The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Design, Synthesis, and Evaluation of Orally Bioavailable Quinoline–Indole Derivatives as Innovative Multitarget-Directed Ligands: Promotion of Cell Proliferation in the Adult Murine Hippocampus for the Treatment of Alzheimer’s Disease
Abstract
A novel series of quinoline-indole derivatives were synthesized and evaluated as multitarget-directed ligands for the treatment of Alzheimer's disease (AD). Biological evaluation revealed that the derivatives had multifunctional profiles including antioxidant effects, blood-brain barrier (BBB) penetration, biometal chelation, Aβ aggregation modulation, neurotrophic and neuroprotective properties. Moreover, several representative target derivatives demonstrated hippocampal cell proliferation in living adult mice by intracerebroventricular (icv) injection or oral administration. Further drug-like property analysis demonstrated that the optimized compound, 8d (WI-1758), had liver microsomal metabolic stability, was well tolerated (>2000 mg/kg), and had a rational pharmacokinetic profile, as well as an oral bioavailability of 14.1% and a positive log BB (-0.19) to cross the BBB in vivo. Pharmacodynamics studies demonstrated that chronic oral administration of 8d·HCl substantially ameliorated the cognitive and spatial memory deficits in APP/PS1 AD mice and noticeably reduced overall cerebral β-amyloid deposits.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Interestingly, among those small molecules, indole-based melatonin-N-benzylamine hybrids, have been proven to effectively promote the development of neural stem cells into neuronal phenotypes.128”
From From combinations to multitarget-directed ligands: A continuum in Alzheimer’s disease polypharmacology (2021) · cites this paper as [128]
Citations
Cites
1 retracted
Ranković, Z. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b01469 · Cited by 97
RetractedAlzheimer’s disease: Clinical trials and drug development
Mangialasche, F., Solomon, A., Winblad, B., Mecocci, P., & Kivipelto, M. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70119-8 · Cited by 1,217
High throughput artificial membrane permeability assay for blood–brain barrier
Di, L., Kerns, E. H., Fan, K., McConnell, O. J., & Carter, G. T. (2003) · European Journal of Medicinal Chemistry · doi:10.1016/s0223-5234(03)00012-6 · Cited by 1,195
(2016) · London School of Economics and Political Science Research Online (London School of Economics and Political Science) · Cited by 874
Adlard, P. A., Cherny, R. A., Finkelstein, D. I., Gautier, E., Robb, E., Cortes, M., Volitakis, I., Liu, X., Smith, J. P., Perez, K., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.018 · Cited by 672
Fluoxetine targets early progenitor cells in the adult brain
Encinas, J. M., Vaahtokari, A., & Enikolopov, G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601992103 · Cited by 637
CNS Drug Design: Balancing Physicochemical Properties for Optimal Brain Exposure
Ranković, Z. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm501535r · Cited by 592
A regenerative approach to the treatment of multiple sclerosis
Deshmukh, V. A., Tardif, V., Lyssiotis, C. A., Green, C. C., Kerman, B., Kim, H. J., Padmanabhan, K., Swoboda, J. G., Ahmad, I., Kondo, T., et al. (2013) · Nature · doi:10.1038/nature12647 · Cited by 531
Biological metals and metal-targeting compounds in major neurodegenerative diseases
Barnham, K. J., & Bush, A. I. (2014) · Chem. Soc. Rev. · doi:10.1039/c4cs00138a · Cited by 497
Wohnsland, F., & Faller, B. (2001) · Journal of Medicinal Chemistry · doi:10.1021/jm001020e · Cited by 495
Cited by
Sorted by citations
