Microfluidic Mixing: A General Method for Encapsulating Macromolecules in Lipid Nanoparticle Systems

Leung, Alex K. K., Tam, Yuen Yi C., Chen, Sam, Hafez, Ismail M., Cullis, Pieter R.·2015·The Journal of Physical Chemistry B

Cited by (359)

Items 301–359 of 359

  1. Long Non-coding RNA Involved in the Pathophysiology of Atrial Fibrillation
    Zikan Zhong, Xintao Li, Longzhe Gao, Xiaoyu O. Wu, Yutong Ye, Xiaoyu Zhang, Qingye Zeng, Changzuan Zhou, Xiaofeng Lu, Yong Quek Wei et al. · 2023 · Cardiovascular Drugs and Therapy
  2. Development and optimisation of cationic lipid nanoparticles for mRNA delivery
    Dongnan Yan, Haonan Lu, Apanpreet Kaur, Ruisi Fu, Ning Wang, Jin Hui Teh, Hantao Lou, Eric Ofori Aboagye, Rongjun Chen · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  3. Adverse Epigenetic Effects of Environmental Engineered Nanoparticles as Drug Carriers
    Yingxue Zhang, Eid S. Alshammari, Nouran Yonis, Zhe Yang · 2023 · Wiley eBooks
  4. Nanomedicine in The Treatment of Diabetes: Emerging Nanotherapeutic Strategies of Novel Drug Delivery Systems
    Md Shahidul Islam, Guranda Maisuradze, Quirina Cho Afanwi · 2025 · European Medical Journal
  5. Mechanobiologically Engineered Mimicry of Extracellular Vesicles for Improved Systemic Biodistribution and Anti‐Inflammatory Treatment Efficacy in Rheumatoid Arthritis
    Dahwun Kim, Hwira Baek, Su Yeon Lim, Min Sang Lee, Siyan Lyu, Jihyun Lee, Tun Naw Sut, Marta C. Goncalves, Jeong Yi Kang, Joshua A. Jackman et al. · 2025 · Advanced Healthcare Materials
  6. Helper lipids accelerate the mass transfer of cationic lipid nanoparticles resulting in an efficient gene delivery
    Anurag Sharma, Khushika Khushika, Monika Chaudhary, Pritam Kumar Jana, Nagma Parveen · 2025 · Nanoscale
  7. Advances in lipids design for LNP-mediated DNA and RNA delivery
    Defu Zhi, Ayinigeer Halemaimaiti, Baiyan Dai, Huaiyu Li, Haoran Wang, Ziru Zhang, Jicheng Yu, Shubiao Zhang · 2026 · Advances in Colloid and Interface Science
  8. Direct Counting of mRNA Copies Inside Individual Lipid Nanoparticles Using In Situ Lysis and Labeling
    Sadie Graves, Martin Jasinski, Erik Olsén, Albert Kamanzi, Yao Zhang, Jerry Leung, Michael Venier-Karzis, Amin Safaeesirat, Pieter R. Cullis, Sabrina R. Leslie · 2026 · Analytical Chemistry
  9. Low cost design and fabrication of PDMS microfluidics micromixers for DNA extraction
    Adilah Ayoib, U. Hashim, Subash C. B. Gopinath, M. K. Md Arshad, Norizah Abd Karim, V. Thivina, Noradiba Nordin, R. Yopop · 2017 · IEEE Regional Symposium on Micro and Nanoelectronics
  10. Biocompatible ionic liquid-based nanoparticles for effective skin penetration and intracellular uptake of antisense oligonucleotides
    Kiyohiro Toyofuku, Rie Wakabayashi, Yoshirou Kawaguchi, Noriho Kamiya, Masahiro Goto · 2025 · RSC Pharmaceutics
  11. Enhancement of the vorticity based on side feeding in a microdevice
    João Víctor Melo Amaral, Lucimara Gaziola de la Torre, Sávio S.V. Vianna · 2022 · Microfluidics and Nanofluidics
  12. Drug discovery efforts at George Mason University
    Ali Andalibi, Rémi Veneziano, Mikell A. Paige, Michael D. Buschmann, Amanda N Haymond, Virginia A. Espina, Alessandra Luchini, Lance A. Liotta, Barney Bishop, Monique L. van Hoek · 2023 · SLAS DISCOVERY
