The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF
Open accessOverview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mutations of the BRAF gene in human cancer
Davies, H., Bignell, G. R., Cox, C., Stephens, P., Edkins, S., Clegg, S., Teague, J., Woffendin, H., Garnett, M. J., Bottomley, W., et al. (2002) · Nature · doi:10.1038/nature00766 · Cited by 10,674
Self-citationRAS oncogenes: the first 30 years
Malumbres, M., & Barbacid, M. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1097 · Cited by 1,902 · cited 2×
“Approximately 15% of human cancers have activating RAS mutationsSummary (Malumbres and Barbacid, 2003), and recently mutations in B-RAF were identified in a large-scale screenOver 30 mutations of the B-RAF gene associated with for genes mutated in human cancer (Davies et al., 2002).human cancers…”
BackgroundRAF/RAS oncogenes and mismatch-repair status
Rajagopalan, H., Bardelli, A., Lengauer, C., Kinzler, K. W., Vogelstein, B., & Velculescu, V. E. (2002) · Nature · doi:10.1038/418934a · Cited by 1,224 · cited 1×
“Here of malignant melanomas and occur with moderate towe show that of 22 B-RAF mutants analyzed, 18 have high frequency in colorectal (Rajagopalan et al., 2002),elevated kinase activity and signal to ERK in vivo.”
Background
Research works printed but not linked: 43
- Avruch, 2001, Ras activation of the Raf kinase, Recent Prog. Horm. Res., 56, 127, 10.1210/rp.56.1.127 · DOI · Paper page
- Azam, 2003, Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL, Cell, 112, 831, 10.1016/S0092-8674(03)00190-9 · DOI · Paper page
- Bankston, 2002, A scaleable Synthesis of BAY 43–9006, Organic Process Res. & Dev., 6, 777, 10.1021/op020205n · DOI
- Blagosklonny, 2002, Hsp-90-associated oncoproteins, Leukemia, 16, 455, 10.1038/sj.leu.2402415 · DOI · Paper page
- Brose, 2002, BRAF and RAS mutations in human lung cancer and melanoma, Cancer Res., 62, 6997
- Brunger, 1998, Crystallography & NMR system, Acta Crystallogr. D Biol. Crystallogr., 54, 905, 10.1107/S0907444998003254 · DOI · Paper page
- CCP4, 1991, The CCP4 (Collaborative Computational Project Number 4) Suite, Acta Cryst D, 50, 760
- Chong, 2001, Positive and negative regulation of Raf kinase activity and function by phosphorylation, EMBO J., 20, 3716, 10.1093/emboj/20.14.3716 · DOI · Paper page
- Cohen, 2003, Lack of BRAF mutation in primary uveal melanoma, Invest. Ophthalmol. Vis. Sci., 44, 2876, 10.1167/iovs.02-1329 · DOI
- Dent, 1989, A whole-mount immunocytochemical analysis of the expression of the intermediate filament protein vimentin in Xenopus, Development, 105, 61, 10.1242/dev.105.1.61 · DOI · Paper page
- Fabian, 1993, Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase, Mol. Cell. Biol., 13, 7170, 10.1128/MCB.13.11.7170 · DOI · Paper page
- Farrar, 1996, Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization, Nature., 383, 178, 10.1038/383178a0 · DOI · Paper page
- Glover, 1995, Election of activating mutations of c-fms in FDC-P1 cells, Oncogene, 11, 1347
- Grant, 1998, Kinetic analyses of mutations in the glycine-rich loop of cAMP-dependent protein kinase, Biochemistry, 37, 7708, 10.1021/bi972987w · DOI
- Hubbard, 1994, Crystal structure of the tyrosine kinase domain of the human insulin receptor, Nature, 372, 746, 10.1038/372746a0 · DOI · Paper page
- Ikenoue, 2003, Functional analysis of mutations within the kinase activation segment of B-Raf in human colorectal tumors, Cancer Res., 63, 8132
- Johnson, 1996, Active and inactive protein kinases, Cell, 85, 149, 10.1016/S0092-8674(00)81092-2 · DOI · Paper page
- Jones, 1991, Improved methods for building protein models in electron density maps and the location of errors in these models, Acta Crystallogr. A, 47, 110, 10.1107/S0108767390010224 · DOI · Paper page
- Jones, 1996, Bone morphogenetic protein-4 (BMP-4) acts during gastrula stages to cause ventralization of Xenopus embryos, Development, 122, 1545, 10.1242/dev.122.5.1545 · DOI
- Kitayama, 1995, Constitutively activating mutations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell lines, Blood, 85, 790, 10.1182/blood.V85.3.790.bloodjournal853790 · DOI · Paper page
- Kolch, 2000, Meaningful relationships, Biochem. J., 351, 289, 10.1042/0264-6021:3510289 · doi:10.1042/0264-6021:3510289 · Paper page
- Lowinger, 2002, Design and discovery of small molecules targeting raf-1 kinase, Curr. Pharm. Des., 8, 2269, 10.2174/1381612023393125 · DOI
- Luo, 1996, Oligomerization activates c-Raf-1 through a Ras-dependent mechanism, Nature, 383, 181, 10.1038/383181a0 · DOI · Paper page