Savelieff, M. G., Nam, G., Kang, J., Lee, H. J., Lee, M., & Lim, M. H. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00138 · Cited by 612
Quinoline and quinolone dimers and their biological activities: An overview
Chu, X., Wang, C., Liu, W., Liang, L., Gong, K., Zhao, C., & Sun, K. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.10.035 · Cited by 251
Biological Effects of Quinolones: A Family of Broad-Spectrum Antimicrobial Agents
Millanao, A. R., Mora, A. Y., Villagra, N. A., Bucarey, S. A., & Hidalgo, A. A. (2021) · Molecules · doi:10.3390/molecules26237153 · Cited by 230
Multi-target design strategies for the improved treatment of Alzheimer's disease
Zhang, P., Xu, S., Zhu, Z., & Xu, J. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.05.020 · Cited by 221
Albertini, C., Salerno, A., de Sena Murteira Pinheiro, P., & Bolognesi, M. L. (2021) · Medicinal Research Reviews · doi:10.1002/med.21699 · Cited by 179
Insights of 8-hydroxyquinolines: A novel target in medicinal chemistry
Gupta, R., Luxami, V., & Paul, K. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2021.104633 · Cited by 159
Recent advances in the synthetic and medicinal perspective of quinolones: A review
Dhiman, P., Arora, N. R., Thanikachalam, P. V., & Monga, V. (2019) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2019.103291 · Cited by 154
Alzheimer's disease: Updated multi-targets therapeutics are in clinical and in progress
Sang, Z., Wang, K., Dong, J., & Tang, L. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114464 · Cited by 127
Multitarget Therapeutic Strategies for Alzheimer’s Disease: Review on Emerging Target Combinations
Maramai, S., Benchekroun, M., Gabr, M. T., & Yahiaoui, S. (2020) · BioMed Research International · doi:10.1155/2020/5120230 · Cited by 121
Sang, Z., Wang, K., Shi, J., Cheng, X., Zhu, G., Wei, R., Ma, Q., Yu, L., Zhao, Y., Tan, Z., et al. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.111958 · Cited by 102
Recent Advances in the Synthesis and Biological Activity of 8-Hydroxyquinolines
Saadeh, H. A., Sweidan, K., & Mubarak, M. S. (2020) · Molecules · doi:10.3390/molecules25184321 · Cited by 96
Sang, Z., Wang, K., Shi, J., Liu, W., Cheng, X., Zhu, G., Wang, Y., Zhao, Y., Qiao, Z., Wu, A., et al. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112180 · Cited by 77
Sales, T. A., Prandi, I. G., de Castro, A. A., Leal, D. H. S., da Cunha, E. F. F., Kuča, K., & Ramalho, T. C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081829 · Cited by 73
Redox-Active Metal Ions and Amyloid-Degrading Enzymes in Alzheimer’s Disease
Kim, N., & Lee, H. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147697 · Cited by 67
Cai, P., Fang, S., Yang, H., Yang, X., Liu, Q., Kong, L., & Wang, X. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.08.005 · Cited by 59
Self-citationKou, X., Song, L., Wang, Y., Yu, Q., Ju, H., Yang, A., & Shen, R. (2019) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2019.126927 · Cited by 59
Current Pharmaceutical Aspects of Synthetic Quinoline Derivatives
Tabassum, R., Ashfaq, M. H., & Oku, H. (2020) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557520999201214234735 · Cited by 54
Liu, Z., Zhang, B., Xia, S., Fang, L., & Gou, S.-H. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112997 · Cited by 48
Pérez-Areales, F. J., Turcu, A. L., Barniol‐Xicota, M., Pont, C., Pivetta, D., Espargaró, A., Bartolini, M., Simone, A. D., Andrisano, V., Pérez, B., et al. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.07.051 · Cited by 44
Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6