  13. ObLiGaRe doxycycline Inducible (ODIn) Cas9 system driving pre-clinical drug discovery, from design to cancer treatment
    Anders Lundin, Michelle J. Porritt, Himjyot Jaiswal, Frank Seeliger, Camilla Johansson, Abdel Wahad Bidar, Lukas Badertscher, Emma Jane Davies, Elizabeth L. Hardaker, Carla P. Martins et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  14. Defining the EM-signature of successful cell-transfection
    Joshua G. Pemberton, Tatyana I. Tenkova, Philip Louis Felgner, Joshua J. Zimmerberg, Tamás Balla, John E. Heuser · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  15. Structural Characterization of mRNA Lipid Nanoparticles in the Presence of Intrinsic Drug-free Lipid Nanoparticles
    Xiaoxia Chen, Yongfeng Ye, Mengrong Li, Taisen Zuo, Zhenhua Xie, Yubin Ke, He Cheng, Liang Hong, Zhuo Liu · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  16. An in vitro nanocarrier-based B cell antigen loading system; tumor growth suppression via transfusion of the antigen-loaded B cells in vivo
    Yoshino Kawaguchi, Taro Shimizu, Haruka Takata, Hidenori Ando, Tatsuhiro Ishida · 2025 · International Journal of Pharmaceutics
  17. Advancements in Cancer Immunotherapy: The Evolution and Future of mRNA and DNA Vaccine Technologies
    Kangchan Choi, Do Hyun Lee, Ji Won Lee, Yong Serk Park · 2025 · Journal of Experimental & Biomedical Sciences/Biomedical Science Letters
  18. Harnessing Nanotechnology for Enhanced CRISPR-Cas Plant Genome Editing
    Harshali Shende, Rajendra Patil · 2025 · Springer eBooks
  19. Comparative Investigation of the Impact of Sodium Citrate Buffers on Lipid Nanoparticles of circRNA or Linear mRNA
    Shurong Zhou, Zitong Wang, You Xu, Tuo Meng, Stephanie Barrett, Guizhi Zhu · 2026 · Molecular Pharmaceutics
  20. Electrostatically‐Stabilized PEG‐Free Lipid Nanoparticles for Systemic Nucleic Acid Delivery
    Namita Nabar, Deeksha Kumaresh, Eduardo Nombera Bueno, Mae L. Pryor, Paula Therese Hammond · 2026 · Advanced Functional Materials
  21. Applications of Spray-Dried Vaccines
    Cordin Arpagaus · 2023 · Springer eBooks
  22. An overview of nanomaterials in drug delivery application
    Ranjana Das, Aishwarya Das, Ishika Singha, Annesha Basu, Chiranjib Bhattacharjee · 2023 · Elsevier eBooks
  23. Polymer Solutions in Microflows: Tracking and Control over Size Distribution
    Artem Bezrukov, Yu. G. Galyametdinov · 2024 · Polymers
  24. pDNA and mRNA vaccines
    Kanwal Gill, Leanne Minall, Aslin Rodríguez Nassif · 2021 · Elsevier eBooks
  25. Lipid nanoparticles for delivery of gene editing components
    Diana D. Kang, Yizhou Dong · 2022 · Elsevier eBooks
  26. Nanoparticle‐Based mRNA Vaccines
    Lakshmi Vineela Nalla, Siva Nageswara Rao Gajula, Vivek P. Chavda · 2024 · Wiley eBooks
  27. Engineering asymmetric nanoscale lipid vesicles for drug delivery
    Chenjing Yang, Julian Menge, Nene Zhvania, Dong Chen, David A. Weitz, Kevin Jahnke · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  28. Investigating alternative delivery systems for self-Amplifying RNA vaccines
    Giulia Anderluzzi · 2019 · STAX
  29. Therapeutic targeting of the leukaemic fusion genes
    Hasan Issa · 2019
  30. Messenger RNA for Prophylaxis
    Nicholas A. C. Jackson · 2022 · RNA technologies
  31. Lipid Nanoparticle-Mediated Delivery of CRISPR-Cas9 for Therapeutic Gene Correction
    Johanna Walther · 2023
