The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.
Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry
Open accessAbstract
The urea functionality is inherent to numerous bioactive compounds, including a variety of clinically approved therapies. Urea containing compounds are increasingly used in medicinal chemistry and drug design in order to establish key drug-target interactions and fine-tune crucial drug-like properties. In this perspective, we highlight physicochemical and conformational properties of urea derivatives. We provide outlines of traditional reagents and chemical procedures for the preparation of ureas. Also, we discuss newly developed methodologies mainly aimed at overcoming safety issues associated with traditional synthesis. Finally, we provide a broad overview of urea-based medicinally relevant compounds, ranging from approved drugs to recent medicinal chemistry developments.
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Metadata
- Authors
- Ghosh, A. K., & Brindisi, M.
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-12-02
- Volume
- 63
- Issue
- 6
- Pages
- 2751-2788
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W2991251974
- Cited by
- 401
- References
- 135
- FWCI
- 10.36
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