Pérez-Areales, F. J., Garrido, M., Aso, E., Bartolini, M., Simone, A. D., Espargaró, A., Ginex, T., Sabaté, R., Pérez, B., Andrisano, V., et al. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00528 · Cited by 43
Wu, J., Kou, X., Ju, H., Zhang, H., Yang, A., & Shen, R. (2021) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2021.128316 · Cited by 42
Wang, D., Hu, M. S., Li, X., Zhang, D., Chen, C., Fu, J., Shao, S., Shi, G., Zhou, Y., Wu, S., et al. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.02.053 · Cited by 41
Self-citationYan, J., Pang, Y., Zhuang, J., Lin, H., Zhang, Q., Han, L., Ke, P., Zhuang, J., & Huang, X. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00106 · Cited by 40
Zhou, L., Liang, Y.-F., Huang, Y., Yang, G., Zheng, L., Sun, J., Li, Y., Zhu, F., Qian, H., Wang, R., et al. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113426 · Cited by 39
Chen, H., Mi, J., Li, S., Liu, Z., Yang, J. L., Chen, R., Wang, Y., Ban, Y., Zhou, Y. M., Dong, W., et al. (2023) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2023.2169682 · Cited by 36
Quinoline Quest: Kynurenic Acid Strategies for Next-Generation Therapeutics via Rational Drug Design
Tanaka, M., Szatmári, I., & Vécsei, L. (2025) · Pharmaceuticals · doi:10.3390/ph18050607 · Cited by 37
Leuci, R., Brunetti, L., Laghezza, A., Loiodice, F., Tortorella, P., & Piemontese, L. (2020) · Applied Sciences · doi:10.3390/app10124118 · Cited by 35
Metals and Metal-Nanoparticles in Human Pathologies: From Exposure to Therapy
Lachowicz, J. I., Lecca, L. I., Meloni, F., & Campagna, M. (2021) · Molecules · doi:10.3390/molecules26216639 · Cited by 34
Hu, J., Huang, Y.-D., Pan, T., Zhang, T., Su, T., Li, X., Luo, H., & Huang, L. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00376 · Cited by 33
Self-citationLiao, Q., Li, Q., Zhao, Y., Jiang, P. H., Yan, Y., Sun, H., Liu, W., Feng, F., & Qu, W. (2020) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2020.103844 · Cited by 33
Umar, M., Rehman, Y., Ambreen, S., Mumtaz, S. M., Shaququzzaman, M., Alam, M. M., & Ali, R. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102298 · Cited by 33
Discovery of novel butyrylcholinesterase inhibitors for treating Alzheimer's disease
Sang, Z., Huang, S., Tan, W., Ban, Y., Wang, K., Fan, Y., Chen, H., Zhang, Q., Liang, C., Mi, J., et al. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.02.030 · Cited by 30
SAR studies of quinoline and derivatives as potential treatments for Alzheimer’s disease
Li, Z., Yin, L., Zhao, D., Jin, L., Sun, Y.-J., & Tan, C. (2022) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2022.104502 · Cited by 29
Zhou, Y., Lü, X., Yang, H., Chen, Y., Wang, F., Li, J., Tang, Z., Cheng, X.-F., Yang, Y., Xu, L., et al. (2019) · Molecules · doi:10.3390/molecules24234217 · Cited by 27
Mohasin, M., Alam, M. Z., Ullah, Q., Ahmad, A., Rahaman, P. F., & Khan, S. A. (2023) · Polycyclic aromatic compounds · doi:10.1080/10406638.2023.2270118 · Cited by 26
Alım, Z., Şirinzade, H., Kılınç, N., Dilek, E., & Süzen, S. (2024) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2024.138276 · Cited by 26
Huang, H., Bow, Y., Wang, C., Chen, Y., Fu, P.-R., Chang, K.-F., Wang, T.-W., Tseng, C.-H., Chen, Y., & Chiu, C. (2020) · Cancers · doi:10.3390/cancers12051348 · Cited by 26
Xu, H., & Li, T.-Z. (2022) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557522666220330123538 · Cited by 26
Hu, J., An, B., Pan, T., Li, Z., Huang, L., & Li, X. (2018) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2018.10.022 · Cited by 26
Self-citationBao, L., Liu, Y., Peng, J., Wang, Y., Dong, J., & Xu, X. (2021) · Organic Letters · doi:10.1021/acs.orglett.1c03693 · Cited by 25
