The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
p-Terphenyl Derivatives from the Endolichenic Fungus Floricola striata
Abstract
Ten new p-terphenyl derivatives, floricolins A-J (1-10), together with six known compounds (11-16), were isolated from the extract of the endolichenic fungus Floricola striata. Chemical structures of these compounds were elucidated using spectroscopic data (HRESIMS and NMR). Among them, 9 and 10 were enantiomeric mixtures, and their configurations were established by single-crystal X-ray diffraction analysis using Cu Kα radiation. Evaluation of the isolated compounds against Candida albicans revealed that the most active compound, 3 (MIC 8 μg/mL), exerted fungicidal action by destruction of the cell membrane.
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ROS accumulation contributes to cell nuclear dispersion and death.
“Likewise, floricolin C, a p-terphenyl derivative isolated from the fungus Floricola striata, exhibits antifungal activity against C. albicans, with an MIC80 value of 8 μg/mL, and it induces mitochondrial dysfunction by causing ROS accumulation, which further contributes to cell nuclear dispersion and death (68, 69).”
From Recent Progress in Research on Mitochondrion-Targeted Antifungal Drugs: a Review (2023) · cites this paper as [69]
Floricolin C induces mitochondrial dysfunction by causing ROS accumulation.
“Likewise, floricolin C, a p-terphenyl derivative isolated from the fungus Floricola striata, exhibits antifungal activity against C. albicans, with an MIC80 value of 8 μg/mL, and it induces mitochondrial dysfunction by causing ROS accumulation, which further contributes to cell nuclear dispersion and death (68, 69).”
From Recent Progress in Research on Mitochondrion-Targeted Antifungal Drugs: a Review (2023) · cites this paper as [69]
Floricolin C exhibits antifungal activity against C. albicans, with an MIC80 value of 8 μg/mL.
“Likewise, floricolin C, a p-terphenyl derivative isolated from the fungus Floricola striata, exhibits antifungal activity against C. albicans, with an MIC80 value of 8 μg/mL, and it induces mitochondrial dysfunction by causing ROS accumulation, which further contributes to cell nuclear dispersion and death (68, 69).”
From Recent Progress in Research on Mitochondrion-Targeted Antifungal Drugs: a Review (2023) · cites this paper as [69]
Citations
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Li, Y., Chang, W., Zhang, M., Li, X., Jiao, Y., & Lou, H. (2015) · PLOS ONE · doi:10.1371/journal.pone.0128693 · Cited by 79
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Recent Progress in Research on Mitochondrion-Targeted Antifungal Drugs: a Review
Qin, Y., Wang, J., Lv, Q., & Han, B. (2023) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00003-23 · Cited by 38
“…a p -terphenyl derivative isolated from the fungus Floricola striata , exhibits antifungal activity against C. albicans , with an MIC 80 value of 8 m g/mL, and it induces mitochondrial dysfunction by causing ROS accumulation, which further contributes to cell nuclear dispersion and death (68, 69).”
Background
Metadata
- Authors
- Li, W., Gao, W., Zhang, M., Li, Y.-L., Li, L., Li, X.-B., Chang, W.-Q., Zhao, Z.-T., & Lou, H.-X.
- Affiliations
- Shandong University (CN)
- Shandong Normal University (CN)
- Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, China
- Corresponding author
- Zhao, Zun-Tian
- Lou, Hong-Xiang
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-08-24
- Volume
- 79
- Issue
- 9
- Pages
- 2188-2194
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W2512602723
- Cited by
- 48
- References
- 1
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 6 · 2020: 7 · 2019: 8 · 2018: 5 · 2017: 4
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Natural Products (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81273383, 81473107)
- Topics
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Bioactive natural compounds
- Physical Sciences › Chemistry › Organic Chemistry › Bioactive Natural Diterpenoids Research
- Keywords
- p-terphenyl derivatives, endolichenic fungi, fungal natural products, structure elucidation, enantiomeric mixtures, stereochemistry, Candida albicans, antifungal activity, cell membrane damage
- MeSH terms
- Anti-Bacterial Agents, Ascomycota, Candida albicans, Escherichia coli, Microbial Sensitivity Tests, Staphylococcus aureus, Terphenyl Compounds, Molecular Structure, Crystallography, X-Ray
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