhan, E., Francis Kevin Raj, S., Pavithra, J., & Muralidharan, P. (2023) · International Journal of Science and Research Archive · doi:10.30574/ijsra.2023.8.2.0272 · Cited by 1
Selenium Analogue of LSZ102 as a Highly Potent ER‐α Binder
Paegle, E., & Arsenyan, P. (2023) · European Journal of Organic Chemistry · doi:10.1002/ejoc.202300460
Paegle, E., Dimitrijevs, P., & Arsenyan, P. (2023) · New Journal of Chemistry · doi:10.1039/d3nj01739g
Artificial Protein Crosstalk with a Molecule that Exchanges Binding Partners
Suss, O., Halfin, O., Porat, Z., Sirkis, Y. F., Motiei, L., & Margulies, D. H. (2023) · Angewandte Chemie · doi:10.1002/ange.202312461
Jhaveri, K. L., Bellet, M., Turner, N. C., Loi, S., Bardia, A., Boni, V., Sohn, J., Neilan, T. G., Villanueva-Vázquez, R., Kabos, P., et al. (2024) · doi:10.1158/1078-0432.c.7077719
Jhaveri, K. L., Bellet, M., Turner, N. C., Loi, S., Bardia, A., Boni, V., Sohn, J., Neilan, T. G., Villanueva-Vázquez, R., Kabos, P., et al. (2024) · doi:10.1158/1078-0432.c.7077719.v1
Çetin, M. M., & GÜL, S. B. (2024) · Karadeniz Fen Bilimleri Dergisi · doi:10.31466/kfbd.1423254
Kawano, S., Fukushima, S., Nishibata, K., Gejima, R., & Miyano, S. W. (2025) · Cancers · doi:10.3390/cancers17071084
Vyas, A. J., Ramani, A., & Patel, A. I. (2025) · Asian Journal of Pharmaceutical Analysis · doi:10.52711/2231-5675.2025.00011
Chen, M., Zhang, H., Chen, S., Liang, P., Wu, Z., Gao, X., Chen, J., Wu, S., Zhang, J., & Tian, Y. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.109011
Tong, J., Wang, P., Ma, S., Li, J., Zhan, Y., Liu, M., Jin, F., Qu, G., Zheng, C., Wang, X., et al. (2026) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-026-06132-1
Peng, X., Hossain, A., Ma, P., Guo, S., Mottamal, M., Zhang, C., 郑时龙, Kang, B., & Wang, G. (2026) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2026.118956
Etessami, J. D., Valenza, C., Giachetti, P. P. M. B., Crimini, E., Ferraro, E., Marra, A., Belli, C., Minchella, I., Zagami, P., Curigliano, G., et al. (2026) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2026.2678481
Kuzminac, I. Z., Bekić, S. S., Stevanović, M. Z., Scholda, J., Kopp, F. B., Petri, E. T., Ćelić, A. S., & Sakač, M. N. (2026) · Chemical Biology & Drug Design · doi:10.1111/cbdd.70321
Kroemer, M., Lopez, M., Mansi, L., & Curtit, E. (2026) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2026.2686701
NCP07: A potent ERα CBS-targeted degrader with dual-action against ESR1 mutations in breast cancer
Liang, J., Wu, Y., Yang, L., Xu, B., Wang, D., Shu, H., Dong, C., Li, S., & Zhou, H. (2026) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2026.119113
Metadata
- Authors
- Lu, Y., & Liu, W.
- Affiliations
- Nanjing University of Chinese Medicine (CN)
- Corresponding author
- Lu, Yunlong
- Liu, Wukun
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-11-02
- Volume
- 63
- Issue
- 24
- Pages
- 15094-15114
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W3094721087
- Cited by
- 119
- References
- 178
- Citations by year
- 2026: 20 · 2025: 22 · 2024: 29 · 2023: 29 · 2022: 12 · 2021: 7
- FWCI
- 7.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Jiangsu Provincial Department of Education
- State Key Laboratory of Natural Medicines (SKLNMKF201712, SKLNMKF201808)
- Six Talent Peaks Project in Jiangsu Province (SWYY-069)
- National Natural Science Foundation of China (81703337)
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- State Key Laboratory of Coordination Chemistry, Nanjing University
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Oncology › Advanced Breast Cancer Therapies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Keywords
- selective estrogen receptor degrader, estrogen receptor-positive breast cancer, endocrine therapy resistance, fulvestrant, aromatase inhibitors, selective estrogen receptor modulators, drug resistance mechanisms
- MeSH terms
- Fulvestrant, Breast Neoplasms, Clinical Trials as Topic, Female, Humans, Steroids, Structure-Activity Relationship, Signal Transduction, Drug Resistance, Neoplasm, Selective Estrogen Receptor Modulators, Aromatase Inhibitors, Estrogen Receptor alpha
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review