Chen, Y., Wu, B., Hao, Y., Liu, Y., Zhang, Z., Tian, C., Ning, X., Guo, Y. Q., Liu, J., & Wang, X. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.03.044 · Cited by 21
Antioxidants in anti‐Alzheimer's disease drug discovery
Guo, J., Zhu, Y., Zhi, J., Lou, Q., Bai, R., & He, Y. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102707 · Cited by 21
Singh, G., Kumar, S., Panda, S. R., Kumar, P., Rai, S., Verma, H., Singh, Y. P., Kumar, S., Srikrishna, S., Naidu, V. G. M., et al. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00130 · Cited by 19
Hamuľaková, S., Kudlicková, Z., Janovec, L., Mezencev, R., Deckner, Z. J., Chernoff, Y. O., Janočková, J., Ihnatova, V., Bzonek, P., Novakova, N., et al. (2021) · Future Medicinal Chemistry · doi:10.4155/fmc-2020-0184 · Cited by 19
Pont, C., Ginex, T., Griñán‐Ferré, C., Scheiner, M., Mattellone, A., Martínez, N., Arce, E. M., Soriano-Fernández, Y., Naldi, M., Simone, A. D., et al. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113779 · Cited by 20
Tabassum, R., Ashfaq, M. H., Tahir, T., & Oku, H. (2022) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2022.134058 · Cited by 18
Nanotechnology‐empowered therapeutics targeting neurodegenerative diseases
Wang, Z., Gonzalez, K. M., Cordova, L. E., & Lu, J. (2023) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1907 · Cited by 18
Self-citationRecent Advancements in the Treatment of Alzheimer’s Disease: A Multitarget-directed Ligand Approach
Kumar, S., Mahajan, A. T., Ambatwar, R., & Khatik, G. L. (2023) · Current Medicinal Chemistry · doi:10.2174/0109298673264076230921065945 · Cited by 17
Tao, L., Wei, Y., & Shi, M. J. (2020) · Organic Chemistry Frontiers · doi:10.1039/d0qo00878h · Cited by 15
Farouki, K. E., Kacem, M., Dib, M., Ouchetto, H., Hafid, A., & Khouili, M. (2023) · Current Organocatalysis · doi:10.2174/0122133372264682231019101634 · Cited by 15
Discovery of a promising agent IQZ23 for the treatment of obesity and related metabolic disorders
Rao, Y., Zhao, X. D., Hu, Y., Li, C., Xu, Y., Song, Q., Yu, H., Song, B.-B., Chen, S.-B., Li, Q., et al. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112172 · Cited by 15
Wang, Z., Cao, M., Xiang, H., Wang, W., Feng, X., & Yang, X. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00409 · Cited by 14
Self-citationSteroid–Quinoline Hybrids for Disruption and Reversion of Protein Aggregation Processes
Albuquerque, H. M. T., da Silva, R. N., Pereira, M., Maia, A. F., Guieu, S., Soares, A. R., Santos, C. M. M., Vieira, S. I., & Silva, A. M. S. (2022) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.1c00604 · Cited by 14
Novel Multi-Target Agents Based on the Privileged Structure of 4-Hydroxy-2-quinolinone
Kostopoulou, I., Tzani, A., Chronaki, K., Prousis, K. C., Pontiki, E. A., Hadjipavlou‐Litina, D., & Detsi, A. (2023) · Molecules · doi:10.3390/molecules29010190 · Cited by 12
Recent Advances in Transition Metal Free Synthetic Protocols for Quinoline Derivatives
Tabassum, R., Ashfaq, M. H., & Oku, H. (2020) · Current Organic Chemistry · doi:10.2174/1385272824999200616122557 · Cited by 12
Liu, Y., Cong, L., Han, C., Li, B., & Dai, R. (2020) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557520666201127104539 · Cited by 10
Shinde, A. D., Nandurkar, Y. M., Bhalekar, S., Walunj, Y., Ugale, S. R., Ahmad, I., Patel, H., Chavan, A., & Mhaske, P. C. (2023) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2023.2217922 · Cited by 8
Fluorescent sterol probes for intracellular transport, imaging, and therapeutics
Mansuri, S., Mukherjee, T., & Kanvah, S. (2022) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2022.102222 · Cited by 7
