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Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF

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Wan, Paul T.C, Garnett, Mathew J, Roe, S.Mark, Lee, Sharlene, Niculescu-Duvaz, Dan, Good, Valerie M, Project, Cancer Genome, Jones, C.Michael, Marshall, Christopher J, Springer, Caroline J, Barford, David, Marais, Richard·2004·Cell

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Citations

Cites

  • Mutations of the BRAF gene in human cancer

    Davies, H., Bignell, G. R., Cox, C., Stephens, P., Edkins, S., Clegg, S., Teague, J., Woffendin, H., Garnett, M. J., Bottomley, W., et al. (2002) · Nature · doi:10.1038/nature00766 · Cited by 10,674

    Self-citation
  • RAS oncogenes: the first 30 years

    Malumbres, M., & Barbacid, M. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1097 · Cited by 1,902 · cited 2×

    “Approximately 15% of human cancers have activating RAS mutationsSummary (Malumbres and Barbacid, 2003), and recently mutations in B-RAF were identified in a large-scale screenOver 30 mutations of the B-RAF gene associated with for genes mutated in human cancer (Davies et al., 2002).human cancers…”
    Background
  • RAF/RAS oncogenes and mismatch-repair status

    Rajagopalan, H., Bardelli, A., Lengauer, C., Kinzler, K. W., Vogelstein, B., & Velculescu, V. E. (2002) · Nature · doi:10.1038/418934a · Cited by 1,224 · cited 1×

    “Here of malignant melanomas and occur with moderate towe show that of 22 B-RAF mutants analyzed, 18 have high frequency in colorectal (Rajagopalan et al., 2002),elevated kinase activity and signal to ERK in vivo.”
    Background

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Metadata

Authors
Wan, P. T. C., Garnett, M. J., Roe, S. M., Lee, S., Niculescu-Duvaz, D., Good, V. M., Project, C. G., Jones, C. M., Marshall, C. J., Springer, C. J., Barford, D., & Marais, R.
Venue
Cell
Publisher
Elsevier BV
Published
2004-03
Volume
116
Issue
6
Pages
855-867
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2124662474
Cited by
2,808
References
3
FWCI
33.24
Type
journal article
Language
en
Open access
bronze
Licence

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CoChat. (2026). Citation check: Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF. https://app.cochat.ai/papers/10.1016/s0092-8674(04)00215-6
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Wan, P. T. C., Garnett, M. J., Roe, S. M., Lee, S., Niculescu-Duvaz, D., Good, V. M., Project, C. G., Jones, C. M., Marshall, C. J., Springer, C. J., Barford, D., & Marais, R. (2004). Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF. Cell. https://doi.org/10.1016/s0092-8674(04)00215-6

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