  32. Time Resolved Inspection of Ionizable-Lipid Facilitated Lipid Nanoparticle Disintegration and Cargo Release at an Endosomal Membrane Mimic
    Nima Aliakbarinodehi, Simon Niederkofler, Erik Olsén, Yujia Jing, Gustav Emilsson, Mattias Sjöberg, Björn Agnarsson, Lennart Lindfors, Fredrik Höök · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  33. Microfluidics: Current and Future Perspectives
    Justine M. Wagaman, Edward Weaver, Dimitrios A. Lamprou · 2024 · AAPS introductions in the pharmaceutical sciences
  34. Delivery systems for mRNA
    Anya M Hillery · 2024 · Elsevier eBooks
  35. Comparative Analysis of RNAs’ Delivery Systems in diabetic wound healing: Mechanisms, Applications, and Future Prospects
    Yijun Gong, Liangji Guo · 2025 · BIO Web of Conferences
  36. Lipid Nanoparticle Preparations for Diverse Drug Administrations
    Suruihao Liu · 2025 · International Journal of Biology and Life Sciences
  37. Novel approaches to immuno-oncology
    Rui Chen, Fei Su · 2025 · Elsevier eBooks
  38. The effect of guide RNA thermal denaturation on the quality of Cas9 ribonucleoprotein-loaded lipid nanoparticle formulations
    Rina Shimizu, Yuji Kashiwakura, Morisada Hayakawa, Shunsuke Kita, Mina Sato, Masatoshi Maeki, Manabu Tokeshi, Katsumi Maenaka, Tsukasa Ohmori, Yuma Yamada et al. · 2025 · RSC Pharmaceutics
  39. One-step formation of plasmid DNA–loaded lipid–inorganic salt nanoparticles optimized via two-step design of experiments
    Riku Kato, Shintaro Fumoto, Pavan Muttil, Kazuya Okami, Mana Yamashita, H Koyanagi, Hirotaka Miyamoto, Shigeru Kawakami, Koyo Nishida · 2025 · European Journal of Pharmaceutics and Biopharmaceutics
  40. From Hype to Hope: Deconstructing the translational barriers and Charting a new roadmap for Ultrasound-Responsive nanobubbles
    Tianyi Chen, Mingkai Chen, Ruixiao Song, Junli Chen, Yi Wang, Xiaolong Yu · 2025 · International Journal of Pharmaceutics
  41. The Stealth Hazard: Tungsten in Prefilled Syringes Induces mRNA Degradation and Functional Loss in Lipid Nanoparticles Despite Apparent Biophysical Stability
    Changpu Du, Changyun Xiong, Youru Wang, Z.H. Hu, Rui Xing, Wei-Jie Fang · 2026 · Molecular Pharmaceutics
  42. Optimising a mRNA Vaccine platform against HIV-1 : from the in vitro transcription design to envelope protein expression
    Sergio Linares-Fernández · 2021
  43. Drug delivery nanosystems for skeletal muscle treatment in myotonic dystrophy
    Mathieu Repellin · 2022 · theses.fr (ABES)
  44. Viral Infection‐Inspired Autonomous Detection of Fusion‐Competent Viruses for Screening and Environmental Surveillance
    Jae Chul Park, Yidam Song, Hyun‐Woo Choi, Jaeuk Sung, Harin Jin, WonSeok Gwak, Kirim Yoo, Soohwang Lee, Jongeon Park, Jeongmin Kim et al. · 2026 · Advanced Materials
  45. Advancements in nanomedicines for cancer therapy: targeting molecular signaling pathways, activating immune cells, and using photothermal immunomodulation
    Vishal Kumar Deb, Abhishek Mukherjee, Surajit Pathak, Sujay Paul, Asim K. Duttaroy, Suman Adhikari · 2026 · Frontiers in Bioengineering and Biotechnology
  46. Construction of Lipid Nanoparticles Based on Natural Molecules for Safe and Efficient mRNA Delivery
    Taorui Zhong, Haiyang Li, Jiangsheng Xu, Fang Zeng, Shuizhu Wu · 2026 · BioNanoScience