Jing, L., Wei, W., Meng, B., Chantegreil, F., Nachon, F., Martı́nez, A., Wu, G., Zhao, H., Song, Y., Kang, D., et al. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2023.106465 · Cited by 7
Effect of a newly synthesized quinoline-based compound (PPQ-8) on murine schistosomiasis mansoni
Taman, A. I., Alhusseiny, S. M., Saleh, N. E., Youssef, M., Mansour, B., Massoud, M. A. M., & El-Beshbishi, S. N. (2020) · Journal of Helminthology · doi:10.1017/s0022149x2000005x · Cited by 7
Mekheimer, R. A., Allam, S. M. R., Al‐Sheikh, M. A., Medrasi, H. Y., Abd‐Elmonem, M., & Sadek, K. U. (2025) · RSC Advances · doi:10.1039/d5ra00779h · Cited by 6
Shan, L., Li, H., Zheng, W., Wang, X., Wang, X., & Hu, Y. (2022) · Organic Letters · doi:10.1021/acs.orglett.2c03565 · Cited by 6
Wolfberry extracts inhibit Aβ1-42 aggregation and rescue memory loss of AD drosophila
Li, C., & Yang, J. (2019) · Food Science and Human Wellness · doi:10.1016/j.fshw.2019.12.007 · Cited by 6
Borisova, M. A., Ryabukhin, D. S., Ivanov, A. Y., Boyarskaya, I. А., Spiridonova, D. V., Kompanets, M. O., & Vasilyev, A. V. (2021) · Chemistry of Heterocyclic Compounds · doi:10.1007/s10593-021-03015-0 · Cited by 6
Fan, M., Song, X., Lu, L., He, J., Shen, Y., Zhang, C., Wang, F., & Xie, Y. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116786 · Cited by 5
Skoptsova, A. A., Geronikaki, A. A., Novichikhina, N. P., Sulimov, A. V., Ilin, I. S., Sulimov, V. B., Bykov, G. A., Podoplelova, N. A., Pyankov, O. V., & Shikhaliev, K. S. (2024) · Molecules · doi:10.3390/molecules29020373 · Cited by 5
Wang, W., Pan, T., Su, R., Chen, M., Xiong, W., Xu, C., & Huang, L. (2024) · Frontiers in Chemistry · doi:10.3389/fchem.2024.1374930 · Cited by 5
Self-citationTabassum, R., Ashfaq, M. H., & Oku, H. (2020) · Journal of Heterocyclic Chemistry · doi:10.1002/jhet.4193 · Cited by 5
8-Hydroxyquinoline Derivatives as Drug Candidates for the Treatment of Alzheimer's Disease
Bartolomeu, P. F., Fortes, I. S., Zimmer, A. R., Lopes, M. S., & de Andrade, S. F. (2025) · Current Medicinal Chemistry · doi:10.2174/0109298673409645250823055140 · Cited by 4
Viveka, T. L., Angajala, G., Aruna, V., Nakka, M., & Aparna, Y. (2024) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2024.137482 · Cited by 4
Sharma, P., & Jha, N. S. (2023) · Journal of Molecular Recognition · doi:10.1002/jmr.3041 · Cited by 4
Vogt, A. G., de Oliveira, R. L., Voss, G. T., Blödorn, G. B., Alves, D. A. C., Wilhelm, E. A., & Luchese, C. (2022) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2022.173357 · Cited by 4
Yadav, M. B., & Jeong, Y. T. (2022) · Tetrahedron Letters · doi:10.1016/j.tetlet.2022.154158 · Cited by 4
Tabassum, R., Ashfaq, M. H., & Oku, H. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e05035 · Cited by 4
A turn on fluorescent probe for Zn2+ based on Quinoline with flexible chelating group
Zheng, D., Huang, R., & Lan, H. (2025) · Results in Chemistry · doi:10.1016/j.rechem.2025.102523 · Cited by 3
Recent Advances in the Quest for Treatment and Management of Alzheimer and Other Dementia
Tanwir, S. E., & Kumar, A. (2019) · Open Journal of Medicinal Chemistry · doi:10.4236/ojmc.2019.91001 · Cited by 3
Discovery of small molecules for the treatment of Alzheimer’s disease
Rao, P. P. N., Pham, A. T., & Shakeri, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818349-6.00011-x · Cited by 3
Lü, X., Liu, Y., Qin, N., Yang, H., Qiao, Y., Jiang, X., Chen, Y., Feng, F., Liu, W., Zhou, Y., et al. (2021) · Future Medicinal Chemistry · doi:10.4155/fmc-2021-0039 · Cited by 3
Söderberg, B. C. G., & Berkowitz, W. F. (2022) · Organic reactions · doi:10.1002/0471264180.or111.02 · Cited by 3