- Lyons, 2001, Discovery of a novel Raf kinase inhibitor, Endocr. Relat. Cancer, 8, 219, 10.1677/erc.0.0080219 · DOI · Paper page
- MacNicol, 2000, Disruption of the 14–3-3 binding site within the B-Raf kinase domain uncouples catalytic activity from PC12 cell differentiation, J. Biol. Chem., 275, 3803, 10.1074/jbc.275.6.3803 · DOI
- Manning, 2002, The protein kinase complement of the human genome, Science, 298, 1912, 10.1126/science.1075762 · DOI · Paper page
- Marais, 1997, Differential regulation of Raf-1, A-Raf and B-Raf by oncogenic Ras and tyrosine kinases, J. Biol. Chem., 272, 4378, 10.1074/jbc.272.7.4378 · DOI · Paper page
- Marais, 1998, Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C, Science, 280, 109, 10.1126/science.280.5360.109 · DOI · Paper page
- Mason, 1999, Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation, EMBO J., 18, 2137, 10.1093/emboj/18.8.2137 · DOI · Paper page
- Michaud, 1995, 14–3-3 is not essential for Raf-1 function, Mol. Cell. Biol., 15, 3390, 10.1128/MCB.15.6.3390 · DOI · Paper page
- Morrison, 2001, Ksr, J. Cell Sci., 114, 1609, 10.1242/jcs.114.9.1609 · DOI · Paper page
- Morrison, 1997, The complexity of Raf-1 regulation, Curr. Opin. Cell Biol., 9, 174, 10.1016/S0955-0674(97)80060-9 · DOI · Paper page
- Nagar, 2002, Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571), Cancer Res., 62, 4236
- Pargellis, 2002, Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site, Nat. Struct. Biol., 9, 268, 10.1038/nsb770 · DOI · Paper page
- Rapp, 1983, Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus, Proc. Natl. Acad. Sci. USA, 80, 4218, 10.1073/pnas.80.14.4218 · DOI · Paper page
- Robinson, 1997, Mitogen-activated protein kinase pathways, Curr. Opin. Cell Biol., 9, 180, 10.1016/S0955-0674(97)80061-0 · DOI · Paper page
- Schindler, 2000, Structural mechanism for STI-571 inhibition of abelson tyrosine kinase, Science, 289, 1938, 10.1126/science.289.5486.1938 · DOI · Paper page
- Singer, 2003, Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma, J. Natl. Cancer Inst., 95, 484, 10.1093/jnci/95.6.484 · DOI · Paper page
- Stancato, 1993, Raf exists in a native heterocomplex with hsp90 and p50 that can be reconstituted in a cell-free system, J. Biol. Chem., 268, 21711, 10.1016/S0021-9258(20)80600-0 · DOI · Paper page
- Weber, 2001, Active Ras induces heterodimerization of cRaf and BRaf, Cancer Res., 61, 3595
- Yang, 2002, Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP, Nat. Struct. Biol., 9, 940, 10.1038/nsb870 · DOI · Paper page
- Yuen, 2002, Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia, Cancer Res., 62, 6451
- Zhang, 2000, Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601, EMBO J., 19, 5429, 10.1093/emboj/19.20.5429 · DOI · Paper page
Cited by
Pao, W., Miller, V., Zakowski, M., Doherty, J., Politi, K., Sarkaria, I., Singh, B., Heelan, R., Rusch, V., Fulton, L., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405220101 · Cited by 4,338
Inhibition of Mutated, Activated BRAF in Metastatic Melanoma
Flaherty, K. T., Puzanov, I., Kim, K. B., Ribas, A., McArthur, G. A., Sosman, J. A., O'Dwyer, P. J., Lee, R. J., Grippo, J. F., Nolop, K., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1002011 · Cited by 3,103
MAP kinase signalling pathways in cancer
Dhillon, A. S., Hagan, S., Rath, O., & Kolch, W. (2007) · Oncogene · doi:10.1038/sj.onc.1210421 · Cited by 2,995
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
Roberts, P. J., & Der, C. J. (2007) · Oncogene · doi:10.1038/sj.onc.1210422 · Cited by 2,788
Pathological roles of MAPK signaling pathways in human diseases
Kim, E. K., & Choi, E.-J. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.12.009 · Cited by 2,472
Metadata
- Authors
- Wan, P. T. C., Garnett, M. J., Roe, S. M., Lee, S., Niculescu-Duvaz, D., Good, V. M., Project, C. G., Jones, C. M., Marshall, C. J., Springer, C. J., Barford, D., & Marais, R.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2004-03
- Volume
- 116
- Issue
- 6
- Pages
- 855-867
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2124662474
- Cited by
- 2,808
- References
- 3
- FWCI
- 33.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 3425 d)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF. https://app.cochat.ai/papers/10.1016/s0092-8674(04)00215-6
- The paper
- Wan, P. T. C., Garnett, M. J., Roe, S. M., Lee, S., Niculescu-Duvaz, D., Good, V. M., Project, C. G., Jones, C. M., Marshall, C. J., Springer, C. J., Barford, D., & Marais, R. (2004). Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF. Cell. https://doi.org/10.1016/s0092-8674(04)00215-6
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.