  47. Gene therapy for liver diseases: methods, challenges and opportunities
    Mengyao Yan, Qian Xiang · 2026 · Journal of Nanobiotechnology
  48. Aptamer-Functionalized Liposome Delivery System Based on Multifunctional Microreactor Design
    Jiaqi Guo, Wenjin Chen, Bing Wang, Shanshan Peng, Yannan Wu, Yueyao Lin, Ruiji Lin, Dengyue Chen · 2026 · ACS Applied Materials & Interfaces
  49. 3D‐Printed Milli‐Fluidic Mixing‐Extrusion Platform for Continuous, High‐Throughput LNP Production
    Leekang Jeon, Seeun Kim, Hanjin Seo, Hyun Su Lee, Gi-Su Na, Gi‐Ra Yi, Hyomin Lee · 2026 · Small
  50. Design and development of lipid nanoparticle formulations for brain gene therapy
    Sarah B. Thomson, Alissandra de Moura Gomes, Pardis Kazemian, Daniel Z. Kurek, Jayesh A. Kulkarni, Fariba Saadati, Pamela K. Wagner, Terri L. Petkau, Marco A. Ciufolini, Pieter R. Cullis et al. · 2026 · Molecular Therapy — Nucleic Acids
  51. Towards self-driving laboratories in the biopharmaceutical industry
    Samagra Dvivedi, Nitin Minocha, Shuang Chen, Beata Chertok, Daniel A. Estabrook, Yuchen Fan, Suyong Han, Deepak Jain, Manish S. Kelkar, Alison Lui et al. · 2026 · Nature Synthesis
  52. Lipid Nanoparticles for Gene Therapy: Unresolved Challenges in Manufacturing, Transdermal Delivery, Machine Learning, Endosomal Escape, and the Protein Corona
    Ognjen Milić, Sanela M. Savic, Melanija Zurković, Boban Stanojević, Snezana D. Savic · 2026 · Pharmaceutics
  53. Enhanced nuclear import of DNA-lipid nanoparticles by peptide co-encapsulation
    Alessandra Cavegn, Kevin N. Baumann, David Wang, Megan Anna Stierli, Pascal Detampel, Lorenz Herbster, Lukas Beckert, Larisa E. Kapinos, Philipp M. Späne, Jannes Felsch et al. · 2026 · Journal of Controlled Release
  54. Current Advances in Liver-Targeted Drug Delivery: Synthetic, Biological, and Biomimetic Platforms
    Shynggys D. Sergazy, Роза Б. Сейдахметова, Yernur Zakirov, Askhat Zhilkaidarov, Damirzhan Amirbek, Zarina Shulgau, Kulzhan Berikkhanova, ALEXANDR GULYAEV · 2026 · International Journal of Molecular Sciences
  55. A perspective on targeted LNPs
    Jens B. Simonsen (1953121), Philipp Nicolas Spahn · 2026 · Journal of Controlled Release
  56. Dilution mode acts as a critical process parameter that reprograms lipid nanoparticle assembly and in vivo mRNA delivery
    Siyuan Tang, Lei Huang, Wu Wang, Gang Wu, Zhicong Zhao, Yuan Liu, Qiang Xia, Taihua Yang · 2026 · Journal of Controlled Release
  57. Self-Catalyzed Transesterification Transforms Ionizable Amphiphilic Janus Dendrimers into Multicomponent Vectors and Generates Complex Design Strategies for mRNA Delivery
    Juncheng Lu, Elena N. Atochina‐Vasserman, Dipankar Sahoo, Devendra S. Maurya, Aryaman Tiwary, Mahwish Arshad, Hansika Potti, Saquib Farooq, Nathan A. Ona, Jessica A. Vasserman et al. · 2026 · Journal of the American Chemical Society
  58. Increasing Lipid Nanoparticle mRNA Copy Number Improves Transfection Potency
    Yao Zhang, Jerry Leung, Judy Cheng, Arash Momeni, Albert Kamanzi, Ariadne Tuckmantel Bido, Suiyang Liao, Emma Kang, Colton Strong, Christian J. Kastrup et al. · 2026 · Advanced Materials
  59. Microfluidic channel engineering for mRNA–LNPs: a systematic review of mixing strategies, nanostructures, and biological performance
    Hyejoong Jeong, Cheol Hui Park, Bookun Kim, Junsang Doh, 구희범 · 2026 · Lab on a Chip