Prachayasittikul, V., Pingaew, R., Prachayasittikul, S., & Prachayasittikul, V. (2022) · Heterocycles · doi:10.3987/rev-22-sr(r)6 · Cited by 2
Fathalla, E. M., El‐Faham, A., Soliman, S. M., Barakat, A., Haukka, M., Ramadan, S., Abu-Youssef, M. A. M., M.A.Badr, A., & Yousri, A. (2026) · Inorganica Chimica Acta · doi:10.1016/j.ica.2026.123269 · Cited by 1
Unveiling the pathogenesis and therapeutic strategies of Alzheimer’s disease through cuproptosis
Xu, S., Mu, J., Wang, Z., Yang, J., Tian, D., Shi, T., Lan, J., He, P., Hao, Z., Fu, Y., et al. (2026) · BioMetals · doi:10.1007/s10534-026-00835-5 · Cited by 1
Self-citationAlzheimer's disease therapeutics
Sang, Z., & Huang, L. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-18611-0.00031-0 · Cited by 1
Self-citationMurie, V. E. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.60.2020.tde-22092021-090511
Base-promoted tandem synthesis of 2-azaaryl indoline
Chen, S., Tan, J., Wu, H., Zhao, Q., & Shang, Y. (2023) · Organic & Biomolecular Chemistry · doi:10.1039/d3ob01444d
A Brief Review of the Medicinally Important Indole Derivatives
Dube, P. N., Chaudhari, S., Thakare, P. Y., Yadav, S., & Kore, Y. S. (2023) · Journal Of Advanced Zoology · doi:10.53555/jaz.v44is7.3027
Edukondalu, P., Ravi, N., Matta, R., Kishan, G., & Kumar, K. S. (2025) · Asian Journal of Organic Chemistry · doi:10.1002/ajoc.202400702
Indole-Derived Compounds as Redox-Modulators: Antioxidant Mechanisms in Neuronal Protection
Singh, A. A., Arukha, A. P., & Song, M. (2026) · Molecules · doi:10.3390/molecules31132323
Manahelohe, G. M., Li, C.-S., Shi, C.-X., Chen, X., Li, F., Wang, Y., Hao, G., & Zhang, M. (2026) · Advanced Agrochem · doi:10.1016/j.aac.2026.09.003
Shanmugavel, B., & Vijayakumar, V. (2026) · Scientific Reports · doi:10.1038/s41598-026-65282-1
Piplani, M., Thakur, S., Kumar, P., Garg, S. S., Goyal, A., & Goyal, P. (2026) · Biomedical & Pharmacology Journal · doi:10.13005/bpj/3483
BindingDB (2023) · UC San Diego · doi:10.7270/q2fb56xk
BindingDB (2021) · UC San Diego · doi:10.7270/q2g1643k
BindingDB (2022) · UC San Diego · doi:10.7270/q23n2733
Metadata
- Authors
- Wang, Z., Hu, J., Yang, X., Feng, X., Li, X., Huang, L., & Chan, A. S. C.
- Affiliations
- Sun Yat-sen University (CN)
- Hunan Normal University (CN)
- Corresponding author
- Li, Xingshu
- Huang, Ling
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-02-08
- Volume
- 61
- Issue
- 5
- Pages
- 1871-1894
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W2786700855
- Cited by
- 91
- References
- 49
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 7 · 2023: 12 · 2022: 12 · 2021: 11 · 2020: 19 · 2019: 13 · 2018: 5
- FWCI
- 9.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education of the People's Republic of China (15ykpy04)
- National Natural Science Foundation of China (21302235, 21772241)
- Natural Science Foundation of Guangdong Province (2014A030313124)
- Guangzhou Municipality (201610010111)
- Government Province (2015TQ01R244)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
- Physical Sciences › Chemistry › Organic Chemistry › Heterocyclic Compound Synthesis and Bioactivity
- Keywords
- multi-target-directed ligands, Alzheimer's disease, oral bioavailability, blood-brain barrier penetration, amyloid-beta aggregation, antioxidant activity, neuroprotection, neurotrophic activity, hippocampal cell proliferation, cognitive impairment, spatial memory, APP/PS1 mice, drug-likeness, pharmacokinetics, pharmacodynamics
- MeSH terms
- Alzheimer Disease, Animals, Blood-Brain Barrier, Hippocampus, Humans, Indoles, Ligands, Memory Disorders, Quinolines, Drug Design, Amyloid beta-Peptides, Cell Proliferation, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review